Skip to Main Content
Table 2.

Examples of cellular proto-oncogenes discovered through either gene capture or insertional mutagenesis by a tumorigenic retrovirus and that have been found mutated in some human cancers

General classOncogeneVirus nameProtein product
Growth factor sis Simian sarcoma virus Platelet-derived growth factor 
Receptor protein tyrosine kinase erbB Avian erythroblastosis virus, Rous-associated virus 1 Epidermal growth factor receptor 
 fms McDonough feline sarcoma virus, Friend murine leukemia virus Colony-stimulating factor receptor 
 kit Hardy-Zuckerman-4 feline sarcoma virus Stem cell factor receptor 
Nonreceptor protein tyrosine kinase abl Abelson murine leukemia virus Tyrosine kinase 
 src Rous sarcoma virus Tyrosine kinase 
Serine/threonine protein kinase raf Murine sarcoma virus 3611 Serine/threonine kinase 
 akt AKT8 Murine leukemia virus Serine/threonine kinase 
G protein H-ras Harvey murine sarcoma virus GDP/GTP binding 
 K-ras Kirsten murine sarcoma virus, Friend murine leukemia virus GDP/GTP binding 
Transcription factor erbA Avian erythroblastosis virus Transcription factor (thyroid hormone receptor) 
 ets Avian myeloblastosis virus E26, Moloney murine leukemia virus Transcription factor 
 myc MC29 myelocytoma virus, Rous associated virus 1, Moloney murine leukemia virus Transcription factor 
 rel Reticuloendotheliosis virus Transcription factor (NFκB family) 
General classOncogeneVirus nameProtein product
Growth factor sis Simian sarcoma virus Platelet-derived growth factor 
Receptor protein tyrosine kinase erbB Avian erythroblastosis virus, Rous-associated virus 1 Epidermal growth factor receptor 
 fms McDonough feline sarcoma virus, Friend murine leukemia virus Colony-stimulating factor receptor 
 kit Hardy-Zuckerman-4 feline sarcoma virus Stem cell factor receptor 
Nonreceptor protein tyrosine kinase abl Abelson murine leukemia virus Tyrosine kinase 
 src Rous sarcoma virus Tyrosine kinase 
Serine/threonine protein kinase raf Murine sarcoma virus 3611 Serine/threonine kinase 
 akt AKT8 Murine leukemia virus Serine/threonine kinase 
G protein H-ras Harvey murine sarcoma virus GDP/GTP binding 
 K-ras Kirsten murine sarcoma virus, Friend murine leukemia virus GDP/GTP binding 
Transcription factor erbA Avian erythroblastosis virus Transcription factor (thyroid hormone receptor) 
 ets Avian myeloblastosis virus E26, Moloney murine leukemia virus Transcription factor 
 myc MC29 myelocytoma virus, Rous associated virus 1, Moloney murine leukemia virus Transcription factor 
 rel Reticuloendotheliosis virus Transcription factor (NFκB family) 

NOTE: Adapted from J. Butel (57) and R. Weinberg (113).

Close Modal

or Create an Account

Close Modal
Close Modal