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Table 1.

Biodistribution data for [18F]FBA-A20FMDV2 after i.v. injection into male nu/nu mice (n = 3 per time point) bearing pairs of DX3puroβ6 (αvβ6) and DX3puro (control) xenografts

Tissue% ID/g ± SD
1 h After injection2 h After injection4 h After injection
Tumor (αvβ60.66 ± 0.09* 0.28 ± 0.03 0.06 ± 0.00 
Tumor (control) 0.21 ± 0.07* 0.07 ± 0.02 0.02 ± 0.01 
Blood 0.27 ± 0.08 0.06 ± 0.03 0.03 ± 0.02 
Liver 0.63 ± 0.18 0.12 ± 0.02 0.03 ± 0.01 
Kidney 3.56 ± 1.38 0.55 ± 0.16 0.15 ± 0.09 
Pancreas 0.23 ± 0.12 0.13 ± 0.12 0.02 ± 0.01 
Heart 0.31 ± 0.13 0.07 ± 0.03 0.02 ± 0.01 
Spleen 0.07 ± 0.02 0.05 ± 0.03 0.01 ± 0.00 
Brain 0.02 ± 0.02 0.01 ± 0.01 0.00 ± 0.00 
Stomach 1.33 ± 0.22 0.42 ± 0.08 0.22 ± 0.13 
Bone 0.29 ± 0.11 0.18 ± 0.14 0.03 ± 0.02 
Muscle 0.56 ± 0.21 0.22 ± 0.14 0.08 ± 0.03 
Gall bladder 15.05 ± 17.29 8.67 ± 4.10 1.97 ± 3.17 
Urine 1,081.91 ± 278.51 331.39 ± 143.10 74.07 ± 70.53 
Bladder 8.25 ± 5.44 7.27 ± 4.92 5.14 ± 6.73 
Tissue% ID/g ± SD
1 h After injection2 h After injection4 h After injection
Tumor (αvβ60.66 ± 0.09* 0.28 ± 0.03 0.06 ± 0.00 
Tumor (control) 0.21 ± 0.07* 0.07 ± 0.02 0.02 ± 0.01 
Blood 0.27 ± 0.08 0.06 ± 0.03 0.03 ± 0.02 
Liver 0.63 ± 0.18 0.12 ± 0.02 0.03 ± 0.01 
Kidney 3.56 ± 1.38 0.55 ± 0.16 0.15 ± 0.09 
Pancreas 0.23 ± 0.12 0.13 ± 0.12 0.02 ± 0.01 
Heart 0.31 ± 0.13 0.07 ± 0.03 0.02 ± 0.01 
Spleen 0.07 ± 0.02 0.05 ± 0.03 0.01 ± 0.00 
Brain 0.02 ± 0.02 0.01 ± 0.01 0.00 ± 0.00 
Stomach 1.33 ± 0.22 0.42 ± 0.08 0.22 ± 0.13 
Bone 0.29 ± 0.11 0.18 ± 0.14 0.03 ± 0.02 
Muscle 0.56 ± 0.21 0.22 ± 0.14 0.08 ± 0.03 
Gall bladder 15.05 ± 17.29 8.67 ± 4.10 1.97 ± 3.17 
Urine 1,081.91 ± 278.51 331.39 ± 143.10 74.07 ± 70.53 
Bladder 8.25 ± 5.44 7.27 ± 4.92 5.14 ± 6.73 
*

P = 0.0023.

P = 0.0003.

P = 0.0002.

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