Skip to Main Content
Table 1.

The overall effects of different levels of DER on body weight and mammary carcinogenesis

DER (%)Experiment 1
Experiment 2
Final body weight (g)Cancer incidence (%)Cancer multiplicity (no./rat)Final body weight (g)Total body weight gain (g)
180 ± 3a 96a 2.4 ± 0.3a 143 ± 3a 95 ± 2a 
— — — 113 ± 1b 68 ± 1b 
10 — — — 111 ± 1b 66 ± 1b 
20 150 ± 1b 60b 1.1 ± 0.2b 106 ± 1bc 61 ± 1b 
40 123 ± 1c 23c 0.3 ± 0.083 c 94 ± 1c 48 ± 1c 
DER (%)Experiment 1
Experiment 2
Final body weight (g)Cancer incidence (%)Cancer multiplicity (no./rat)Final body weight (g)Total body weight gain (g)
180 ± 3a 96a 2.4 ± 0.3a 143 ± 3a 95 ± 2a 
— — — 113 ± 1b 68 ± 1b 
10 — — — 111 ± 1b 66 ± 1b 
20 150 ± 1b 60b 1.1 ± 0.2b 106 ± 1bc 61 ± 1b 
40 123 ± 1c 23c 0.3 ± 0.083 c 94 ± 1c 48 ± 1c 

NOTE: Experiment 1 was a mammary carcinogenesis study as described in Materials and Methods. The rats were fed either an unlimited amount of diet (DER 0%) or were restricted to 80% or 60% of ad libitum intake. In experiment 2, rats were not injected with carcinogen. Rats were fed either an unlimited amount of diet or were restricted to 95%, 90%, 80%, and 60% of the ad libitum intake (DER 5%, 10%, 20%, and 40%) as described in Materials and Methods. Values are means ± SE for body weight and cancer multiplicity (n = 30 in experiment 1, n = 8 in experiment 2). Different superscripts (a–c) within the same column are statistically significant among the levels of energy intake (P < 0.05).

Close Modal

or Create an Account

Close Modal
Close Modal