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Table 2.

Effects of DNMT inhibitors in various assays

Cytotoxicity*Apoptosis inductionGenotoxicityGenomic demethylationTIMP-3 demethylationTIMP-3 reactivationSssI inhibition
5-aza-CR − 
5-aza-CdR − 
zebularine − − − − 
procaine − − − − − − 
EGCG − − − NA 
RG108 − − − − − 
Cytotoxicity*Apoptosis inductionGenotoxicityGenomic demethylationTIMP-3 demethylationTIMP-3 reactivationSssI inhibition
5-aza-CR − 
5-aza-CdR − 
zebularine − − − − 
procaine − − − − − − 
EGCG − − − NA 
RG108 − − − − − 

Abbreviation: NA, not applicable.

*

Cytotoxicity was determined by colony formation assays.

Apoptosis induction was determined by Annexin V staining.

Genotoxicity was determined by micronuclei formation assays.

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