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Table 2.

SAC transgenic mice defer TRAMP tumor initiation and progression

Mouse genotype*Mouse age (mo)Total no. mice% Mice with prostates showing
NormalPINPCa
SAC+/−/TRAMP−/− 100 
GFP+/−/TRAMP+/− 83.5 16.7 
SAC−/−/TRAMP+/− 25 62.5 12.5 
SAC+/−/TRAMP+/− 50 50 
SAC+/−/TRAMP−/− 100 
GFP+/−/TRAMP+/− 11 100 
SAC−/−/TRAMP+/− 18 100 
SAC+/−/TRAMP+/− 14 28.6 50 21.4 
Mouse genotype*Mouse age (mo)Total no. mice% Mice with prostates showing
NormalPINPCa
SAC+/−/TRAMP−/− 100 
GFP+/−/TRAMP+/− 83.5 16.7 
SAC−/−/TRAMP+/− 25 62.5 12.5 
SAC+/−/TRAMP+/− 50 50 
SAC+/−/TRAMP−/− 100 
GFP+/−/TRAMP+/− 11 100 
SAC−/−/TRAMP+/− 18 100 
SAC+/−/TRAMP+/− 14 28.6 50 21.4 

Abbreviations: PIN, prostatic intraepithelial neoplasia; PCa, adenocarcinoma of the prostate.

*

The SAC+/−/TRAMP−/−, SAC−/−/TRAMP+/−, and SAC+/−/TRAMP+/− littermates resulted from crosses between the SAC+/− and TRAMP+/− transgenic mice.

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