SAC transgenic mice defer TRAMP tumor initiation and progression
Mouse genotype* . | Mouse age (mo) . | Total no. mice . | % Mice with prostates showing . | . | . | ||
---|---|---|---|---|---|---|---|
. | . | . | Normal . | PIN . | PCa . | ||
SAC+/−/TRAMP−/− | 3 | 6 | 100 | 0 | 0 | ||
GFP+/−/TRAMP+/− | 3 | 6 | 0 | 83.5 | 16.7 | ||
SAC−/−/TRAMP+/− | 3 | 8 | 25 | 62.5 | 12.5 | ||
SAC+/−/TRAMP+/− | 3 | 8 | 50 | 50 | 0 | ||
SAC+/−/TRAMP−/− | 6 | 7 | 100 | 0 | 0 | ||
GFP+/−/TRAMP+/− | 6 | 11 | 0 | 0 | 100 | ||
SAC−/−/TRAMP+/− | 6 | 18 | 0 | 0 | 100 | ||
SAC+/−/TRAMP+/− | 6 | 14 | 28.6 | 50 | 21.4 |
Mouse genotype* . | Mouse age (mo) . | Total no. mice . | % Mice with prostates showing . | . | . | ||
---|---|---|---|---|---|---|---|
. | . | . | Normal . | PIN . | PCa . | ||
SAC+/−/TRAMP−/− | 3 | 6 | 100 | 0 | 0 | ||
GFP+/−/TRAMP+/− | 3 | 6 | 0 | 83.5 | 16.7 | ||
SAC−/−/TRAMP+/− | 3 | 8 | 25 | 62.5 | 12.5 | ||
SAC+/−/TRAMP+/− | 3 | 8 | 50 | 50 | 0 | ||
SAC+/−/TRAMP−/− | 6 | 7 | 100 | 0 | 0 | ||
GFP+/−/TRAMP+/− | 6 | 11 | 0 | 0 | 100 | ||
SAC−/−/TRAMP+/− | 6 | 18 | 0 | 0 | 100 | ||
SAC+/−/TRAMP+/− | 6 | 14 | 28.6 | 50 | 21.4 |
Abbreviations: PIN, prostatic intraepithelial neoplasia; PCa, adenocarcinoma of the prostate.
The SAC+/−/TRAMP−/−, SAC−/−/TRAMP+/−, and SAC+/−/TRAMP+/− littermates resulted from crosses between the SAC+/− and TRAMP+/− transgenic mice.