HMGA1 gene silencing by RNA interference suppresses the metastatic potential of pancreatic adenocarcinoma cells in vivo
| . | Control shRNA (n = 10) . | shHMGA1 (n = 10) . |
|---|---|---|
| Median no. metastases (range) | 6 (1–20) | 0* (0–3) |
| Mice with metastases | 100% | 10%* |
| . | Control shRNA (n = 10) . | shHMGA1 (n = 10) . |
|---|---|---|
| Median no. metastases (range) | 6 (1–20) | 0* (0–3) |
| Mice with metastases | 100% | 10%* |
NOTE: At 4 weeks following orthotopic implantation of 1 × 106 MiaPaCa2 cells stably expressing control or shHMGA1 constructs, necropsy was done. Liver metastases were counted and confirmed histologically. HMGA1 silencing significantly inhibited metastasis in this nude mouse model.
P < 0.05 versus control shRNA group.