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Table 3.

DNA virus and complex retrovirus oncoproteins and cellular protein interactions

VirusViral oncoproteinCellular targets*
SV40 Large T antigen p53, Rb 
 Small t-antigen PP2A 
Polyoma Large T-antigen Rb 
 Middle T-antigen Src, PI3K, PLC-γ, Shc 
 Small t-antigen PP2A 
Adeno E1A Rb 
 E1B-55K p53 
Adeno type 9 E4-ORF1 Dlg1, PATJ, ZO-2, MAGI-1, MUPP1 
HPV E6 p53, Dlg1, Scribble, PATJ, MAGI-1, MUPP1 
 E7 Rb 
HTLV-1 Tax NFκB, p300/CBP, Dlg1, Scribble 
BPV E5 PDGFβ receptor 
EBV LMP1 TRAFs 
VirusViral oncoproteinCellular targets*
SV40 Large T antigen p53, Rb 
 Small t-antigen PP2A 
Polyoma Large T-antigen Rb 
 Middle T-antigen Src, PI3K, PLC-γ, Shc 
 Small t-antigen PP2A 
Adeno E1A Rb 
 E1B-55K p53 
Adeno type 9 E4-ORF1 Dlg1, PATJ, ZO-2, MAGI-1, MUPP1 
HPV E6 p53, Dlg1, Scribble, PATJ, MAGI-1, MUPP1 
 E7 Rb 
HTLV-1 Tax NFκB, p300/CBP, Dlg1, Scribble 
BPV E5 PDGFβ receptor 
EBV LMP1 TRAFs 

NOTE: Adapted from J. Butel (57).

Abbreviations: Adeno, adenovirus; BPV, bovine papillomavirus; PDGF, platelet-derived growth factor; PI3K, phosphatidylinositol-3 kinase; Polyoma, mouse polyomavirus; PLC-γ, phospholipase C-γ; PP2A, protein phosphatase 2A; TRAF, tumor necrosis factor receptor–associated factor.

*

Additional cellular proteins are reported to interact with some of the viral oncoproteins. This list is representative, not exhaustive.

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