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Table 2.

Tributyrin-induced gene expression and the effect of Bay11-7082 and TMB-8

GeneTributyrin treated
Untreated
Control
Bay11-7082
TMB-8ControlBay11-7082
TMB-8
Increase (fold)Inhibition (%)Inhibition (%)
CCL20 170 93 41 62 0* 
IL-1β 40 70 96 37 66 
Bcl2-A1 68 22 70 0* 
IL-6 98 62 70 37 
COX-2 74 97 60 97 
A20 18 73 44 20 
PAI-2 10 75 98 95 
IL-24 60 98 43 97 
KRT17 55 86 57 81 
RPS25 
GeneTributyrin treated
Untreated
Control
Bay11-7082
TMB-8ControlBay11-7082
TMB-8
Increase (fold)Inhibition (%)Inhibition (%)
CCL20 170 93 41 62 0* 
IL-1β 40 70 96 37 66 
Bcl2-A1 68 22 70 0* 
IL-6 98 62 70 37 
COX-2 74 97 60 97 
A20 18 73 44 20 
PAI-2 10 75 98 95 
IL-24 60 98 43 97 
KRT17 55 86 57 81 
RPS25 

NOTE: Inhibition is defined as percentage of inhibition relative to the control level, which is considered 100%. Human ribosomal protein S25 (RPS25) served as a reference. The experiments were repeated thrice with a similar outcome; the results of one of such study are presented.

*

Induction rather than inhibition, 4-fold for CCL20 and 3-fold for Bcl2-A1.

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