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Table 1.

Biodistribution of 177Lu in BALB/c (nu/nu) mice carrying SKOV-3 xenografts with an approximate diameter of 0.5 cm and injected with [177Lu]pertuzumab

Time after injection (d)
0.33135714
Blood 4.50 ± 0.96 3.39 ± 1.31 2.59 ± 0.46 1.86 ± 1.02 1.30 ± 0.43 0.41 ± 0.21 
Heart 1.25 ± 0.21 1.11 ± 0.53 0.72 ± 0.17 0.54 ± 0.26 0.40 ± 0.17 0.13 ± 0.04 
Lungs 1.71 ± 0.43 1.69 ± 0.66 1.22 ± 0.21 1.04 ± 0.45 0.83 ± 0.24 0.38 ± 0.13 
Tumor 6.11 ± 0.64 5.47 ± 2.76 12.87 ± 3.10 13.75 ± 3.88 12.51 ± 1.40 6.67 ± 2.02 
Bladder 0.41 ± 0.13 0.81 ± 0.68 0.45 ± 0.16 0.44 ± 0.16 0.47 ± 0.28 0.42 ± 0.18 
Liver 1.65 ± 0.31 1.29 ± 0.42 1.08 ± 0.37 0.89 ± 0.30 0.74 ± 0.45 0.80 ± 0.06 
Pancreas 0.34 ± 0.11 0.52 ± 0.15 0.31 ± 0.06 0.24 ± 0.11 0.19 ± 0.07 0.07 ± 0.02 
Spleen 1.18 ± 0.28 1.17 ± 0.35 0.87 ± 0.19 0.95 ± 0.28 0.75 ± 0.18 0.69 ± 0.07 
Kidneys 1.81 ± 0.39 1.52 ± 0.51 1.18 ± 0.13 1.04 ± 0.27 0.76 ± 0.28 0.41 ± 0.04 
Stomach 0.43 ± 0.10 0.43 ± 0.20 0.30 ± 0.05 0.23 ± 0.10 0.18 ± 0.04 0.09 ± 0.01 
Small intestine 0.47 ± 0.21 0.43 ± 0.15 0.31 ± 0.07 0.23 ± 0.11 0.18 ± 0.09 0.08 ± 0.02 
Colon 0.39 ± 0.11 0.40 ± 0.16 0.26 ± 0.09 0.19 ± 0.11 0.16 ± 0.07 0.03 ± 0.02 
Feces 0.24 ± 0.06 0.41 ± 0.23 0.22 ± 0.05 0.25 ± 0.13 0.32 ± 0.11 0.14 ± 0.05 
Skin 0.86 ± 0.22 1.09 ± 0.53 0.99 ± 0.24 0.81 ± 0.39 0.58 ± 0.41 0.40 ± 0.07 
Muscle 0.18 ± 0.06 0.25 ± 0.13 0.24 ± 0.04 0.16 ± 0.07 0.12 ± 0.04 0.04 ± 0.01 
Bone 0.13 ± 0.05 0.42 ± 0.12 0.14 ± 0.07 0.12 ± 0.04 0.16 ± 0.06 0.07 ± 0.07 
Thyroid 0.52 ± 0.08 1.46 ± 0.55 0.47 ± 0.30 0.25 ± 0.13 0.26 ± 0.14 0.15 ± 0.04 
Salivary glands 0.64 ± 0.18 0.97 ± 0.36 0.61 ± 0.20 0.94 ± 0.95 0.45 ± 0.14 0.25 ± 0.08 
Brain 0.09 ± 0.01 0.12 ± 0.06 0.06 ± 0.02 0.06 ± 0.03 0.04 ± 0.01 0.02 ± 0.01 
Time after injection (d)
0.33135714
Blood 4.50 ± 0.96 3.39 ± 1.31 2.59 ± 0.46 1.86 ± 1.02 1.30 ± 0.43 0.41 ± 0.21 
Heart 1.25 ± 0.21 1.11 ± 0.53 0.72 ± 0.17 0.54 ± 0.26 0.40 ± 0.17 0.13 ± 0.04 
Lungs 1.71 ± 0.43 1.69 ± 0.66 1.22 ± 0.21 1.04 ± 0.45 0.83 ± 0.24 0.38 ± 0.13 
Tumor 6.11 ± 0.64 5.47 ± 2.76 12.87 ± 3.10 13.75 ± 3.88 12.51 ± 1.40 6.67 ± 2.02 
Bladder 0.41 ± 0.13 0.81 ± 0.68 0.45 ± 0.16 0.44 ± 0.16 0.47 ± 0.28 0.42 ± 0.18 
Liver 1.65 ± 0.31 1.29 ± 0.42 1.08 ± 0.37 0.89 ± 0.30 0.74 ± 0.45 0.80 ± 0.06 
Pancreas 0.34 ± 0.11 0.52 ± 0.15 0.31 ± 0.06 0.24 ± 0.11 0.19 ± 0.07 0.07 ± 0.02 
Spleen 1.18 ± 0.28 1.17 ± 0.35 0.87 ± 0.19 0.95 ± 0.28 0.75 ± 0.18 0.69 ± 0.07 
Kidneys 1.81 ± 0.39 1.52 ± 0.51 1.18 ± 0.13 1.04 ± 0.27 0.76 ± 0.28 0.41 ± 0.04 
Stomach 0.43 ± 0.10 0.43 ± 0.20 0.30 ± 0.05 0.23 ± 0.10 0.18 ± 0.04 0.09 ± 0.01 
Small intestine 0.47 ± 0.21 0.43 ± 0.15 0.31 ± 0.07 0.23 ± 0.11 0.18 ± 0.09 0.08 ± 0.02 
Colon 0.39 ± 0.11 0.40 ± 0.16 0.26 ± 0.09 0.19 ± 0.11 0.16 ± 0.07 0.03 ± 0.02 
Feces 0.24 ± 0.06 0.41 ± 0.23 0.22 ± 0.05 0.25 ± 0.13 0.32 ± 0.11 0.14 ± 0.05 
Skin 0.86 ± 0.22 1.09 ± 0.53 0.99 ± 0.24 0.81 ± 0.39 0.58 ± 0.41 0.40 ± 0.07 
Muscle 0.18 ± 0.06 0.25 ± 0.13 0.24 ± 0.04 0.16 ± 0.07 0.12 ± 0.04 0.04 ± 0.01 
Bone 0.13 ± 0.05 0.42 ± 0.12 0.14 ± 0.07 0.12 ± 0.04 0.16 ± 0.06 0.07 ± 0.07 
Thyroid 0.52 ± 0.08 1.46 ± 0.55 0.47 ± 0.30 0.25 ± 0.13 0.26 ± 0.14 0.15 ± 0.04 
Salivary glands 0.64 ± 0.18 0.97 ± 0.36 0.61 ± 0.20 0.94 ± 0.95 0.45 ± 0.14 0.25 ± 0.08 
Brain 0.09 ± 0.01 0.12 ± 0.06 0.06 ± 0.02 0.06 ± 0.03 0.04 ± 0.01 0.02 ± 0.01 

NOTE: Mice were sacrificed at 8 h, 1, 3, 5, 7, or 14 d after injection, and a panel of organs, including blood drawn from the heart, was collected, weighed, and analyzed for radioactive content. Mean, decay corrected, SUV, and SE from four mice are presented.

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