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Table 2.

Breast cancer risks associated with tagging SNPs, genotyped in set 1, in the 10 genes encoding antioxidant enzymes included in this study

Gene and SNPs*MAFOR [95% CI] (heterozygotes vs common homozygotes)OR [95% CI] (rare homozygotes vs common homozygotes)P (2 df)†,‡Ptrend (1 df)‡
SOD1      
    rs202445, a-6366g 0.17 0.96 [0.84-1.09] 1.30 [0.91-1.85] 0.26 0.79 
    rs4998557, g2809a 0.12 0.97 [0.84-1.13] 0.50 [0.26-0.97] 0.10 0.24 
    rs2070424, a7237g 0.07 0.91 [0.76-1.09] 0.44 [0.16-1.26] 0.17 0.13 
SOD2      
    rs1799725, A16V§ (t>c) 0.49 1.07 [0.93-1.25] 1.01 [0.85-1.20] 0.58 0.86 
    rs2842958, c5774t 0.21 0.99 [0.87-1.13] 0.99 [0.74-1.33] 0.99 0.90 
CAT      
    rs1001179, t-330c 0.22 0.91 [0.80-1.03] 1.01 [0.77-1.32] 0.30 0.32 
    rs1049982, c-20t 0.32 1.08 [0.95-1.23] 0.90 [0.73-1.12] 0.18 0.97 
    rs769217, D389D (c>t) 0.22 1.09 [0.96-1.23] 0.95 [0.72-1.24] 0.37 0.53 
    rs511895, g27168a 0.42 0.88 [0.77-1.01] 1.06 [0.89-1.26] 0.06 0.90 
    rs7104301, a33077g 0.26 0.96 [0.84-1.09] 1.02 [0.80-1.24] 0.75 0.71 
GPX1      
    rs3448, a-1040g 0.25 0.98 [0.87-1.11] 1.24 [0.97-1.58] 0.17 0.36 
    rs1050450, P200L∥ (g>a) 0.31 0.93 [0.83-1.05] 0.96 [0.79-1.18] 0.53 0.40 
GPX4      
    rs757229, c-1999g 0.46 1.18 [1.03-1.36] 1.15 [0.97-1.36] 0.06 0.08 
    rs4807542, P12P (g>a) 0.16 1.13 [0.99-1.29] 0.96 [0.68-1.36] 0.18 0.20 
    rs4807543, a2064c 0.05 0.95 [0.78-1.15] 3.12 [0.84-11.53] 0.17 0.95 
    rs713041, t2572c 0.46 1.01 [0.88-1.16] 0.81 [0.68-0.96] 0.01 0.03 
GSR      
    LD1      
        rs1002149, t-515g 0.16 1.08 [0.95-1.24] 0.86 [0.59-1.26] 0.33 0.58 
        rs8190924, g12508a 0.05 1.05 [0.87-1.28] 1.81 [0.53-6.19] 0.56 0.43 
        rs2978663, a19278g 0.37 0.97 [0.85-1.10] 1.05 [0.87-1.27] 0.64 0.83 
    LD2      
        rs4628224, t28414a 0.19 1.03 [0.90-1.17] 0.93 [0.70-1.23] 0.76 0.97 
        rs8191009, c39396t 0.20 1.11 [0.98-1.26] 0.94 [0.69-1.29] 0.23 0.32 
        rs3926402, g43288a 0.39 1.01 [0.89-1.15] 0.94 [0.78-1.12] 0.69 0.62 
        rs2911678, a45359t 0.22 1.09 [0.96-1.23] 0.97 [0.73-1.28] 0.37 0.42 
TXN      
    LD1      
        rs2301241, a-795g 0.41 1.04 [0.91-1.19] 1.04 [0.87-1.24] 0.82 0.61 
        rs4135165, g1153a 0.09 1.06 [0.91-1.24] 0.94 [0.49-1.81] 0.73 0.54 
        rs1410051, a1363g 0.24 1.04 [0.91-1.18] 0.94 [0.73-1.22] 0.74 0.94 
        rs4135168, a1830g 0.26 0.98 [0.86-1.11] 0.83 [0.65-1.06] 0.33 0.23 
