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Table 3.

Ratios of formation of metabolites in estrogen hydroxylation catalyzed by human CYP1A1 variants

2-OH/4-OH
2-OH/15α-OH
2-OH/6α-OH
E2E1E2E1E2E1
CYP1A1.1 31.5 8.3 1.4 2.4 1.4 16.5 
CYP1A1.2 59.8 10.2 3.3 8.1 6.0 50.0 
CYP1A1.4 15.5 5.8 0.7 1.2 0.6 11.5 
2-OH/4-OH
2-OH/15α-OH
2-OH/6α-OH
E2E1E2E1E2E1
CYP1A1.1 31.5 8.3 1.4 2.4 1.4 16.5 
CYP1A1.2 59.8 10.2 3.3 8.1 6.0 50.0 
CYP1A1.4 15.5 5.8 0.7 1.2 0.6 11.5 

NOTE: Ratios were calculated based on catalytic efficiencies Vmax/Km. For conditions of experiments and determination, see legend of Table 1.

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