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Table 1.

Biodistribution data for [¹⁸F]FBA-A20FMDV2 after i.v. injection into male nu/nu mice (n = 3 per time point) bearing pairs of DX3puroβ6 (α_vβ₆) and DX3puro (control) xenografts

Tissue	% ID/g ± SD
Tissue		1 h After injection	2 h After injection	4 h After injection
Tumor (α_vβ₆)	0.66 ± 0.09*	0.28 ± 0.03^†	0.06 ± 0.00^‡
Tumor (control)	0.21 ± 0.07*	0.07 ± 0.02^†	0.02 ± 0.01^‡
Blood	0.27 ± 0.08	0.06 ± 0.03	0.03 ± 0.02
Liver	0.63 ± 0.18	0.12 ± 0.02	0.03 ± 0.01
Kidney	3.56 ± 1.38	0.55 ± 0.16	0.15 ± 0.09
Pancreas	0.23 ± 0.12	0.13 ± 0.12	0.02 ± 0.01
Heart	0.31 ± 0.13	0.07 ± 0.03	0.02 ± 0.01
Spleen	0.07 ± 0.02	0.05 ± 0.03	0.01 ± 0.00
Brain	0.02 ± 0.02	0.01 ± 0.01	0.00 ± 0.00
Stomach	1.33 ± 0.22	0.42 ± 0.08	0.22 ± 0.13
Bone	0.29 ± 0.11	0.18 ± 0.14	0.03 ± 0.02
Muscle	0.56 ± 0.21	0.22 ± 0.14	0.08 ± 0.03
Gall bladder	15.05 ± 17.29	8.67 ± 4.10	1.97 ± 3.17
Urine	1,081.91 ± 278.51	331.39 ± 143.10	74.07 ± 70.53
Bladder	8.25 ± 5.44	7.27 ± 4.92	5.14 ± 6.73

Tissue	% ID/g ± SD
Tissue		1 h After injection	2 h After injection	4 h After injection
Tumor (α_vβ₆)	0.66 ± 0.09*	0.28 ± 0.03^†	0.06 ± 0.00^‡
Tumor (control)	0.21 ± 0.07*	0.07 ± 0.02^†	0.02 ± 0.01^‡
Blood	0.27 ± 0.08	0.06 ± 0.03	0.03 ± 0.02
Liver	0.63 ± 0.18	0.12 ± 0.02	0.03 ± 0.01
Kidney	3.56 ± 1.38	0.55 ± 0.16	0.15 ± 0.09
Pancreas	0.23 ± 0.12	0.13 ± 0.12	0.02 ± 0.01
Heart	0.31 ± 0.13	0.07 ± 0.03	0.02 ± 0.01
Spleen	0.07 ± 0.02	0.05 ± 0.03	0.01 ± 0.00
Brain	0.02 ± 0.02	0.01 ± 0.01	0.00 ± 0.00
Stomach	1.33 ± 0.22	0.42 ± 0.08	0.22 ± 0.13
Bone	0.29 ± 0.11	0.18 ± 0.14	0.03 ± 0.02
Muscle	0.56 ± 0.21	0.22 ± 0.14	0.08 ± 0.03
Gall bladder	15.05 ± 17.29	8.67 ± 4.10	1.97 ± 3.17
Urine	1,081.91 ± 278.51	331.39 ± 143.10	74.07 ± 70.53
Bladder	8.25 ± 5.44	7.27 ± 4.92	5.14 ± 6.73

P = 0.0023.

P = 0.0003.

P = 0.0002.