        rs4135172, g2316a 0.08 1.05 [0.89-1.23] 0.88 [0.45-1.72] 0.80 0.73 
        rs4135179, t2715c 0.23 0.86 [0.76-0.98] 1.24 [0.96-1.61] 0.01 0.64 
    IB      
        rs4135192, g5126a 0.33 0.89 [0.79-1.01] 0.97 [0.79-1.20] 0.21 0.29 
        rs2418076, g5363a 0.27 1.09 [0.96-1.24] 0.96 [0.76-1.21] 0.30 0.56 
    LD2      
        rs4135208, a9469g 0.33 0.99 [0.87-1.13] 0.96 [0.78-1.18] 0.94 0.75 
        rs4135211, a10141c 0.07 1.13 [0.95-1.34] 0.85 [0.37-1.93] 0.35 0.26 
        rs4135215, t11216c 0.16 1.00 [0.87-1.14] 0.84 [0.59-1.21] 0.64 0.60 
        rs4135221, g11478a 0.13 0.94 [0.82-1.08] 0.94 [0.59-1.51] 0.68 0.40 
        rs4135225, a12024g 0.33 1.00 [0.88-1.14] 1.06 [0.86-1.31] 0.83 0.69 
        rs2776, g12496a 0.50 0.94 [0.81-1.09] 0.92 [0.77-1.09] 0.60 0.34 
TXNRD1      
    rs4964778, g-19040c 0.18 1.02 [0.90-1.16] 0.87 [0.63-1.21] 0.66 0.82 
    rs4964779, g-10243a 0.12 0.95 [0.82-1.11] 1.09 [0.68-1.74] 0.76 0.72 
    rs4564401, g-1876a 0.07 1.10 [0.93-1.30] 0.84 [0.39-1.79] 0.49 0.42 
    rs10861201, t13855g 0.23 1.00 [0.88-1.14] 0.98 [0.76-1.28] 0.99 0.96 
TXN2      
    rs2281082, a4134c 0.19 1.00 [0.88-1.14] 1.06 [0.76-1.47] 0.94 0.83 
    rs8140110, a8249g 0.09 1.04 [0.89-1.22] 1.53 [0.76-3.12] 0.44 0.36 
    rs8139906, g8624c 0.18 1.00 [0.88-1.14] 1.23 [0.87-1.75] 0.51 0.52 
TXNRD2      
    LD1      
        rs740603, a-15851g 0.46 1.01 [0.88-1.16] 0.98 [0.83-1.16] 0.92 0.84 
        rs2020917, a442g 0.28 1.02 [0.90-1.16] 1.15 [0.93-1.43] 0.45 0.27 
        rs4485648, a9921g 0.20 0.86 [0.76-0.98] 1.12 [0.84-1.50] 0.04 0.24 
    LD2      
        rs5748469, A66S (c>a) 0.33 1.10 [0.98-1.25] 1.25 [1.03-1.52] 0.05 0.02 
        rs756661, g23524a 0.47 0.85 [0.74-0.97] 0.86 [0.72-1.01] 0.05 0.04 
        rs732262, g44669a 0.09 1.12 [0.96-1.32] 0.76 [0.41-1.40] 0.22 0.38 
        rs1548357, t50964c 0.27 1.11 [0.98-1.26] 1.28 [1.03-1.59] 0.04 0.01 
    LD3      
        rs2073750, g55969a 0.21 1.05 [0.93-1.19] 1.00 [0.75-1.32] 0.74 0.59 
        rs3788306, a57317g 0.30 1.03 [0.91-1.17] 1.04 [0.85-1.29] 0.86 0.59 
        rs20773752, I370T (a>g) 0.28 0.89 [0.78-1.00] 1.06 [0.84-1.34] 0.10 0.41 
Gene and SNPs*MAFOR [95% CI] (heterozygotes vs common homozygotes)OR [95% CI] (rare homozygotes vs common homozygotes)P (2 df)†,‡Ptrend (1 df)‡
SOD1      
    rs202445, a-6366g 0.17 0.96 [0.84-1.09] 1.30 [0.91-1.85] 0.26 0.79 
