Associations between MTHFR and colon cancer
| MTHFR genotype . | Men . | . | . | Women . | . | . | All subjects . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Cases (n) . | Controls (n) . | OR (95% CI)a . | Cases (n) . | Controls (n) . | OR (95% CI) . | Cases (n) . | Controls (n) . | OR (95% CI) . | ||||||
| CC | 372 | 435 | 1.0 | 301 | 392 | 1.0 | 673 | 827 | 1.0 | ||||||
| CT | 378 | 423 | 1.0 (0.9–1.3) | 277 | 359 | 1.0 (0.8–1.3) | 655 | 787 | 1.0 (0.9–1.2) | ||||||
| TT | 74 | 109 | 0.8 (0.6–1.1) | 65 | 98 | 0.9 (0.6–1.2) | 139 | 207 | 0.9 (0.7–1.1) | ||||||
| Distal tumors | |||||||||||||||
| CC | 175 | 435 | 1.0 | 141 | 392 | 1.0 | 316 | 827 | 1.0 | ||||||
| CT | 189 | 423 | 1.1 (0.9–1.5) | 130 | 359 | 1.0 (0.8–1.3) | 329 | 787 | 1.1 (0.9–1.3) | ||||||
| TT | 41 | 109 | 1.0 (0.7–1.5) | 32 | 98 | 0.9 (0.6–1.5) | 73 | 207 | 1.0 (0.7–1.3) | ||||||
| Proximal tumors | |||||||||||||||
| CC | 185 | 435 | 1.0 | 154 | 392 | 1.0 | 339 | 837 | 1.0 | ||||||
| CT | 177 | 423 | 1.0 (0.8–1.3) | 142 | 359 | 1.0 (0.8–1.4) | 319 | 787 | 1.0 (0.8–1.2) | ||||||
| TT | 33 | 109 | 0.7 (0.5–1.1) | 31 | 98 | 0.8 (0.5–1.3) | 64 | 207 | 0.8 (0.6–1.1) | ||||||
| MTHFR genotype . | Men . | . | . | Women . | . | . | All subjects . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Cases (n) . | Controls (n) . | OR (95% CI)a . | Cases (n) . | Controls (n) . | OR (95% CI) . | Cases (n) . | Controls (n) . | OR (95% CI) . | ||||||
| CC | 372 | 435 | 1.0 | 301 | 392 | 1.0 | 673 | 827 | 1.0 | ||||||
| CT | 378 | 423 | 1.0 (0.9–1.3) | 277 | 359 | 1.0 (0.8–1.3) | 655 | 787 | 1.0 (0.9–1.2) | ||||||
| TT | 74 | 109 | 0.8 (0.6–1.1) | 65 | 98 | 0.9 (0.6–1.2) | 139 | 207 | 0.9 (0.7–1.1) | ||||||
| Distal tumors | |||||||||||||||
| CC | 175 | 435 | 1.0 | 141 | 392 | 1.0 | 316 | 827 | 1.0 | ||||||
| CT | 189 | 423 | 1.1 (0.9–1.5) | 130 | 359 | 1.0 (0.8–1.3) | 329 | 787 | 1.1 (0.9–1.3) | ||||||
| TT | 41 | 109 | 1.0 (0.7–1.5) | 32 | 98 | 0.9 (0.6–1.5) | 73 | 207 | 1.0 (0.7–1.3) | ||||||
| Proximal tumors | |||||||||||||||
| CC | 185 | 435 | 1.0 | 154 | 392 | 1.0 | 339 | 837 | 1.0 | ||||||
| CT | 177 | 423 | 1.0 (0.8–1.3) | 142 | 359 | 1.0 (0.8–1.4) | 319 | 787 | 1.0 (0.8–1.2) | ||||||
| TT | 33 | 109 | 0.7 (0.5–1.1) | 31 | 98 | 0.8 (0.5–1.3) | 64 | 207 | 0.8 (0.6–1.1) | ||||||
Adjusted for age, BMI, long-term vigorous physical activity, energy intake, dietary fiber, and usual number of cigarettes smoked.