Expression pattern for β1 integrin, extracellular fibronectin, and laminin-1 in breast cancer
| Factor . | No. patients . | Score, n (%) . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | 0 . | 1 . | 2 . | 3 . | |||
| β1 integrin intensity | 149 | 32 (21.5) | 75 (50.3) | 27 (18.1) | 15 (10.1) | |||
| β1 integrin percentage | 147 | 31 (21.1) | 2 (1.4) | 2 (1.4) | 112 (76.2) | |||
| ECM FN intensity | 134 | 79 (59.8) | 46 (34.8) | 7 (5.3) | 2 (1.5) | |||
| ECM FN pattern | 134 | 79 (59.8) | 8 (6.1) | 14 (10.6) | 33 (25.0) | |||
| ECM LN intensity | 135 | 92 (68.1) | 10 (7.4) | 27 (20.0) | 6 (4.4) | |||
| ECM LN pattern | 135 | 91 (67.4) | 29 (21.5) | 6 (4.4) | 9 (6.7) | |||
| Factor . | No. patients . | Score, n (%) . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | 0 . | 1 . | 2 . | 3 . | |||
| β1 integrin intensity | 149 | 32 (21.5) | 75 (50.3) | 27 (18.1) | 15 (10.1) | |||
| β1 integrin percentage | 147 | 31 (21.1) | 2 (1.4) | 2 (1.4) | 112 (76.2) | |||
| ECM FN intensity | 134 | 79 (59.8) | 46 (34.8) | 7 (5.3) | 2 (1.5) | |||
| ECM FN pattern | 134 | 79 (59.8) | 8 (6.1) | 14 (10.6) | 33 (25.0) | |||
| ECM LN intensity | 135 | 92 (68.1) | 10 (7.4) | 27 (20.0) | 6 (4.4) | |||
| ECM LN pattern | 135 | 91 (67.4) | 29 (21.5) | 6 (4.4) | 9 (6.7) | |||
NOTE: β1 integrin intensity score (based on membranous signal): 0 = none, 1 = light, 2 = moderate, 3 = heavy; β1 integrin percentage score (based on the percentage of tumor cells stained in the sample): 0 = <10%, 1 = 10% to 25%, 2 = 25% to 50%, 3 = >50%; ECM fibronectin intensity score: 0 = none, 1 = light, 2 = moderate, 3 = heavy; ECM fibronectin pattern score (of extracellular staining): negative = 0, focal (<25%) = 1, moderate (25–75%) = 2, diffuse (>75%) = 3; ECM laminin-1 intensity score: 0 = none, 1 = light, 2 = moderate, 3 = heavy; ECM laminin-1 pattern score (of extracellular staining): negative = 0, focal (<25%) = 1, moderate (25–75%) = 2, diffuse (>75%) = 3.
Abbreviations: FN, fibronectin; LN, laminin-1.