    rs4998557, g2809a 0.12 0.97 [0.84-1.13] 0.50 [0.26-0.97] 0.10 0.24 
    rs2070424, a7237g 0.07 0.91 [0.76-1.09] 0.44 [0.16-1.26] 0.17 0.13 
SOD2      
    rs1799725, A16V§ (t>c) 0.49 1.07 [0.93-1.25] 1.01 [0.85-1.20] 0.58 0.86 
    rs2842958, c5774t 0.21 0.99 [0.87-1.13] 0.99 [0.74-1.33] 0.99 0.90 
CAT      
    rs1001179, t-330c 0.22 0.91 [0.80-1.03] 1.01 [0.77-1.32] 0.30 0.32 
    rs1049982, c-20t 0.32 1.08 [0.95-1.23] 0.90 [0.73-1.12] 0.18 0.97 
    rs769217, D389D (c>t) 0.22 1.09 [0.96-1.23] 0.95 [0.72-1.24] 0.37 0.53 
    rs511895, g27168a 0.42 0.88 [0.77-1.01] 1.06 [0.89-1.26] 0.06 0.90 
    rs7104301, a33077g 0.26 0.96 [0.84-1.09] 1.02 [0.80-1.24] 0.75 0.71 
GPX1      
    rs3448, a-1040g 0.25 0.98 [0.87-1.11] 1.24 [0.97-1.58] 0.17 0.36 
    rs1050450, P200L∥ (g>a) 0.31 0.93 [0.83-1.05] 0.96 [0.79-1.18] 0.53 0.40 
GPX4      
    rs757229, c-1999g 0.46 1.18 [1.03-1.36] 1.15 [0.97-1.36] 0.06 0.08 
    rs4807542, P12P (g>a) 0.16 1.13 [0.99-1.29] 0.96 [0.68-1.36] 0.18 0.20 
    rs4807543, a2064c 0.05 0.95 [0.78-1.15] 3.12 [0.84-11.53] 0.17 0.95 
    rs713041, t2572c 0.46 1.01 [0.88-1.16] 0.81 [0.68-0.96] 0.01 0.03 
GSR      
    LD1      
        rs1002149, t-515g 0.16 1.08 [0.95-1.24] 0.86 [0.59-1.26] 0.33 0.58 
        rs8190924, g12508a 0.05 1.05 [0.87-1.28] 1.81 [0.53-6.19] 0.56 0.43 
        rs2978663, a19278g 0.37 0.97 [0.85-1.10] 1.05 [0.87-1.27] 0.64 0.83 
    LD2      
        rs4628224, t28414a 0.19 1.03 [0.90-1.17] 0.93 [0.70-1.23] 0.76 0.97 
        rs8191009, c39396t 0.20 1.11 [0.98-1.26] 0.94 [0.69-1.29] 0.23 0.32 
        rs3926402, g43288a 0.39 1.01 [0.89-1.15] 0.94 [0.78-1.12] 0.69 0.62 
        rs2911678, a45359t 0.22 1.09 [0.96-1.23] 0.97 [0.73-1.28] 0.37 0.42 
TXN      
    LD1      
        rs2301241, a-795g 0.41 1.04 [0.91-1.19] 1.04 [0.87-1.24] 0.82 0.61 
        rs4135165, g1153a 0.09 1.06 [0.91-1.24] 0.94 [0.49-1.81] 0.73 0.54 
        rs1410051, a1363g 0.24 1.04 [0.91-1.18] 0.94 [0.73-1.22] 0.74 0.94 
        rs4135168, a1830g 0.26 0.98 [0.86-1.11] 0.83 [0.65-1.06] 0.33 0.23 
        rs4135172, g2316a 0.08 1.05 [0.89-1.23] 0.88 [0.45-1.72] 0.80 0.73 
        rs4135179, t2715c 0.23 0.86 [0.76-0.98] 1.24 [0.96-1.61] 0.01 0.64 
    IB      
        rs4135192, g5126a 0.33 0.89 [0.79-1.01] 0.97 [0.79-1.20] 0.21 0.29 
        rs2418076, g5363a 0.27 1.09 [0.96-1.24] 0.96 [0.76-1.21] 0.30 0.56 
    LD2      
        rs4135208, a9469g 0.33 0.99 [0.87-1.13] 0.96 [0.78-1.18] 0.94 0.75 
