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Table 1.

Epigenetic Analysis of IGF2 in Serous Epithelial Ovarian Tumors

CharacteristicnAge (Avg)CTCF-1*CTCF-6*,IGF2 DMRLOI§
Borderline 41.4 2/2 0/5 2/3 0/2 
Early stage (I/II) 55.2 6/2 1/8 4/5 0/2 
Advanced stage (III/IV) 64 60.9 37/16 28/29 14/44 5/16 
Normal lymphocytes
 
43
 
N/A
 
3/30
 
2/37
 
2/41
 
N/A
 
Age at diagnosis (y)       
    ≤50 17 44.9 10/5 5/11 7/10 1/3 
    >50 56 64.8 33/13 24/25 11/39 4/15 
    Fisher's exact P
 

 

 
1.00
 
0.27
 
0.21
 
1.00
 
Survival (advanced stage)       
    ≤3 y postdiagnosis 30 59.7 16/6 12/13 7/20 3/7 
    ≥7 y postdiagnosis 24 60.1 15/6 11/11 6/15 2/7 
    Fisher's exact P
 

 

 
1.00
 
1.00
 
1.00
 
1.00
 
IGF2 expression       
    Microarray ≤90 26 57.6 11/9 5/17 10/14 4/3 
    Microarray >90 35 60.7 25/5 18/14 7/24 1/12 
    Fisher's exact P
 

 

 
0.05
 
0.02
 
0.15
 
0.03
 
Epigenetic features       
    Borderline vs malignant   0.58 0.07 0.61 1.00 
    Stage I/II vs III/IV   1.00 0.07 0.24 1.00 
    Malignant vs lymphocytes   <0.0001 <0.0001 0.004 N/A 
CharacteristicnAge (Avg)CTCF-1*CTCF-6*,IGF2 DMRLOI§
Borderline 41.4 2/2 0/5 2/3 0/2 
Early stage (I/II) 55.2 6/2 1/8 4/5 0/2 
Advanced stage (III/IV) 64 60.9 37/16 28/29 14/44 5/16 
Normal lymphocytes
 
43
 
N/A
 
3/30
 
2/37
 
2/41
 
N/A
 
Age at diagnosis (y)       
    ≤50 17 44.9 10/5 5/11 7/10 1/3 
    >50 56 64.8 33/13 24/25 11/39 4/15 
    Fisher's exact P
 

 

 
1.00
 
0.27
 
0.21
 
1.00
 
Survival (advanced stage)       
    ≤3 y postdiagnosis 30 59.7 16/6 12/13 7/20 3/7 
    ≥7 y postdiagnosis 24 60.1 15/6 11/11 6/15 2/7 
    Fisher's exact P
 

 

 
1.00
 
1.00
 
1.00
 
1.00
 
IGF2 expression       
    Microarray ≤90 26 57.6 11/9 5/17 10/14 4/3 
    Microarray >90 35 60.7 25/5 18/14 7/24 1/12 
    Fisher's exact P
 

 

 
0.05
 
0.02
 
0.15
 
0.03
 
Epigenetic features       
    Borderline vs malignant   0.58 0.07 0.61 1.00 
    Stage I/II vs III/IV   1.00 0.07 0.24 1.00 
    Malignant vs lymphocytes   <0.0001 <0.0001 0.004 N/A 

Abbreviation: N/A, not applicable.

*

Number exhibiting hypermethylation/number exhibiting differential methylation.

One sample was not tabulated here because it was hypermethylated at CTCF-6.

Number exhibiting hypomethylation/number exhibiting differential methylation.

§

Number with loss of IGF2 imprinting/number with maintenance of imprinting.

Normal lymphocytes were from individuals without evident malignancy.

Fisher's exact P.

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