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Table 1.

Effects of DNMT inhibitors on the proliferation of various cancer cell lines

TK6JurkatKG-1HCT116Mean IC20
5-aza-CR 0.4 0.1 0.4 0.5 0.4 
5-aza-CdR 0.1 0.05 0.1 0.3 0.1 
zebularine 20 10 20 10 
procaine 400 500 400 400 400 
EGCG 10 20 20 10 10 
RG108 20 40 20 20 20 
TK6JurkatKG-1HCT116Mean IC20
5-aza-CR 0.4 0.1 0.4 0.5 0.4 
5-aza-CdR 0.1 0.05 0.1 0.3 0.1 
zebularine 20 10 20 10 
procaine 400 500 400 400 400 
EGCG 10 20 20 10 10 
RG108 20 40 20 20 20 

NOTE: Numbers indicate cell line–specific IC20 concentrations (in μmol/L) that caused a 20% reduction in cell proliferation after 3 days of growth in drug-supplemented medium.

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