        rs4135211, a10141c 0.07 1.13 [0.95-1.34] 0.85 [0.37-1.93] 0.35 0.26 
        rs4135215, t11216c 0.16 1.00 [0.87-1.14] 0.84 [0.59-1.21] 0.64 0.60 
        rs4135221, g11478a 0.13 0.94 [0.82-1.08] 0.94 [0.59-1.51] 0.68 0.40 
        rs4135225, a12024g 0.33 1.00 [0.88-1.14] 1.06 [0.86-1.31] 0.83 0.69 
        rs2776, g12496a 0.50 0.94 [0.81-1.09] 0.92 [0.77-1.09] 0.60 0.34 
TXNRD1      
    rs4964778, g-19040c 0.18 1.02 [0.90-1.16] 0.87 [0.63-1.21] 0.66 0.82 
    rs4964779, g-10243a 0.12 0.95 [0.82-1.11] 1.09 [0.68-1.74] 0.76 0.72 
    rs4564401, g-1876a 0.07 1.10 [0.93-1.30] 0.84 [0.39-1.79] 0.49 0.42 
    rs10861201, t13855g 0.23 1.00 [0.88-1.14] 0.98 [0.76-1.28] 0.99 0.96 
TXN2      
    rs2281082, a4134c 0.19 1.00 [0.88-1.14] 1.06 [0.76-1.47] 0.94 0.83 
    rs8140110, a8249g 0.09 1.04 [0.89-1.22] 1.53 [0.76-3.12] 0.44 0.36 
    rs8139906, g8624c 0.18 1.00 [0.88-1.14] 1.23 [0.87-1.75] 0.51 0.52 
TXNRD2      
    LD1      
        rs740603, a-15851g 0.46 1.01 [0.88-1.16] 0.98 [0.83-1.16] 0.92 0.84 
        rs2020917, a442g 0.28 1.02 [0.90-1.16] 1.15 [0.93-1.43] 0.45 0.27 
        rs4485648, a9921g 0.20 0.86 [0.76-0.98] 1.12 [0.84-1.50] 0.04 0.24 
    LD2      
        rs5748469, A66S (c>a) 0.33 1.10 [0.98-1.25] 1.25 [1.03-1.52] 0.05 0.02 
        rs756661, g23524a 0.47 0.85 [0.74-0.97] 0.86 [0.72-1.01] 0.05 0.04 
        rs732262, g44669a 0.09 1.12 [0.96-1.32] 0.76 [0.41-1.40] 0.22 0.38 
        rs1548357, t50964c 0.27 1.11 [0.98-1.26] 1.28 [1.03-1.59] 0.04 0.01 
    LD3      
        rs2073750, g55969a 0.21 1.05 [0.93-1.19] 1.00 [0.75-1.32] 0.74 0.59 
        rs3788306, a57317g 0.30 1.03 [0.91-1.17] 1.04 [0.85-1.29] 0.86 0.59 
        rs20773752, I370T (a>g) 0.28 0.89 [0.78-1.00] 1.06 [0.84-1.34] 0.10 0.41 
*

We have given the dbSNP rs number for each SNP, which is the unique identifier and the best standardized naming system; also, the nucleotide position in intronic variants or codon number in coding SNPs is given related to START codon. The common allele appears before the nucleotide position and the rare allele after it.

†

P (2 df): genotype frequencies in cases and controls were compared using a χ2 test with 2 df.

‡

SNPs with Ptrend or P (2 df) ≤ 0.1 (in bold) were chosen for testing in set 2.

§

Previously associated with breast and prostate cancer (24, 29).

∥

Previously associated with lung cancer (25), breast cancer (28), and bladder cancer (31).

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