Gamma camera ROI analysis of specific 111In-DOTA-ZHER2:342-pep2 tumor uptake in SKOV-3 xenografts
| . | Tumor . | Contralateral thigh . | Tumor-to-contralateral thigh ratio . | |||
|---|---|---|---|---|---|---|
| Time course | ||||||
| 1 h after injection | 271 ± 49 | 29 ± 2 | 9.4 ± 0.9 | |||
| 2 h after injection | 294 ± 59 | 12 ± 4 | 25 ± 6 | |||
| 4 h after injection | 218 ± 45 | 9 ± 3 | 27 ± 17 | |||
| Specificity: block with unlabeled Affibody molecule | ||||||
| Non-blocked | 163 ± 40* | 6.6 ± 0.3 | 25 ± 6† | |||
| Blocked | 32 ± 9* | 8 ± 2 | 4 ± 2† | |||
| Specificity: 17-AAG treatment | ||||||
| Untreated | 126 ± 25‡ | 5 ± 1 | 25 ± 2§ | |||
| Treated | 60 ± 9‡ | 8 ± 2 | 8 ± 3§ | |||
| . | Tumor . | Contralateral thigh . | Tumor-to-contralateral thigh ratio . | |||
|---|---|---|---|---|---|---|
| Time course | ||||||
| 1 h after injection | 271 ± 49 | 29 ± 2 | 9.4 ± 0.9 | |||
| 2 h after injection | 294 ± 59 | 12 ± 4 | 25 ± 6 | |||
| 4 h after injection | 218 ± 45 | 9 ± 3 | 27 ± 17 | |||
| Specificity: block with unlabeled Affibody molecule | ||||||
| Non-blocked | 163 ± 40* | 6.6 ± 0.3 | 25 ± 6† | |||
| Blocked | 32 ± 9* | 8 ± 2 | 4 ± 2† | |||
| Specificity: 17-AAG treatment | ||||||
| Untreated | 126 ± 25‡ | 5 ± 1 | 25 ± 2§ | |||
| Treated | 60 ± 9‡ | 8 ± 2 | 8 ± 3§ | |||
NOTE: Equal ROIs were drawn over the tumor and the contralateral thigh of each animal, and the average counts per pixel from three animals ± SD were calculated.
Significant difference, P = 0.00501.
Significant difference, P = 0.012.
Significant difference, P = 0.013.
Significant difference, P = 0.00152.