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Table 1.

Putative tumor maintenance genes

A. Maintenance genes sorted by gene ontology biological process
Type A genes induced when Myc is activated and repressed when Myc is deactivatedType B genes repressed upon Myc activation and reexpressed when Myc is deactivated
Angiogenesis Crhr2, Epas1 — 
Apoptosis Accn1, Casp2, Fadd, Foxo3 Dap, Nfkb1, Sgpl1, Siah2 
Cell cycle/proliferation Ak1, Ccng2, Cdc25c, Ect2, Jun, Lzf D17Wsu104e, Pard6a, Siah2 
Cell adhesion Cspg2, Vcam1 — 
Cell growth and/or maintenance Ect2, Foxo3, Jun, Socs3 — 
Cytoskeleton or microtubule Kifc5a, Krt1-18, Mtap6 6720463E02Rik, Map1lc3, Nde1 
Development or organogenesis/morphogenesis Epas1, Fzd9, Jun, Zbtb16 Arpc1a, Bmp1, Dcx, Nfkb1, Siah2, Th 
Endocytosis Dnm, Cubn — 
Glycolysis Eno1, Pklr — 
Glycosylation St6galnac4, St6gal1 Rpn1 
Metabolism Ak1, Ccs, Galm, Gmip, Gsr, Gyk, Mvk, Sms, Uox 2410012M04Rik, Atp2a2, Cryl1, Fh1, Mcfd2, Psap, Sgpl1, Th 
mRNA processing — A1462438, Cpsf3 
Phosphorylation/dephosphorylation Cdc25c, Dyrk1a, Ltk, Matk, Mvk, Pdk4, Ptk2b Ppm1b, Pxk, Slk, Stk16 
Protein biosynthesis or translation 2410005K20Rik, Cubn, Eif4ebp1, Sars2 Eef2, Eif4b, Mrpl4, Mrps18a, Mrps18b, Tars, Wars 
Protein folding Ccs Cct3, Cct4, Dnajb1, Dnajb10, Dnajb11, Tra1 
Proteolysis Adprtl2, Blmh, Casp2, Erf Bmp1, Xpnpep1 
Signaling/signal transduction Crhr2, Ect2, Eif4ebp1, Epas1, Fadd, Fzd9, Gabrg3, Gcgr, Gmip, Ltk, Matk, Olfr16, Pde1b, Racgap1, Rasal1, Socs3, Stmn4 Arfrp1, Arl4, Crcp, Dcx, Nfkb1, Pdzk11, Pxk 
Transcription D1Ertd161e, Epas1, Erf, Fhl2, Jun, Mnt, Myt1, Rpo1-2, Sox4, Tead4, Tieg1, Zfp28 Nfkb1, Rnf14, Xbp1 
Transport Accn1, Atp1b1, Ccs, Clcn1, Gabrg3, Gsr, Kif20a, Slc6a8, Txndc9, Txn12 1300013B2Rik, Aass, Abcc8, Arl4, Atp2a2, Gdi1, Mcfd2, Sec22l1, Sec23b, Sytl4, Txndc7 
Ubiquitin cycle 2700084L22Rik, Usp2 Pxmp3, Rnf14, Siah2 
Other 2010016F14Rik, C1qtnf1, Dbn1, Mpz, Serpina1a, Serpina1d, Txnip Anxa5, Cmas, Gch1, H2-Q7, H2-D1, LOC280487, Nme2 
Not specified 1500010J02Rik, 1500034J01Rik, 1810030O07Rik, 1810044D09Rik, 2410018L13Rik, 2900054D09Rik, 6230416J20Rik, AI464131, AI591476, BC037006, Bub1, C330027C09Rik, C79407, C80638, Cck, Ceacam11, Cep2, Col5a1, Crlf1, Csnk, D10627, D430019H16Rik, D4Ertd196e, D5Ertd363e, D930048N14Rik, Dlk1, Dnajc11, Egln2, Eif4ebp2, Fez1, Gtse1, H1fx, Hrc, Ide, Iqcf4, Itgb1bp1, Jarid1b, Lpin1, Lpp, Midn, Pcdha10, Phlda3, Pspc1, Riok3, Sct, Sez6, Slc35b1, Slc35e4, Ssbp4, Surf2, Tmem5, Wiz, Zdhhc9, Zfp259, Zfp277 0610010K14Rik, 1110008P14Rik, 1110014C03Rik, 1700023O11Rik, 1810010N17Rik, 1810046J19Rik, 2310004K06Rik, 2410022L05Rik, 2610208E05Rik, 2610507B11Rik, 2900010J23Rik, 833439L19Rik, 5730592L21Rik, 6330442E10Rik, Armet, B230114J08Rik, C130052I12Rik, Cdk5rap3, Cenpc1, Commd7, D030028O16Rik, D19Ertd144e, Derl2, Dnajc3, Fut8, Gas5, Gng12, Ik, Mapbpip, Mrpl54, Ndg2, Pik3c3, Pprc1, Pscd3, Rad17, Sec23ip, Tbrg1, Tgtp, Vasp 
B. Ten early target genes implicated in tumor maintenance in pIns-MycERTAM/RIP7-Bcl-xL transgenic mice
 
