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Table 2.

Expression validation by real-time PCR

Gene name, + Affymetrix ID / + gene symbol (acronyms) / + representative public IDAverage fold change in IDC vs. DCIS from microarray data (±SD)Fold change in IDC vs. DCIS (real-time PCR results)
T796T661T787T808
Biglycan, 213905_x_at / BGN / AA845258 2.63 ± 1.61 6.02 2.93 2.62 4.4 
MADS box transcription enhancer, factor 2 209200_at /MEF2C / AL536517 2.03 ± 1.41 1.69 1.79 2.89 1.38 
Bullous pemphigoid antigen 1, 204455_at / BPAG1 / NM_001723 0.26 ± 2.92 −1.25 −2.07 −3.49 −12.75 
Olfactomedin-like 2B, 213125_at / OLFML2B /AW007573 2.53 ± 1.87 5.61 2.55 1.44 3.43 
Pleckstrin homology domain containing member 1, 209210_s_at / PLEKHC1 / Z24725 2.5 ± 1.54 2.16 2.16 1.83 1.44 
Periostin, 210809_s_at / POSTN / D13665 2.19 ± 1.73 8.89 4.21 1.78 2.29 
Fibroblast activation protein α, 209955_s_at / FAP / U76833 2.96 ± 1.77 8.92 2.78 2.44 n.d. 
*, Large tumor suppressor homologue 2, 223380_s_at / LATS2 / AF207547 2.34 ± 1.37 1.12 1.65 1.25 n.d. 
Ras-induced senescence 1, 213338_at / RIS1 / BF062629 1.8 ± 1.68 3.65 3.31 3.17 n.d. 
Tumor necrosis factor α-induced protein 6, 206026_s_at / TNFAIP6 /NM_007115 2.61 ± 1.78 4.88 4.21 1.65 n.d. 
213790_at / / W46291 2.8 ± 1.90 6.21 2.39 2.54 n.d. 
*, 226997_at / / W74476 2.99 ± 1.59 12 2.92 3.85 n.d. 
Dapper homologue, 1219179_at / DACT1 / NM_016651 2.74 ± 1.86 6.75 2.24 n.d. 8.18 
Gremlin 1 homologue, 218469_at / GREM1 / NM_013372 3.35 ± 1.93 15.44 2.45 n.d. 2.74 
Leucine-rich repeat containing 15, 213909_at / LRRC15 / AU147799 3.61 ± 1.69 100% 5.01 n.d. 1.88 
Squamous cell carcinoma antigen recognized by T cells 2, 218854_at / SART2 / NM_fs013352 2.26 ± 1.51 3.61 1.68 n.d. 1.33 
Gene name, + Affymetrix ID / + gene symbol (acronyms) / + representative public IDAverage fold change in IDC vs. DCIS from microarray data (±SD)Fold change in IDC vs. DCIS (real-time PCR results)
T796T661T787T808
Biglycan, 213905_x_at / BGN / AA845258 2.63 ± 1.61 6.02 2.93 2.62 4.4 
MADS box transcription enhancer, factor 2 209200_at /MEF2C / AL536517 2.03 ± 1.41 1.69 1.79 2.89 1.38 
Bullous pemphigoid antigen 1, 204455_at / BPAG1 / NM_001723 0.26 ± 2.92 −1.25 −2.07 −3.49 −12.75 
Olfactomedin-like 2B, 213125_at / OLFML2B /AW007573 2.53 ± 1.87 5.61 2.55 1.44 3.43 
Pleckstrin homology domain containing member 1, 209210_s_at / PLEKHC1 / Z24725 2.5 ± 1.54 2.16 2.16 1.83 1.44 
Periostin, 210809_s_at / POSTN / D13665 2.19 ± 1.73 8.89 4.21 1.78 2.29 
Fibroblast activation protein α, 209955_s_at / FAP / U76833 2.96 ± 1.77 8.92 2.78 2.44 n.d. 
*, Large tumor suppressor homologue 2, 223380_s_at / LATS2 / AF207547 2.34 ± 1.37 1.12 1.65 1.25 n.d. 
Ras-induced senescence 1, 213338_at / RIS1 / BF062629 1.8 ± 1.68 3.65 3.31 3.17 n.d. 
Tumor necrosis factor α-induced protein 6, 206026_s_at / TNFAIP6 /NM_007115 2.61 ± 1.78 4.88 4.21 1.65 n.d. 
213790_at / / W46291 2.8 ± 1.90 6.21 2.39 2.54 n.d. 
*, 226997_at / / W74476 2.99 ± 1.59 12 2.92 3.85 n.d. 
Dapper homologue, 1219179_at / DACT1 / NM_016651 2.74 ± 1.86 6.75 2.24 n.d. 8.18 
Gremlin 1 homologue, 218469_at / GREM1 / NM_013372 3.35 ± 1.93 15.44 2.45 n.d. 2.74 
Leucine-rich repeat containing 15, 213909_at / LRRC15 / AU147799 3.61 ± 1.69 100% 5.01 n.d. 1.88 
Squamous cell carcinoma antigen recognized by T cells 2, 218854_at / SART2 / NM_fs013352 2.26 ± 1.51 3.61 1.68 n.d. 1.33 

Abbreviation: n.d., “not determined.”

*

Probe set only on HG U133 Plus 2.0 array.

No gene symbol.

No expression in DCIS detected.

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