. | . | Male . | . | Female . | . | |||
---|---|---|---|---|---|---|---|---|

. | . | OPN^{+/+} (n = 7)
. | OPN^{−/−} (n = 5)
. | OPN^{+/+} (n = 7)
. | OPN^{−/−} (n = 4)
. | |||

BrdUrd | Papilloma | ++* | ++ | +++ | +++ | |||

Epidermis | 3.68 ± 1.86^{†} | 3.13 ± 0.67 | 2.95 ± 1.25 | 2.75 ± 2.14 | ||||

TUNEL | Papilloma | 9.06 ± 7.89^{‡} | 28.13 ± 6.71 | 9.81 ± 8.62 | 14.62 ± 5.12 | |||

Epidermis | 0 ± 0^{§} | 0.20 ± 0.20 | 0 ± 0 | 0.25 ± 0.25 |

. | . | Male . | . | Female . | . | |||
---|---|---|---|---|---|---|---|---|

. | . | OPN^{+/+} (n = 7)
. | OPN^{−/−} (n = 5)
. | OPN^{+/+} (n = 7)
. | OPN^{−/−} (n = 4)
. | |||

BrdUrd | Papilloma | ++* | ++ | +++ | +++ | |||

Epidermis | 3.68 ± 1.86^{†} | 3.13 ± 0.67 | 2.95 ± 1.25 | 2.75 ± 2.14 | ||||

TUNEL | Papilloma | 9.06 ± 7.89^{‡} | 28.13 ± 6.71 | 9.81 ± 8.62 | 14.62 ± 5.12 | |||

Epidermis | 0 ± 0^{§} | 0.20 ± 0.20 | 0 ± 0 | 0.25 ± 0.25 |

*

Quantitation of BrdUrd staining in papillomas. The total number of BrdUrd-stained cells from five randomly selected fields at ×40 magnification per papilloma or sample was obtained. The number obtained was then averaged by the number of mice (*n*) to obtain the number of BrdUrd signals per sample, which was then scored as follows: +, <20 cells; ++, between 20 and 50 cells; +++, >50 cells per sample.

†

Quantitation of BrdUrd staining in the epidermis surrounding papillomas. The average number of BrdUrd-positive cells from 10 fields at ×10 magnification per epidermis section or sample was obtained. The number obtained was then averaged by the number of mice (*n*) to obtain the number of positive signals ± SD per sample.

‡

Quantitation of TUNEL-positive cells in papillomas. The total number of positive signals from five randomly selected fields at ×40 magnification per papilloma of similar morphology [i.e., finger, such as projections (see Fig. 4)] was obtained. The number obtained was then averaged by the number of mice (*n*) ± SD as indicated above.

§

Quantitation of TUNEL-positive cells in the epidermis. The average number of TUNEL-positive cells from 10 fields per epidermis section or sample was assessed. The number obtained was then averaged by the number of mice (*n*) ± SD as indicated above.

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