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Table 3.

Relative risks and 95% CI for prostate cancer according to MnSOD genotype and quartiles of individual plasma antioxidant levels

Quartile of prediagnostic plasma antioxidant level*
1234Pinteraction
All prostate cancer      
    Selenium (511 cases and 423 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.57 0.60 0.67 0.05 
        MnSOD AA 1.49 0.80 0.59 0.47 (0.26-0.85)  
    Lycopene (541 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.90 0.92 0.80 0.35 
        MnSOD AA 1.49 0.78 1.08 0.84 (0.51-1.38)  
    α-Tocopherol (541 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 1.16 1.17 1.14 0.13 
        MnSOD AA 1.78 (1.01-3.12) 1.01 1.21 1.12 (0.67-1.88)  
Aggressive prostate cancer      
    Selenium (251 cases and 423 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.71 0.64 0.74 0.01 
        MnSOD AA 1.89 (1.01-3.56) 1.17 0.59 0.35 (0.15-0.82)  
    Lycopene (261 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.78 0.94 0.70 0.23 
        MnSOD AA 1.73 0.69 0.72 0.79 (0.43-1.48)  
    α-Tocopherol (261 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 1.31 1.01 0.89 0.03 
        MnSOD AA 1.97 (1.02-3.79) 1.20 1.01 0.72 (0.35-1.48)  
Quartile of prediagnostic plasma antioxidant level*
1234Pinteraction
All prostate cancer      
    Selenium (511 cases and 423 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.57 0.60 0.67 0.05 
        MnSOD AA 1.49 0.80 0.59 0.47 (0.26-0.85)  
    Lycopene (541 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.90 0.92 0.80 0.35 
        MnSOD AA 1.49 0.78 1.08 0.84 (0.51-1.38)  
    α-Tocopherol (541 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 1.16 1.17 1.14 0.13 
        MnSOD AA 1.78 (1.01-3.12) 1.01 1.21 1.12 (0.67-1.88)  
Aggressive prostate cancer      
    Selenium (251 cases and 423 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.71 0.64 0.74 0.01 
        MnSOD AA 1.89 (1.01-3.56) 1.17 0.59 0.35 (0.15-0.82)  
    Lycopene (261 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 0.78 0.94 0.70 0.23 
        MnSOD AA 1.73 0.69 0.72 0.79 (0.43-1.48)  
    α-Tocopherol (261 cases and 642 controls)      
        MnSOD VV and VA 1.00 (Reference) 1.31 1.01 0.89 0.03 
        MnSOD AA 1.97 (1.02-3.79) 1.20 1.01 0.72 (0.35-1.48)  

NOTE: RR and 95% CI were calculated using unconditional logistic regression, adjusted for age at baseline, smoking status, and duration of follow-up.

*

Based on each antioxidant, men were categorized into quartiles based on the quartile cutoff points among control subjects (batch-specific quartile cutoff points for all antioxidants except selenium).

RR (95% CI).

Aggressive prostate cancer, stage C or D, high-grade tumor (Gleason score 7-10), or prostate cancer deaths during the follow-up.

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