American Association for Cancer Research

Skip to Main Content

Table 1.

Effect of HMGA1 sense and antisense on transcriptional activity of p53 family members (p21Luc promoter)

	Empty	p53	TAp63α	Tap73α
TPC-1
Empty	1.0 ± 0.0	3.0 ± 0.9	1.3 ± 0.8	3.5 ± 0.7
HMGA1 sense	1.1 ± 0.2	2.8 ± 1.1	1.2 ± 0.5	3.2 ± 0.9
HMGA1 antisense	1.2 ± 0.6	5.0 ± 0.5*	2.0 ± 0.3^†	4.0 ± 0.8
ARO
Empty	1.0 ± 0.0	22.2 ± 2.4	5.4 ± 0.9	8.3 ± 0.2
HMGA1 sense	1.3 ± 0.9	19.9 ± 3.7	6.2 ± 1.4	9.9 ± 1.5
HMGA1 antisense	1.1 ± 0.4	38.7 ± 2.8*	9.7 ± 4.3^†	12.2 ± 2.8
BC-PAP
Empty	1.0 ± 0.0	4.2 ± 2.1	2.5 ± 1.0	4.6 ± 0.9
HMGA1 sense	1.4 ± 0.3	3.8 ± 2.7	2.6 ± 0.8	4.1 ± 1.3
HMGA1 antisense	0.9 ± 0.3	13.6 ± 5.1*	3.0 ± 1.3	5.9 ± 0.8
Saos-2
Empty	1.0 ± 0.0	14.5 ± 2.1	12.2 ± 1.3	13.6 ± 1.9
HMGA1 sense	1.1 ± 0.4	5.5 ± 1.3*	3.9 ± 2.8^†	5.1 ± 1.6*
HMGA1 antisense	0.8 ± 0.8	13.8 ± 4.3	13.8 ± 1.3	13.1 ± 1.5

	Empty	p53	TAp63α	Tap73α
TPC-1
Empty	1.0 ± 0.0	3.0 ± 0.9	1.3 ± 0.8	3.5 ± 0.7
HMGA1 sense	1.1 ± 0.2	2.8 ± 1.1	1.2 ± 0.5	3.2 ± 0.9
HMGA1 antisense	1.2 ± 0.6	5.0 ± 0.5*	2.0 ± 0.3^†	4.0 ± 0.8
ARO
Empty	1.0 ± 0.0	22.2 ± 2.4	5.4 ± 0.9	8.3 ± 0.2
HMGA1 sense	1.3 ± 0.9	19.9 ± 3.7	6.2 ± 1.4	9.9 ± 1.5
HMGA1 antisense	1.1 ± 0.4	38.7 ± 2.8*	9.7 ± 4.3^†	12.2 ± 2.8
BC-PAP
Empty	1.0 ± 0.0	4.2 ± 2.1	2.5 ± 1.0	4.6 ± 0.9
HMGA1 sense	1.4 ± 0.3	3.8 ± 2.7	2.6 ± 0.8	4.1 ± 1.3
HMGA1 antisense	0.9 ± 0.3	13.6 ± 5.1*	3.0 ± 1.3	5.9 ± 0.8
Saos-2
Empty	1.0 ± 0.0	14.5 ± 2.1	12.2 ± 1.3	13.6 ± 1.9
HMGA1 sense	1.1 ± 0.4	5.5 ± 1.3*	3.9 ± 2.8^†	5.1 ± 1.6*
HMGA1 antisense	0.8 ± 0.8	13.8 ± 4.3	13.8 ± 1.3	13.1 ± 1.5

P < 0.01.

P < 0.05.