Summary of immunohistochemical staining of ovarian carcinomas with HE4 antibodies
| Intensity of immunostaining* . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Histologic subtytpes | Strong (% diffuse†) | Moderate (% diffuse) | Weak (% diffuse) | Negative | P‡ | |||||
| Papillary serous (n = 60) | 24 (100) | 32 (90) | 4 (75) | 0 | ||||||
| Endometrioid (n = 16) | 12 (100) | 4 (100) | 0 | 0 | 0.014 | |||||
| Mucinous (n = 10) | 0 | 1§ | 0 | 9 | 0.001 | |||||
| Clear cell (n = 6) | 2 (100) | 1 (50) | 0 | 3 | 0.10 | |||||
| Intensity of immunostaining* . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Histologic subtytpes | Strong (% diffuse†) | Moderate (% diffuse) | Weak (% diffuse) | Negative | P‡ | |||||
| Papillary serous (n = 60) | 24 (100) | 32 (90) | 4 (75) | 0 | ||||||
| Endometrioid (n = 16) | 12 (100) | 4 (100) | 0 | 0 | 0.014 | |||||
| Mucinous (n = 10) | 0 | 1§ | 0 | 9 | 0.001 | |||||
| Clear cell (n = 6) | 2 (100) | 1 (50) | 0 | 3 | 0.10 | |||||
All cases were independently reviewed and scored by four pathologists (R.D., C.P.C., W.R.W., J.L.H.).
Diffuse staining is defined as immunoreactivity over ≥75% of the tumor area.
Compares distribution of papillary serous immunostaining with endometriod, mucinous, and clear cell subtypes, using exact version of Kruskal-Wallis nonparametric test for singly ordered RxC contingency (Software: StatXact, version 6.1 2003, Cytel Software).
Represents a high-grade mucinous tumor. HE4 immunoreactivity was present throughout, including stromal components.