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Table 2.

Summary of immunohistochemical staining of ovarian carcinomas with HE4 antibodies

Intensity of immunostaining*
Histologic subtytpes Strong (% diffuseModerate (% diffuse) Weak (% diffuse) Negative P 
Papillary serous (n = 60) 24 (100) 32 (90) 4 (75)  
Endometrioid (n = 16) 12 (100) 4 (100) 0.014 
Mucinous (n = 10) 1§ 0.001 
Clear cell (n = 6) 2 (100) 1 (50) 0.10 
Intensity of immunostaining*
Histologic subtytpes Strong (% diffuseModerate (% diffuse) Weak (% diffuse) Negative P 
Papillary serous (n = 60) 24 (100) 32 (90) 4 (75)  
Endometrioid (n = 16) 12 (100) 4 (100) 0.014 
Mucinous (n = 10) 1§ 0.001 
Clear cell (n = 6) 2 (100) 1 (50) 0.10 
*

All cases were independently reviewed and scored by four pathologists (R.D., C.P.C., W.R.W., J.L.H.).

Diffuse staining is defined as immunoreactivity over ≥75% of the tumor area.

Compares distribution of papillary serous immunostaining with endometriod, mucinous, and clear cell subtypes, using exact version of Kruskal-Wallis nonparametric test for singly ordered RxC contingency (Software: StatXact, version 6.1 2003, Cytel Software).

§

Represents a high-grade mucinous tumor. HE4 immunoreactivity was present throughout, including stromal components.

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