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Table 1.

Adoptive transfer of WT leukocytes does not increase pulmonary metastasis in CCR5−/− mice

Marker% of Positive cells*% of Dual positive cells (CCR5+)*Dose of adoptively transferred cells (105)No. metastases in CCR5−/− mice following the transfer of
WT cellsCCR5−/− cells
B220 23.9 6.8 50 10.2 ± 1.76 26.7 ± 1.54 
CD11c 11.5 2.3 10§ 17.3 ± 5.93 30.8 ± 6.35 
F4/80 4.7 1.2 5 28.3 ± 2.85  
NK1.1 7.3 0.7 — —  
CD4 6.5 0.6 — —  
CD8 8.4 0.5 — —  
Pan NK 9.6 0.5 — —  
γ chain 1.9 0.2 — —  
Marker% of Positive cells*% of Dual positive cells (CCR5+)*Dose of adoptively transferred cells (105)No. metastases in CCR5−/− mice following the transfer of
WT cellsCCR5−/− cells
B220 23.9 6.8 50 10.2 ± 1.76 26.7 ± 1.54 
CD11c 11.5 2.3 10§ 17.3 ± 5.93 30.8 ± 6.35 
F4/80 4.7 1.2 5 28.3 ± 2.85  
NK1.1 7.3 0.7 — —  
CD4 6.5 0.6 — —  
CD8 8.4 0.5 — —  
Pan NK 9.6 0.5 — —  
γ chain 1.9 0.2 — —  
*

Whole lung cell isolates 3 days after injection with 106 B16-F10 melanoma cells.

Isolated from splenocytes.

CD11c+ were defined as those cells in the second decade that are now recognized as pulmonary dendritic cells (52, 53).

§

Bone marrow derived and expanded in GM-CSF.

Isolated by bronchoalveolar lavage.

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