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Table 3.

Gamma camera ROI analysis of specific 111In-DOTA-ZHER2:342-pep2 tumor uptake in SKOV-3 xenografts

TumorContralateral thighTumor-to-contralateral thigh ratio
Time course    
    1 h after injection 271 ± 49 29 ± 2 9.4 ± 0.9 
    2 h after injection 294 ± 59 12 ± 4 25 ± 6 
    4 h after injection 218 ± 45 9 ± 3 27 ± 17 
Specificity: block with unlabeled Affibody molecule    
    Non-blocked 163 ± 40* 6.6 ± 0.3 25 ± 6 
    Blocked 32 ± 9* 8 ± 2 4 ± 2 
Specificity: 17-AAG treatment    
    Untreated 126 ± 25 5 ± 1 25 ± 2§ 
    Treated 60 ± 9 8 ± 2 8 ± 3§ 
TumorContralateral thighTumor-to-contralateral thigh ratio
Time course    
    1 h after injection 271 ± 49 29 ± 2 9.4 ± 0.9 
    2 h after injection 294 ± 59 12 ± 4 25 ± 6 
    4 h after injection 218 ± 45 9 ± 3 27 ± 17 
Specificity: block with unlabeled Affibody molecule    
    Non-blocked 163 ± 40* 6.6 ± 0.3 25 ± 6 
    Blocked 32 ± 9* 8 ± 2 4 ± 2 
Specificity: 17-AAG treatment    
    Untreated 126 ± 25 5 ± 1 25 ± 2§ 
    Treated 60 ± 9 8 ± 2 8 ± 3§ 

NOTE: Equal ROIs were drawn over the tumor and the contralateral thigh of each animal, and the average counts per pixel from three animals ± SD were calculated.

*

Significant difference, P = 0.00501.

Significant difference, P = 0.012.

Significant difference, P = 0.013.

§

Significant difference, P = 0.00152.

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