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Table 1.

Biodistribution of RCR vector after locoregional virus infusion in immunocompetent CT26 hepatic metastasis model

Copy number of RCR vector in vivo
VectorProdrugNumber of vector copies per 5 × 104 cells
TumorLiverBone marrow
No vector Untreated — — — 
No vector Untreated — — — 
ACE-CD PBS 16,623 — — 
ACE-CD PBS 11,223 — — 
ACE-CD 5FC 8,066 — — 
ACE-CD 5FC 11,174 — — 
Copy number of RCR vector in vivo
VectorProdrugNumber of vector copies per 5 × 104 cells
TumorLiverBone marrow
No vector Untreated — — — 
No vector Untreated — — — 
ACE-CD PBS 16,623 — — 
ACE-CD PBS 11,223 — — 
ACE-CD 5FC 8,066 — — 
ACE-CD 5FC 11,174 — — 

NOTE: Genomic DNA, extracted from liver tumor, normal liver, or bone marrow of ACE-GFP infected mice, was analyzed by quantitative real-time PCR as described in Materials and Methods. As an internal control, each sample was also amplified with mouse β-actin specific primers.

Abbreviation: —, not detectable (detection limit was 20 copies per 5 × 104 cells).

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