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Table 1.

Tissue pharmacokinetics of CPT-11 formulations given by CED

Brain
t1/2 (d)AUC (μg d/g)Clearance (g/d)Mean residence time (d)
60 μg free CPT-11 0.3 16.4 3.6 0.4 
60 μg nanoliposomal CPT-11 6.7 417 0.14 9.6 
0.8 mg nanoliposomal CPT-11 10.7 13,723 0.058 15.4 
1.6 mg nanoliposomal CPT-11 19.7 26,823 0.06 28.5 
     
U87 Tumor
 
    
 t1/2 (d) AUC (μg d/g) Clearance (g/d) Mean residence time (d) 
0.8 mg nanoliposomal CPT-11 43.0 40,315 0.02 62.0 
Brain
t1/2 (d)AUC (μg d/g)Clearance (g/d)Mean residence time (d)
60 μg free CPT-11 0.3 16.4 3.6 0.4 
60 μg nanoliposomal CPT-11 6.7 417 0.14 9.6 
0.8 mg nanoliposomal CPT-11 10.7 13,723 0.058 15.4 
1.6 mg nanoliposomal CPT-11 19.7 26,823 0.06 28.5 
     
U87 Tumor
 
    
 t1/2 (d) AUC (μg d/g) Clearance (g/d) Mean residence time (d) 
0.8 mg nanoliposomal CPT-11 43.0 40,315 0.02 62.0 
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