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Table 1.

Effect of background/age, Nbs1 genotype, ethylnitrosourea treatment, and Helicobacter status on tumor multiplicity and progression

Mouse typenLifespan (d), mean ± SDIntestinal tumor count, mean ± SDInvasive adenocarcinomas/total tumors (%)*
(A) Phenotype of F1 and controls     
    (BR × B6)F1 72 232 ± 66 19 ± 10 104/185 (56) 
    (SWR × B6)F1 79 370 ± 99 15 ± 10 39/45 (87) 
    B6 97 100 ± 18 122 ± 45 0/74 (0) 
(B) Effect of Nbs1     
    B6 Nbs1+/+ 17 144 ± 48 23 ± 23 6/53 (11) 
    B6 Nbs1+/ΔB 28 175 ± 79 24 ± 14 ND 
    B6 Nbs1ΔB/ ΔB 22 142 ± 42 31 ± 27 10/47 (21) 
    B6 Apc+/+Nbs1ΔB/ΔB 13 ND 0 ± 0 NA 
(C) Effect of ethylnitrosourea treatment     
    (BR × B6)F1, one ethylnitrosourea treatment 202 ± 47 44 ± 22 8/94 (9) 
    (BR × B6)F1, two ethylnitrosourea treatments 180 ± 8 58 ± 20  
    (SWR × B6)F1, one ethylnitrosourea treatment 289 ± 86 19 ± 14 13/35 (38) 
    (SWR × B6)F1, two ethylnitrosourea treatments 190 ± 21 40 ± 17  
(D) Effect of Helicobacter     
    (BR × B6)F1, Helicobacter negative 61 312 ± 82 10 ± 4 9/30 (30) 
    (BR × B6)F1, Helicobacter positive 20 319 ± 100 12 ± 7 13/41 (32) 
    (SWR × B6)F1, Helicobacter negative 58 396 ± 144 13 ± 10 12/38 (32)§ 
    (SWR × B6)F1, Helicobacter positive 12 498 ± 75 8 ± 4 7/29 (24)§ 
Mouse typenLifespan (d), mean ± SDIntestinal tumor count, mean ± SDInvasive adenocarcinomas/total tumors (%)*
(A) Phenotype of F1 and controls     
    (BR × B6)F1 72 232 ± 66 19 ± 10 104/185 (56) 
    (SWR × B6)F1 79 370 ± 99 15 ± 10 39/45 (87) 
    B6 97 100 ± 18 122 ± 45 0/74 (0) 
(B) Effect of Nbs1     
    B6 Nbs1+/+ 17 144 ± 48 23 ± 23 6/53 (11) 
    B6 Nbs1+/ΔB 28 175 ± 79 24 ± 14 ND 
    B6 Nbs1ΔB/ ΔB 22 142 ± 42 31 ± 27 10/47 (21) 
    B6 Apc+/+Nbs1ΔB/ΔB 13 ND 0 ± 0 NA 
(C) Effect of ethylnitrosourea treatment     
    (BR × B6)F1, one ethylnitrosourea treatment 202 ± 47 44 ± 22 8/94 (9) 
    (BR × B6)F1, two ethylnitrosourea treatments 180 ± 8 58 ± 20  
    (SWR × B6)F1, one ethylnitrosourea treatment 289 ± 86 19 ± 14 13/35 (38) 
    (SWR × B6)F1, two ethylnitrosourea treatments 190 ± 21 40 ± 17  
(D) Effect of Helicobacter     
    (BR × B6)F1, Helicobacter negative 61 312 ± 82 10 ± 4 9/30 (30) 
    (BR × B6)F1, Helicobacter positive 20 319 ± 100 12 ± 7 13/41 (32) 
    (SWR × B6)F1, Helicobacter negative 58 396 ± 144 13 ± 10 12/38 (32)§ 
    (SWR × B6)F1, Helicobacter positive 12 498 ± 75 8 ± 4 7/29 (24)§ 

NOTE: All mice are ApcMin/+ unless otherwise specified.

*

Intestinal tumors were isolated from a randomly selected subset of mice of each strain.

Wilcoxon rank-sum P values of the three pair-wise comparisons ≥ 0.3. ND, not done; NA, not applicable.

One or two ethylnitrosourea treatments.

§

One tumor in this set showed metastasis by direct extension to a regional lymph node.

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