DNA virus and complex retrovirus oncoproteins and cellular protein interactions
| Virus . | Viral oncoprotein . | Cellular targets* . |
|---|---|---|
| SV40 | Large T antigen | p53, Rb |
| Small t-antigen | PP2A | |
| Polyoma | Large T-antigen | Rb |
| Middle T-antigen | Src, PI3K, PLC-γ, Shc | |
| Small t-antigen | PP2A | |
| Adeno | E1A | Rb |
| E1B-55K | p53 | |
| Adeno type 9 | E4-ORF1 | Dlg1, PATJ, ZO-2, MAGI-1, MUPP1 |
| HPV | E6 | p53, Dlg1, Scribble, PATJ, MAGI-1, MUPP1 |
| E7 | Rb | |
| HTLV-1 | Tax | NFκB, p300/CBP, Dlg1, Scribble |
| BPV | E5 | PDGFβ receptor |
| EBV | LMP1 | TRAFs |
| Virus . | Viral oncoprotein . | Cellular targets* . |
|---|---|---|
| SV40 | Large T antigen | p53, Rb |
| Small t-antigen | PP2A | |
| Polyoma | Large T-antigen | Rb |
| Middle T-antigen | Src, PI3K, PLC-γ, Shc | |
| Small t-antigen | PP2A | |
| Adeno | E1A | Rb |
| E1B-55K | p53 | |
| Adeno type 9 | E4-ORF1 | Dlg1, PATJ, ZO-2, MAGI-1, MUPP1 |
| HPV | E6 | p53, Dlg1, Scribble, PATJ, MAGI-1, MUPP1 |
| E7 | Rb | |
| HTLV-1 | Tax | NFκB, p300/CBP, Dlg1, Scribble |
| BPV | E5 | PDGFβ receptor |
| EBV | LMP1 | TRAFs |
NOTE: Adapted from J. Butel (57).
Abbreviations: Adeno, adenovirus; BPV, bovine papillomavirus; PDGF, platelet-derived growth factor; PI3K, phosphatidylinositol-3 kinase; Polyoma, mouse polyomavirus; PLC-γ, phospholipase C-γ; PP2A, protein phosphatase 2A; TRAF, tumor necrosis factor receptor–associated factor.
Additional cellular proteins are reported to interact with some of the viral oncoproteins. This list is representative, not exhaustive.