Tumor spectrum from Fancd2−/− Trp53+/− and control mice
| . | Control diet . | . | Tempol diet . | . | ||
|---|---|---|---|---|---|---|
| . | Onset (mo.) . | Type of tumor(s) . | Onset (mo.) . | Type of tumor(s) . | ||
| Fancd2−/− Trp53+/− | 6 | Lymphoma | 4 | Lymphoma, Leukemia | ||
| 7 | Lymphoma | 6 | Lymphoma | |||
| 7 | Lymphoma | 6 | Lymphoma | |||
| 8 | Lymphoma | 6 | Lymphoma | |||
| 8 | Adenoma | 12 | Mammary adenocarcinoma | |||
| 9 | Mammary adenocarcinoma | 13 | Ovarian granulosa cell tumor | |||
| 9 | Uterine carcinoma | 13 | Ovarian carcinoma | |||
| 9 | Lymphoma | 14 | Ovarian adenocarcinoma, Stromal tumor | |||
| 10 | Angiosarcoma | 14 | Squamous cell carcinoma | |||
| 10* | 14 | Ovarian carcinoma, Mammary adenocarcinoma, Cystadenoma of the ovary | ||||
| 10 | Ovarian clear cell carcinoma | |||||
| 11 | Mammary adenocarcinoma, Stromal tumor of the ovary | 15 | Ovarian adenocarcinoma | |||
| 15 | Uterine carcinoma | |||||
| 11 | Ovarian adenocarcinoma, Mammary carcinoma | 16 | Soft tissue angiosarcoma | |||
| 16 | Hemangioma of the subcutis | |||||
| 11 | Osteosarcoma | 17 | Mammary carcinoma, Stromal tumor of the ovary | |||
| 11 | Uterine sarcoma | |||||
| 11* | 17 | Acute myeloid lymphoma | ||||
| 12 | Lymphoma | 17 | Mammary adenocarcinoma | |||
| 12 | Ovarian adenocarcinoma | 18 | Angiosarcoma | |||
| 13 | Uterine squamous cell carcinoma, Mammary adenocarcinoma, Acute myeloid lymphoma | |||||
| 14* | ||||||
| 15 | Lymphoma, Leukemia | |||||
| Fancd2+/− Trp53+/− | 13 | Osteosarcoma | 14 | Lymphoma | ||
| 14 | Osteosarcoma | 16 | Plasmacytoma | |||
| 18 | Mammary sarcomatoid carcinoma, Lymphoma | 17 | Hystiocytoma | |||
| 18† | ||||||
| 20 | Lymphoma, | 18 | Malignant fibrous hystiocytoma of the ovary, Mammary carcinoma | |||
| Angiosarcoma | ||||||
| 21 | Leiomyoma of the uterus, Pheochromocytoma | 22 | Malignant fibrous hystiocytoma of the ovary, Osteosarcoma | |||
| 23 | Leukemia, Sarcoma | |||||
| Fancd2+/+ Trp53+/− | 10† | 18 | Lymphoma, Malignant fibrous hystiocytoma of the ovary | |||
| 14 | Lymphoma | |||||
| 15† | 22 | Rhabdomyosarcoma | ||||
| 16† | 24 | Liposarcoma, Malignant fibrous hystiocytoma | ||||
| . | Control diet . | . | Tempol diet . | . | ||
|---|---|---|---|---|---|---|
| . | Onset (mo.) . | Type of tumor(s) . | Onset (mo.) . | Type of tumor(s) . | ||
| Fancd2−/− Trp53+/− | 6 | Lymphoma | 4 | Lymphoma, Leukemia | ||
| 7 | Lymphoma | 6 | Lymphoma | |||
| 7 | Lymphoma | 6 | Lymphoma | |||
| 8 | Lymphoma | 6 | Lymphoma | |||
| 8 | Adenoma | 12 | Mammary adenocarcinoma | |||
| 9 | Mammary adenocarcinoma | 13 | Ovarian granulosa cell tumor | |||
| 9 | Uterine carcinoma | 13 | Ovarian carcinoma | |||
| 9 | Lymphoma | 14 | Ovarian adenocarcinoma, Stromal tumor | |||
| 10 | Angiosarcoma | 14 | Squamous cell carcinoma | |||
| 10* | 14 | Ovarian carcinoma, Mammary adenocarcinoma, Cystadenoma of the ovary | ||||
| 10 | Ovarian clear cell carcinoma | |||||
| 11 | Mammary adenocarcinoma, Stromal tumor of the ovary | 15 | Ovarian adenocarcinoma | |||
| 15 | Uterine carcinoma | |||||
| 11 | Ovarian adenocarcinoma, Mammary carcinoma | 16 | Soft tissue angiosarcoma | |||
| 16 | Hemangioma of the subcutis | |||||
| 11 | Osteosarcoma | 17 | Mammary carcinoma, Stromal tumor of the ovary | |||
| 11 | Uterine sarcoma | |||||
| 11* | 17 | Acute myeloid lymphoma | ||||
| 12 | Lymphoma | 17 | Mammary adenocarcinoma | |||
| 12 | Ovarian adenocarcinoma | 18 | Angiosarcoma | |||
| 13 | Uterine squamous cell carcinoma, Mammary adenocarcinoma, Acute myeloid lymphoma | |||||
| 14* | ||||||
| 15 | Lymphoma, Leukemia | |||||
| Fancd2+/− Trp53+/− | 13 | Osteosarcoma | 14 | Lymphoma | ||
| 14 | Osteosarcoma | 16 | Plasmacytoma | |||
| 18 | Mammary sarcomatoid carcinoma, Lymphoma | 17 | Hystiocytoma | |||
| 18† | ||||||
| 20 | Lymphoma, | 18 | Malignant fibrous hystiocytoma of the ovary, Mammary carcinoma | |||
| Angiosarcoma | ||||||
| 21 | Leiomyoma of the uterus, Pheochromocytoma | 22 | Malignant fibrous hystiocytoma of the ovary, Osteosarcoma | |||
| 23 | Leukemia, Sarcoma | |||||
| Fancd2+/+ Trp53+/− | 10† | 18 | Lymphoma, Malignant fibrous hystiocytoma of the ovary | |||
| 14 | Lymphoma | |||||
| 15† | 22 | Rhabdomyosarcoma | ||||
| 16† | 24 | Liposarcoma, Malignant fibrous hystiocytoma | ||||