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Table 2.

Penetration of anticancer drugs through MCLs derived from each cell line and through the coated Teflon membrane alone at 6 hours

Cell lineDoxorubicin5-FluorouracilPaclitaxelMethotrexate
Ea 12.3 ± 1.0 12.1 ± 0.6 18.8 ± 2.1 5.78 ± 0.02 
E11 14.1 ± 3.5 14.8 ± 3.9   
Ra 55.1 ± 3.2 32.3 ± 7.1 45.4 ± 4.6 33.2 ± 3.0 
1R1 35.8 ± 4.5 46.9 ± 1.9   
Cell-free 84.1 ± 5.4 80.3 ± 8.5 58.4 ± 1.6 45.1 ± 8.0 
Cell lineDoxorubicin5-FluorouracilPaclitaxelMethotrexate
Ea 12.3 ± 1.0 12.1 ± 0.6 18.8 ± 2.1 5.78 ± 0.02 
E11 14.1 ± 3.5 14.8 ± 3.9   
Ra 55.1 ± 3.2 32.3 ± 7.1 45.4 ± 4.6 33.2 ± 3.0 
1R1 35.8 ± 4.5 46.9 ± 1.9   
Cell-free 84.1 ± 5.4 80.3 ± 8.5 58.4 ± 1.6 45.1 ± 8.0 

NOTE: Percent drug penetration is obtained from the ratio of the drug concentration in compartment 2 (at 6 hours) to drug concentration at equilibrium ± SD. Data represent results from three to five experiments. Penetration of paclitaxel and methotrexate was not studied in MCLs derived from E11 and 1R1 cell lines.

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