American Association for Cancer Research

Skip to Main Content

Table 1.

Biodistribution of ¹¹¹In-DOTA-Z_{HER2:342-pep2} and ¹¹¹In-DOTA-Z_taq4:5 in mice bearing SKOV-3 xenografts

	DOTA-Z_{HER2:342-pep2}									DOTA-Z_taq4:5
		1 h	4 h	12 h	24 h	72 h	4 h
Blood	3.0 ± 0.3	1.15 ± 0.05	0.80 ± 0.07	0.32 ± 0.06	0.07 ± 0.01	0.13 ± 0.01
Heart	1.44 ± 0.06	0.55 ± 0.07	0.49 ± 0.06	0.40 ± 0.08	0.28 ± 0.06	0.09 ± 0.02
Lung	3.2 ± 0.3	0.82 ± 0.07	0.86 ± 0.05	0.61 ± 0.08	0.47 ± 0.07	0.17 ± 0.03
Liver	2.0 ± 0.1	1.68 ± 0.05	2.2 ± 0.4	1.7 ± 0.3	1.44 ± 0.06	0.46 ± 0.09
Spleen	1.4 ± 0.2	0.61 ± 0.05	1.1 ± 0.1	1.0 ± 0.3	0.91 ± 0.08	—
Pancreas	0.85 ± 0.08	0.27 ± 0.06	0.41 ± 0.05	0.37 ± 0.04	0.29 ± 0.04	—
Kidney	243 ± 22	256 ± 21	295 ± 24	232 ± 34	138 ± 8	203 ± 36
Stomach	1.6 ± 0.2	0.41 ± 0.04	0.53 ± 0.08	0.4 ± 0.2	0.33 ± 0.06	0.10 ± 0.02
Salivary gland	1.3 ± 0.1	0.7 ± 0.2	0.91 ± 0.07	0.76 ± 0.05	0.71 ± 0.03	0.15 ± 0.03
Thyroid*	0.03 ± 0.02	0.02 ± 0.01	0.02 ± 0.01	0.03 ± 0.01	0.01 ± 0.00	—
Tumor	23 ± 4	13 ± 1 (3 ± 0.7)^†	19 ± 2	15 ± 2	8 ± 2	0.13 ± 0.01
Skin	2.2 ± 0.3	0.76 ± 0.09	1.3 ± 0.2	0.97 ± 0.08	0.9 ± 0.1	0.37 ± 0.09
Muscle	0.7 ± 0.1	0.3 ± 0.3	0.27 ± 0.04	0.25 ± 0.08	0.17 ± 0.02	0.05 ± 0.01
Bone	1.0 ± 0.2	0.7 ± 0.3	0.8 ± 0.3	0.8 ± 0.4	0.7 ± 0.2	0.11 ± 0.01
Brain	0.11 ± 0.04	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01	0.03 ± 0.01	—

	DOTA-Z_{HER2:342-pep2}									DOTA-Z_taq4:5
		1 h	4 h	12 h	24 h	72 h	4 h
Blood	3.0 ± 0.3	1.15 ± 0.05	0.80 ± 0.07	0.32 ± 0.06	0.07 ± 0.01	0.13 ± 0.01
Heart	1.44 ± 0.06	0.55 ± 0.07	0.49 ± 0.06	0.40 ± 0.08	0.28 ± 0.06	0.09 ± 0.02
Lung	3.2 ± 0.3	0.82 ± 0.07	0.86 ± 0.05	0.61 ± 0.08	0.47 ± 0.07	0.17 ± 0.03
Liver	2.0 ± 0.1	1.68 ± 0.05	2.2 ± 0.4	1.7 ± 0.3	1.44 ± 0.06	0.46 ± 0.09
Spleen	1.4 ± 0.2	0.61 ± 0.05	1.1 ± 0.1	1.0 ± 0.3	0.91 ± 0.08	—
Pancreas	0.85 ± 0.08	0.27 ± 0.06	0.41 ± 0.05	0.37 ± 0.04	0.29 ± 0.04	—
Kidney	243 ± 22	256 ± 21	295 ± 24	232 ± 34	138 ± 8	203 ± 36
Stomach	1.6 ± 0.2	0.41 ± 0.04	0.53 ± 0.08	0.4 ± 0.2	0.33 ± 0.06	0.10 ± 0.02
Salivary gland	1.3 ± 0.1	0.7 ± 0.2	0.91 ± 0.07	0.76 ± 0.05	0.71 ± 0.03	0.15 ± 0.03
Thyroid*	0.03 ± 0.02	0.02 ± 0.01	0.02 ± 0.01	0.03 ± 0.01	0.01 ± 0.00	—
Tumor	23 ± 4	13 ± 1 (3 ± 0.7)^†	19 ± 2	15 ± 2	8 ± 2	0.13 ± 0.01
Skin	2.2 ± 0.3	0.76 ± 0.09	1.3 ± 0.2	0.97 ± 0.08	0.9 ± 0.1	0.37 ± 0.09
Muscle	0.7 ± 0.1	0.3 ± 0.3	0.27 ± 0.04	0.25 ± 0.08	0.17 ± 0.02	0.05 ± 0.01
Bone	1.0 ± 0.2	0.7 ± 0.3	0.8 ± 0.3	0.8 ± 0.4	0.7 ± 0.2	0.11 ± 0.01
Brain	0.11 ± 0.04	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01	0.03 ± 0.01	—

NOTE: Each data point presents an average from four animals ± SD and is expressed as %IA/g of organ or tissue.

Data for thyroid presented as percentage of injected radioactivity per organ.

Data in parentheses are given for four animals that were pre-injected with large molar excess of non-labeled Affibody (tumor blocking P < 0.0001).