      
Probeset ID Gene name Gene symbol Ref Seq EBOX* Present in database (a) GO biological process (b) Published role in cancer 
       
96518_at cDNA sequence BC037006 BC037006 XM_109956 Yes No (a) — 
      (b) No 
100636_at Eukaryotic translation initiation factor 4E binding protein 1 Eif4ebp1 NM_007918 Yes No (a) Insulin receptor signaling pathway, negative regulation of protein biosynthesis, negative regulation of translational initiation, regulation of protein biosynthesis, regulation of translation, and regulation of translational initiation 
      (b) Yes (45) 
99844_at Frizzled homologue 9 (Drosophila) Fzd9 XM_284144 Yes No (a) G-protein coupled receptor protein signaling pathway, Wnt receptor signaling pathway, cell surface receptor linked signal transduction, development, and frizzled signaling pathway 
      (b) Yes (46) 
93647_at Gem-interacting protein Gmip NM_198101 Yes Yes (a) Intracellular signaling cascade and metabolism 
      (b) No 
96682_at ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 4 St6galnac4 NM_011373 Yes Yes (a) Protein amino acid glycosylation 
      (b) Yes (44) 
92202_g_at Zinc finger and BTB domain containing 16 Zbtb16 XM_134826 Yes No (a) Skeletal development, negative regulation of cell proliferation, embryonic pattern specification, anterior, posterior pattern formation, embryonic limb morphogenesis, forelimb morphogenesis, positive regulation of apoptosis, regulation of transcription, negative regulation of transcription, and DNA-dependent, male germ-line stem cell division 
      (b) Yes (43) 
160119_at RIKEN cDNA 5730592L21 gene 5730592L21Rik NM_029720 Yes No (a) — 
      (b) No 
93842_at Death-associated protein Dap NM_146057 No No (a) Apoptosis and induction of apoptosis by extracellular signal 
      (b) No 
160769_at Der1-like domain family, member 2 Derl2 NM_033562 No No (a) — 
      (b) Yes (48) 
98944_at SEC23B (Saccharomyces cerevisiae) Sec23b NM_019787 No Yes (a) Endoplasmic reticulum to Golgi transport, intracellular protein transport, protein transport, and transport 
      (b) No 
A. Maintenance genes sorted by gene ontology biological process
Type A genes induced when Myc is activated and repressed when Myc is deactivatedType B genes repressed upon Myc activation and reexpressed when Myc is deactivated
Angiogenesis Crhr2, Epas1 — 
Apoptosis Accn1, Casp2, Fadd, Foxo3 Dap, Nfkb1, Sgpl1, Siah2 
Cell cycle/proliferation Ak1, Ccng2, Cdc25c, Ect2, Jun, Lzf D17Wsu104e, Pard6a, Siah2 
Cell adhesion Cspg2, Vcam1 — 
Cell growth and/or maintenance Ect2, Foxo3, Jun, Socs3 — 
Cytoskeleton or microtubule Kifc5a, Krt1-18, Mtap6 6720463E02Rik, Map1lc3, Nde1 
Development or organogenesis/morphogenesis Epas1, Fzd9, Jun, Zbtb16 Arpc1a, Bmp1, Dcx, Nfkb1, Siah2, Th 
Endocytosis Dnm, Cubn — 
Glycolysis Eno1, Pklr — 
Glycosylation St6galnac4, St6gal1 Rpn1 
Metabolism Ak1, Ccs, Galm, Gmip, Gsr, Gyk, Mvk, Sms, Uox 2410012M04Rik, Atp2a2, Cryl1, Fh1, Mcfd2, Psap, Sgpl1, Th 
mRNA processing — A1462438, Cpsf3 
Phosphorylation/dephosphorylation Cdc25c, Dyrk1a, Ltk, Matk, Mvk, Pdk4, Ptk2b Ppm1b, Pxk, Slk, Stk16 
Protein biosynthesis or translation 2410005K20Rik, Cubn, Eif4ebp1, Sars2 Eef2, Eif4b, Mrpl4, Mrps18a, Mrps18b, Tars, Wars 
Protein folding Ccs Cct3, Cct4, Dnajb1, Dnajb10, Dnajb11, Tra1 
Proteolysis Adprtl2, Blmh, Casp2, Erf Bmp1, Xpnpep1 
Signaling/signal transduction Crhr2, Ect2, Eif4ebp1, Epas1, Fadd, Fzd9, Gabrg3, Gcgr, Gmip, Ltk, Matk, Olfr16, Pde1b, Racgap1, Rasal1, Socs3, Stmn4 Arfrp1, Arl4, Crcp, Dcx, Nfkb1, Pdzk11, Pxk 
Transcription D1Ertd161e, Epas1, Erf, Fhl2, Jun, Mnt, Myt1, Rpo1-2, Sox4, Tead4, Tieg1, Zfp28 Nfkb1, Rnf14, Xbp1 
Transport Accn1, Atp1b1, Ccs, Clcn1, Gabrg3, Gsr, Kif20a, Slc6a8, Txndc9, Txn12 1300013B2Rik, Aass, Abcc8, Arl4, Atp2a2, Gdi1, Mcfd2, Sec22l1, Sec23b, Sytl4, Txndc7 
Ubiquitin cycle 2700084L22Rik, Usp2 Pxmp3, Rnf14, Siah2 
Other 2010016F14Rik, C1qtnf1, Dbn1, Mpz, Serpina1a, Serpina1d, Txnip Anxa5, Cmas, Gch1, H2-Q7, H2-D1, LOC280487, Nme2 
Not specified 1500010J02Rik, 1500034J01Rik, 1810030O07Rik, 1810044D09Rik, 2410018L13Rik, 2900054D09Rik, 6230416J20Rik, AI464131, AI591476, BC037006, Bub1, C330027C09Rik, C79407, C80638, Cck, Ceacam11, Cep2, Col5a1, Crlf1, Csnk, D10627, D430019H16Rik, D4Ertd196e, D5Ertd363e, D930048N14Rik, Dlk1, Dnajc11, Egln2, Eif4ebp2, Fez1, Gtse1, H1fx, Hrc, Ide, Iqcf4, Itgb1bp1, Jarid1b, Lpin1, Lpp, Midn, Pcdha10, Phlda3, Pspc1, Riok3, Sct, Sez6, Slc35b1, Slc35e4, Ssbp4, Surf2, Tmem5, Wiz, Zdhhc9, Zfp259, Zfp277 0610010K14Rik, 1110008P14Rik, 1110014C03Rik, 1700023O11Rik, 1810010N17Rik, 1810046J19Rik, 2310004K06Rik, 2410022L05Rik, 2610208E05Rik, 2610507B11Rik, 2900010J23Rik, 833439L19Rik, 5730592L21Rik, 6330442E10Rik, Armet, B230114J08Rik, C130052I12Rik, Cdk5rap3, Cenpc1, Commd7, D030028O16Rik, D19Ertd144e, Derl2, Dnajc3, Fut8, Gas5, Gng12, Ik, Mapbpip, Mrpl54, Ndg2, Pik3c3, Pprc1, Pscd3, Rad17, Sec23ip, Tbrg1, Tgtp, Vasp 
B. Ten early target genes implicated in tumor maintenance in pIns-MycERTAM/RIP7-Bcl-xL transgenic mice
 
