Penetration of anticancer drugs through MCLs derived from each cell line and through the coated Teflon membrane alone at 6 hours
| Cell line . | Doxorubicin . | 5-Fluorouracil . | Paclitaxel . | Methotrexate . |
|---|---|---|---|---|
| Ea | 12.3 ± 1.0 | 12.1 ± 0.6 | 18.8 ± 2.1 | 5.78 ± 0.02 |
| E11 | 14.1 ± 3.5 | 14.8 ± 3.9 | ||
| Ra | 55.1 ± 3.2 | 32.3 ± 7.1 | 45.4 ± 4.6 | 33.2 ± 3.0 |
| 1R1 | 35.8 ± 4.5 | 46.9 ± 1.9 | ||
| Cell-free | 84.1 ± 5.4 | 80.3 ± 8.5 | 58.4 ± 1.6 | 45.1 ± 8.0 |
| Cell line . | Doxorubicin . | 5-Fluorouracil . | Paclitaxel . | Methotrexate . |
|---|---|---|---|---|
| Ea | 12.3 ± 1.0 | 12.1 ± 0.6 | 18.8 ± 2.1 | 5.78 ± 0.02 |
| E11 | 14.1 ± 3.5 | 14.8 ± 3.9 | ||
| Ra | 55.1 ± 3.2 | 32.3 ± 7.1 | 45.4 ± 4.6 | 33.2 ± 3.0 |
| 1R1 | 35.8 ± 4.5 | 46.9 ± 1.9 | ||
| Cell-free | 84.1 ± 5.4 | 80.3 ± 8.5 | 58.4 ± 1.6 | 45.1 ± 8.0 |
NOTE: Percent drug penetration is obtained from the ratio of the drug concentration in compartment 2 (at 6 hours) to drug concentration at equilibrium ± SD. Data represent results from three to five experiments. Penetration of paclitaxel and methotrexate was not studied in MCLs derived from E11 and 1R1 cell lines.