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Table 1.

Biodistribution of 111In-DOTA-ZHER2:342-pep2 and 111In-DOTA-Ztaq4:5 in mice bearing SKOV-3 xenografts

DOTA-ZHER2:342-pep2
DOTA-Ztaq4:5
1 h4 h12 h24 h72 h4 h
Blood 3.0 ± 0.3 1.15 ± 0.05 0.80 ± 0.07 0.32 ± 0.06 0.07 ± 0.01 0.13 ± 0.01 
Heart 1.44 ± 0.06 0.55 ± 0.07 0.49 ± 0.06 0.40 ± 0.08 0.28 ± 0.06 0.09 ± 0.02 
Lung 3.2 ± 0.3 0.82 ± 0.07 0.86 ± 0.05 0.61 ± 0.08 0.47 ± 0.07 0.17 ± 0.03 
Liver 2.0 ± 0.1 1.68 ± 0.05 2.2 ± 0.4 1.7 ± 0.3 1.44 ± 0.06 0.46 ± 0.09 
Spleen 1.4 ± 0.2 0.61 ± 0.05 1.1 ± 0.1 1.0 ± 0.3 0.91 ± 0.08 — 
Pancreas 0.85 ± 0.08 0.27 ± 0.06 0.41 ± 0.05 0.37 ± 0.04 0.29 ± 0.04 — 
Kidney 243 ± 22 256 ± 21 295 ± 24 232 ± 34 138 ± 8 203 ± 36 
Stomach 1.6 ± 0.2 0.41 ± 0.04 0.53 ± 0.08 0.4 ± 0.2 0.33 ± 0.06 0.10 ± 0.02 
Salivary gland 1.3 ± 0.1 0.7 ± 0.2 0.91 ± 0.07 0.76 ± 0.05 0.71 ± 0.03 0.15 ± 0.03 
Thyroid* 0.03 ± 0.02 0.02 ± 0.01 0.02 ± 0.01 0.03 ± 0.01 0.01 ± 0.00 — 
Tumor 23 ± 4 13 ± 1 (3 ± 0.7) 19 ± 2 15 ± 2 8 ± 2 0.13 ± 0.01 
Skin 2.2 ± 0.3 0.76 ± 0.09 1.3 ± 0.2 0.97 ± 0.08 0.9 ± 0.1 0.37 ± 0.09 
Muscle 0.7 ± 0.1 0.3 ± 0.3 0.27 ± 0.04 0.25 ± 0.08 0.17 ± 0.02 0.05 ± 0.01 
Bone 1.0 ± 0.2 0.7 ± 0.3 0.8 ± 0.3 0.8 ± 0.4 0.7 ± 0.2 0.11 ± 0.01 
Brain 0.11 ± 0.04 0.04 ± 0.01 0.04 ± 0.01 0.04 ± 0.01 0.03 ± 0.01 — 
DOTA-ZHER2:342-pep2
DOTA-Ztaq4:5
1 h4 h12 h24 h72 h4 h
Blood 3.0 ± 0.3 1.15 ± 0.05 0.80 ± 0.07 0.32 ± 0.06 0.07 ± 0.01 0.13 ± 0.01 
Heart 1.44 ± 0.06 0.55 ± 0.07 0.49 ± 0.06 0.40 ± 0.08 0.28 ± 0.06 0.09 ± 0.02 
Lung 3.2 ± 0.3 0.82 ± 0.07 0.86 ± 0.05 0.61 ± 0.08 0.47 ± 0.07 0.17 ± 0.03 
Liver 2.0 ± 0.1 1.68 ± 0.05 2.2 ± 0.4 1.7 ± 0.3 1.44 ± 0.06 0.46 ± 0.09 
Spleen 1.4 ± 0.2 0.61 ± 0.05 1.1 ± 0.1 1.0 ± 0.3 0.91 ± 0.08 — 
Pancreas 0.85 ± 0.08 0.27 ± 0.06 0.41 ± 0.05 0.37 ± 0.04 0.29 ± 0.04 — 
Kidney 243 ± 22 256 ± 21 295 ± 24 232 ± 34 138 ± 8 203 ± 36 
Stomach 1.6 ± 0.2 0.41 ± 0.04 0.53 ± 0.08 0.4 ± 0.2 0.33 ± 0.06 0.10 ± 0.02 
Salivary gland 1.3 ± 0.1 0.7 ± 0.2 0.91 ± 0.07 0.76 ± 0.05 0.71 ± 0.03 0.15 ± 0.03 
Thyroid* 0.03 ± 0.02 0.02 ± 0.01 0.02 ± 0.01 0.03 ± 0.01 0.01 ± 0.00 — 
Tumor 23 ± 4 13 ± 1 (3 ± 0.7) 19 ± 2 15 ± 2 8 ± 2 0.13 ± 0.01 
Skin 2.2 ± 0.3 0.76 ± 0.09 1.3 ± 0.2 0.97 ± 0.08 0.9 ± 0.1 0.37 ± 0.09 
Muscle 0.7 ± 0.1 0.3 ± 0.3 0.27 ± 0.04 0.25 ± 0.08 0.17 ± 0.02 0.05 ± 0.01 
Bone 1.0 ± 0.2 0.7 ± 0.3 0.8 ± 0.3 0.8 ± 0.4 0.7 ± 0.2 0.11 ± 0.01 
Brain 0.11 ± 0.04 0.04 ± 0.01 0.04 ± 0.01 0.04 ± 0.01 0.03 ± 0.01 — 

NOTE: Each data point presents an average from four animals ± SD and is expressed as %IA/g of organ or tissue.

*

Data for thyroid presented as percentage of injected radioactivity per organ.

Data in parentheses are given for four animals that were pre-injected with large molar excess of non-labeled Affibody (tumor blocking P < 0.0001).

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