      
Probeset ID Gene name Gene symbol Ref Seq EBOX* Present in database (a) GO biological process (b) Published role in cancer 
       
96518_at cDNA sequence BC037006 BC037006 XM_109956 Yes No (a) — 
      (b) No 
100636_at Eukaryotic translation initiation factor 4E binding protein 1 Eif4ebp1 NM_007918 Yes No (a) Insulin receptor signaling pathway, negative regulation of protein biosynthesis, negative regulation of translational initiation, regulation of protein biosynthesis, regulation of translation, and regulation of translational initiation 
      (b) Yes (45) 
99844_at Frizzled homologue 9 (Drosophila) Fzd9 XM_284144 Yes No (a) G-protein coupled receptor protein signaling pathway, Wnt receptor signaling pathway, cell surface receptor linked signal transduction, development, and frizzled signaling pathway 
      (b) Yes (46) 
93647_at Gem-interacting protein Gmip NM_198101 Yes Yes (a) Intracellular signaling cascade and metabolism 
      (b) No 
96682_at ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 4 St6galnac4 NM_011373 Yes Yes (a) Protein amino acid glycosylation 
      (b) Yes (44) 
92202_g_at Zinc finger and BTB domain containing 16 Zbtb16 XM_134826 Yes No (a) Skeletal development, negative regulation of cell proliferation, embryonic pattern specification, anterior, posterior pattern formation, embryonic limb morphogenesis, forelimb morphogenesis, positive regulation of apoptosis, regulation of transcription, negative regulation of transcription, and DNA-dependent, male germ-line stem cell division 
      (b) Yes (43) 
160119_at RIKEN cDNA 5730592L21 gene 5730592L21Rik NM_029720 Yes No (a) — 
      (b) No 
93842_at Death-associated protein Dap NM_146057 No No (a) Apoptosis and induction of apoptosis by extracellular signal 
      (b) No 
160769_at Der1-like domain family, member 2 Derl2 NM_033562 No No (a) — 
      (b) Yes (48) 
98944_at SEC23B (Saccharomyces cerevisiae) Sec23b NM_019787 No Yes (a) Endoplasmic reticulum to Golgi transport, intracellular protein transport, protein transport, and transport 
      (b) No 
*

MYC:MAX binding site determined by promoter sequence analysis using Matinspector Software (http://www.genomatix.de).

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