Skip to Main Content
Table 1.

PAM analysis of miRNAs differentially expressed between tumors and normals

CV confusion matrix (threshold = 3.23866)
True/predictedCancerNormalClass error rate
Cancer 63 0.112676056 
Normal 14 0.066666667 
Misclassification error = 0.11    
    
miRNAs
 
Cancer score
 
Normal score
 
 
hsa-mir-200c* 0.1152 −0.5454  
hsa-mir-200a* 0.1059 −0.5012  
hsa-mir-199a −0.098 0.4637  
hsa-mir-143 −0.0946 0.4479  
hsa-mir-199b −0.0887 0.4197  
hsa-mir-141* 0.0874 −0.4138  
hsa-mir-145 −0.0734 0.3473  
hsa-mir-147* −0.0679 0.3212  
hsa-mir-133a −0.0671 0.3176  
hsa-mir-101* −0.0616 0.2917  
hsa-mir-214 −0.0607 0.2873  
hsa-mir-100 −0.0535 0.2533  
hsa-mir-140* −0.0523 0.2474  
hsa-mir-126 −0.0501 0.2371  
hsa-mir-224 −0.0485 0.2294  
hsa-mir-9* −0.0481 0.2277  
hsa-mir-105 −0.0461 0.2184  
hsa-mir-99a −0.037 0.1753  
hsa-mir-125a −0.0315 0.1489  
hsa-mir-211* −0.0248 0.1174  
hsa-mir-127* −0.0232 0.11  
hsa-mir-200b* 0.0179 −0.0847  
hsa-mir-125b-1 −0.0177 0.0837  
hsa-let-7c −0.0152 0.0719  
hsa-let-7d* −0.0138 0.0654  
hsa-mir-124a* −0.0121 0.0574  
hsa-mir-374 −0.0119 0.0563  
hsa-let-7a* −0.0113 0.0533  
hsa-mir-134* −0.0014 0.0068  
CV confusion matrix (threshold = 3.23866)
True/predictedCancerNormalClass error rate
Cancer 63 0.112676056 
Normal 14 0.066666667 
Misclassification error = 0.11    
    
miRNAs
 
Cancer score
 
Normal score
 
 
hsa-mir-200c* 0.1152 −0.5454  
hsa-mir-200a* 0.1059 −0.5012  
hsa-mir-199a −0.098 0.4637  
hsa-mir-143 −0.0946 0.4479  
hsa-mir-199b −0.0887 0.4197  
hsa-mir-141* 0.0874 −0.4138  
hsa-mir-145 −0.0734 0.3473  
hsa-mir-147* −0.0679 0.3212  
hsa-mir-133a −0.0671 0.3176  
hsa-mir-101* −0.0616 0.2917  
hsa-mir-214 −0.0607 0.2873  
hsa-mir-100 −0.0535 0.2533  
hsa-mir-140* −0.0523 0.2474  
hsa-mir-126 −0.0501 0.2371  
hsa-mir-224 −0.0485 0.2294  
hsa-mir-9* −0.0481 0.2277  
hsa-mir-105 −0.0461 0.2184  
hsa-mir-99a −0.037 0.1753  
hsa-mir-125a −0.0315 0.1489  
hsa-mir-211* −0.0248 0.1174  
hsa-mir-127* −0.0232 0.11  
hsa-mir-200b* 0.0179 −0.0847  
hsa-mir-125b-1 −0.0177 0.0837  
hsa-let-7c −0.0152 0.0719  
hsa-let-7d* −0.0138 0.0654  
hsa-mir-124a* −0.0121 0.0574  
hsa-mir-374 −0.0119 0.0563  
hsa-let-7a* −0.0113 0.0533  
hsa-mir-134* −0.0014 0.0068  

NOTE: Of the 39 miRNAs found by SAM analysis, 29 miRNAs, 4 up-modulated and 25 down-modulated, were able to classify normal and tumor samples with a classification rate of 89%. The four miRNAs up-modulated were found amplified in the genomic study done by Zhang et al., 2005; among the miRNAs down-modulated, 10 of 25 were found deleted, 4 are discordant and 11 do not show any copy loss or gain in Zhang study.

*

Concordant.

Discordant.

Unchanged in Zhang study.

Close Modal

or Create an Account

Close Modal
Close Modal