T/O ratios for 111In-DOTA-ZHER2:342-pep2 in mice bearing SKOV-3 xenografts
. | 1 h . | 4 h . | 12 h . | 24 h . | 72 h . |
---|---|---|---|---|---|
Blood | 8 ± 1 | 12 ± 2 | 23 ± 4 | 47 ± 14 | 121 ± 33 |
Heart | 16 ± 4 | 25 ± 4 | 38 ± 5 | 38 ± 12 | 31 ± 11 |
Lung | 7 ± 2 | 16 ± 2 | 22 ± 4 | 24 ± 4 | 17 ± 4 |
Liver | 11 ± 2 | 8 ± 1 | 9 ± 2 | 9 ± 2 | 6 ± 1 |
Spleen | 17 ± 3 | 22 ± 4 | 18 ± 1 | 16 ± 3 | 9 ± 2 |
Pancreas | 28 ± 8 | 52 ± 19 | 46 ± 8 | 40 ± 9 | 29 ± 8 |
Kidney | 0.09 ± 0.01 | 0.05 ± 0.01 | 0.06 ± 0.01 | 0.07 ± 0.02 | 0.06 ± 0.02 |
Stomach | 15 ± 1 | 32 ± 6 | 35 ± 4 | 71 ± 73 | 25 ± 4 |
Salivary gland | 18 ± 3 | 20 ± 7 | 21 ± 4 | 19 ± 3 | 12 ± 3 |
Skin | 11 ± 3 | 19 ± 2 | 14 ± 2 | 15 ± 3 | 9 ± 2 |
Muscle | 36 ± 12 | 53 ± 35 | 68 ± 2 | 65 ± 27 | 48 ± 10 |
Bone | 24 ± 3 | 17 ± 5 | 29 ± 14 | 23 ± 13 | 13 ± 6 |
Brain | 240 ± 124 | 392 ± 120 | 431 ± 101 | 393 ± 41 | 369 ± 117 |
. | 1 h . | 4 h . | 12 h . | 24 h . | 72 h . |
---|---|---|---|---|---|
Blood | 8 ± 1 | 12 ± 2 | 23 ± 4 | 47 ± 14 | 121 ± 33 |
Heart | 16 ± 4 | 25 ± 4 | 38 ± 5 | 38 ± 12 | 31 ± 11 |
Lung | 7 ± 2 | 16 ± 2 | 22 ± 4 | 24 ± 4 | 17 ± 4 |
Liver | 11 ± 2 | 8 ± 1 | 9 ± 2 | 9 ± 2 | 6 ± 1 |
Spleen | 17 ± 3 | 22 ± 4 | 18 ± 1 | 16 ± 3 | 9 ± 2 |
Pancreas | 28 ± 8 | 52 ± 19 | 46 ± 8 | 40 ± 9 | 29 ± 8 |
Kidney | 0.09 ± 0.01 | 0.05 ± 0.01 | 0.06 ± 0.01 | 0.07 ± 0.02 | 0.06 ± 0.02 |
Stomach | 15 ± 1 | 32 ± 6 | 35 ± 4 | 71 ± 73 | 25 ± 4 |
Salivary gland | 18 ± 3 | 20 ± 7 | 21 ± 4 | 19 ± 3 | 12 ± 3 |
Skin | 11 ± 3 | 19 ± 2 | 14 ± 2 | 15 ± 3 | 9 ± 2 |
Muscle | 36 ± 12 | 53 ± 35 | 68 ± 2 | 65 ± 27 | 48 ± 10 |
Bone | 24 ± 3 | 17 ± 5 | 29 ± 14 | 23 ± 13 | 13 ± 6 |
Brain | 240 ± 124 | 392 ± 120 | 431 ± 101 | 393 ± 41 | 369 ± 117 |
NOTE: Each data point presents an average from four animals ± SD.