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Table 1.

HMGA1 gene silencing by RNA interference suppresses the metastatic potential of pancreatic adenocarcinoma cells in vivo

Control shRNA (n = 10)shHMGA1 (n = 10)
Median no. metastases (range) 6 (1–20) 0* (0–3) 
Mice with metastases 100% 10%* 
Control shRNA (n = 10)shHMGA1 (n = 10)
Median no. metastases (range) 6 (1–20) 0* (0–3) 
Mice with metastases 100% 10%* 

NOTE: At 4 weeks following orthotopic implantation of 1 × 106 MiaPaCa2 cells stably expressing control or shHMGA1 constructs, necropsy was done. Liver metastases were counted and confirmed histologically. HMGA1 silencing significantly inhibited metastasis in this nude mouse model.

*

P < 0.05 versus control shRNA group.

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