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Table 2.

Response of p53 M135 SH-EP transfectants to cytotoxic drugs in clonogenic assays

DrugCell lineID50*Fold resistanceP
Doxorubicin SHEP/CMV 4.420 ± 0.092   
 SHEP/M135 6.202 ± 0.181 1.40 <0.001 
Vincristine SHEP/CMV 0.608 ± 0.011   
 SHEP/M135 0.899 ± 0.031 1.48 <0.001 
VM26 SHEP/CMV 20.328 ± 1.298   
 SHEP/M135 29.438 ± 0.804 1.45 <0.001 
Cisplatin SHEP/CMV 0.315 ± 0.024 μmol/L   
 SHEP/M135 0.801 ± 0.060 μmol/L 2.54 <0.001 
DrugCell lineID50*Fold resistanceP
Doxorubicin SHEP/CMV 4.420 ± 0.092   
 SHEP/M135 6.202 ± 0.181 1.40 <0.001 
Vincristine SHEP/CMV 0.608 ± 0.011   
 SHEP/M135 0.899 ± 0.031 1.48 <0.001 
VM26 SHEP/CMV 20.328 ± 1.298   
 SHEP/M135 29.438 ± 0.804 1.45 <0.001 
Cisplatin SHEP/CMV 0.315 ± 0.024 μmol/L   
 SHEP/M135 0.801 ± 0.060 μmol/L 2.54 <0.001 
*

Calculated from at least three replicate assays.

Fold resistance was determined by dividing the ID50 of the p53 M135–transfected SH-EP cells by that of the control SH-EP/CMV cells.

For a given drug, P values were determined by comparing the ID50 value for the p53 M135–transfected SH-EP cells with the ID50 value of the control SH-EP/CMV cells assayed in the same series of experiments.

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