Relative mutant frequency per type of mutation for spontaneous and PhIP-induced mutations in the DLD-1 cell line
| . | Spontaneous mutant frequencya (×10−6) . | PhlP-induced mutant frequencya (×10−6) . | Fold increaseb . |
|---|---|---|---|
| Total mutant frequencyc | 85 | 210 | 2.5 |
| Base substitutions | 74 | 200 | 2.7 |
| Transitions | 40 | 86 | 2.2 |
| Transversions | 13 | 76 | 5.8 |
| Frameshifts | 11 | 10 | 0.9 |
| Mutations in run of Gsd | 2 | 48 | 24 |
| . | Spontaneous mutant frequencya (×10−6) . | PhlP-induced mutant frequencya (×10−6) . | Fold increaseb . |
|---|---|---|---|
| Total mutant frequencyc | 85 | 210 | 2.5 |
| Base substitutions | 74 | 200 | 2.7 |
| Transitions | 40 | 86 | 2.2 |
| Transversions | 13 | 76 | 5.8 |
| Frameshifts | 11 | 10 | 0.9 |
| Mutations in run of Gsd | 2 | 48 | 24 |
Total mutant frequency multiplied by the incidence of each type of mutation presented in Table 1.
Fold increase induced by PhlP relative to spontaneous mutant frequency.
Total mutant frequencies determined in a parallel induced mutant frequency experiment.
Run of six guanines, base 207 to 212 in exon 3; includes all types of mutations as listed in Table 1.