Effects of DNMT inhibitors on the proliferation of various cancer cell lines
| . | TK6 . | Jurkat . | KG-1 . | HCT116 . | Mean IC20 . |
|---|---|---|---|---|---|
| 5-aza-CR | 0.4 | 0.1 | 0.4 | 0.5 | 0.4 |
| 5-aza-CdR | 0.1 | 0.05 | 0.1 | 0.3 | 0.1 |
| zebularine | 20 | 10 | 20 | 5 | 10 |
| procaine | 400 | 500 | 400 | 400 | 400 |
| EGCG | 10 | 20 | 20 | 10 | 10 |
| RG108 | 20 | 40 | 20 | 20 | 20 |
| . | TK6 . | Jurkat . | KG-1 . | HCT116 . | Mean IC20 . |
|---|---|---|---|---|---|
| 5-aza-CR | 0.4 | 0.1 | 0.4 | 0.5 | 0.4 |
| 5-aza-CdR | 0.1 | 0.05 | 0.1 | 0.3 | 0.1 |
| zebularine | 20 | 10 | 20 | 5 | 10 |
| procaine | 400 | 500 | 400 | 400 | 400 |
| EGCG | 10 | 20 | 20 | 10 | 10 |
| RG108 | 20 | 40 | 20 | 20 | 20 |
NOTE: Numbers indicate cell line–specific IC20 concentrations (in μmol/L) that caused a 20% reduction in cell proliferation after 3 days of growth in drug-supplemented medium.