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Table 1.

Characteristics of UV-induced skin tumors in IL-12–deficient mice and their WT counterparts

Tumor characteristicsTreatment group
% Increase in IL-12 KO
WTIL-12 KO
Tumor incidence (%) 75 90 15 
Total no. tumors/group 42 72 42* 
Tumors/tumor bearing mouse 2.7 ± 0.6 3.8 ± 0.6 29 
Tumor volume/tumor (mm312 ± 5 24 ± 4 50* 
Tumor characteristicsTreatment group
% Increase in IL-12 KO
WTIL-12 KO
Tumor incidence (%) 75 90 15 
Total no. tumors/group 42 72 42* 
Tumors/tumor bearing mouse 2.7 ± 0.6 3.8 ± 0.6 29 
Tumor volume/tumor (mm312 ± 5 24 ± 4 50* 

NOTE: Mice were exposed to UVB (180 mJ/cm2) thrice weekly for a total of 35 wks. Tumor data were recorded at the termination of the experiment. n = 20. Control groups of WT and IL-12 KO mice, which were not exposed to UVB, were also maintained. The mice in control groups did not develop tumors during this period.

*

P < 0.001, significant increase versus WT mice.

P < 0.05, Significant increase versus WT mice.

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