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Table 1.

HE4 protein expression in normal human tissues

Normal tissuesPositive/testedHistological description
Esophagus 0/2  
Stomach 0/4  
Gallbladder 0/5  
Duodenum 0/6  
Colon 0/6  
Pancreas 0/4  
Liver 0/5  
Spleen 0/5  
Lymph node 0/7  
Skeletal muscle 0/4  
Cardiac muscle 0/4  
Lung 1/4 Proximal respiratory epithelium 
Trachea 5/5 Respiratory epithelium and minor salivary glands 
Thyroid 0/6  
Kidney 5/6 Focal in a minority of tubules 
Brain 0/4  
Breast 4/5 Predominantly in secretions with focal reactivity in a minority of ducts 
Ovary 0/7 Negative in OSE; positive in metaplastic, ciliated CICs 
Fallopian tubes 10/10  
Endometrium 4/4  
Cervix 4/4 Endocervical glands only 
Epididymis 5/5 Strongest staining in duct of the epididymis, weaker staining in efferent ducts 
Testes 0/4  
Prostate 4/7 Weak, focal glandular epithelial staining 
Normal tissuesPositive/testedHistological description
Esophagus 0/2  
Stomach 0/4  
Gallbladder 0/5  
Duodenum 0/6  
Colon 0/6  
Pancreas 0/4  
Liver 0/5  
Spleen 0/5  
Lymph node 0/7  
Skeletal muscle 0/4  
Cardiac muscle 0/4  
Lung 1/4 Proximal respiratory epithelium 
Trachea 5/5 Respiratory epithelium and minor salivary glands 
Thyroid 0/6  
Kidney 5/6 Focal in a minority of tubules 
Brain 0/4  
Breast 4/5 Predominantly in secretions with focal reactivity in a minority of ducts 
Ovary 0/7 Negative in OSE; positive in metaplastic, ciliated CICs 
Fallopian tubes 10/10  
Endometrium 4/4  
Cervix 4/4 Endocervical glands only 
Epididymis 5/5 Strongest staining in duct of the epididymis, weaker staining in efferent ducts 
Testes 0/4  
Prostate 4/7 Weak, focal glandular epithelial staining 
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