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Table 3.

Differentially expressed genes in Folbp1+/+ and Folbp1+/− mice

Accession no.SymbolGene descriptionFold change, heterozygous/wild-typeP
Apoptosis     
    NM_010062 DNase2a DNase IIα 0.49 0.01 
    NM_011050 Pdcd4 Programmed cell death 4 0.39 0.01 
    NM_007465 Birc3 Baculoviral IAP repeat-containing 3 0.35 0.02 
Cell adhesion     
    NM_009675 Aoc3 Amine oxidase, copper-containing 3 2.11 0.05 
    NM_008483 Lamb2 Laminin, β2 0.43 0.03 
Cell cycle/cell proliferation     
    NM_013525 Gas5 Growth arrest–specific 5 2.35 0.005 
    AF236887 Atr Ataxia telangiectasia and Rad3 related 0.42 0.03 
    NM_011369 Shcbp1 Shc SH2-domain binding protein 1 0.39 0.02 
    NM_010784 Mdk Midkine 0.38 0.03 
Nucleotide metabolism and transport     
    AB020203 Ak3l Adenylate kinase 3α like 2.66 0.01 
    NM_053103 Lysal2 Lysosomal apyrase-like 2 2.00 0.01 
    NM_007398 Ada Adenosine deaminase 0.45 0.05 
    NM_016690 Hnrpdl Heterogeneous nuclear ribonucleoprotein D like 0.44 0.04 
DNA binding     
    NM_009561 Zfp61 Zinc finger protein 61 0.48 0.04 
    NM_020618 Smarce1 SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily E, member 1 0.45 0.04 
    NM_015781 Nap1l1 Nucleosome assembly protein 1 like 1 0.42 0.01 
    NM_021790 Solt SoxLZ/Sox6 leucine zipper binding protein in testis 0.37 0.04 
RNA binding     
    NM_024199 Cstf1 Cleavage stimulation factor, 3′ pre-RNA, subunit 1 2.05 0.01 
    AK008240 Snrpf Small nuclear ribonucleoprotein polypeptide 0.45 0.04 
Transcription/translation     
    AK011545 Basp1 Neuronal axonal membrane protein (Nap-22) 0.31 0.03 
    NM_009385 Titf1 Thyroid transcription factor 1 2.95 0.02 
    NM_011297 Rps24 Ribosomal protein S24 0.45 0.03 
    D83146 Six5 Sine oculis-related homeobox 5 homologue (Drosophila) 0.43 0.02 
    AK019500 Syncrip Synaptotagmin binding, cytoplasmic RNA interacting protein 0.39 0.01 
    S66855 Hoxb9 Homeobox B9 0.31 0.05 
Eicosanoid     
    NM_010160 Cugbp2 CUG triplet repeat, RNA binding protein 2 0.23 0.02 
    AF233645 Cyp4f15 Cytochrome P450, family 4, subfamily F, polypeptide 15 0.13 0.05 
Glycosylation     
    NM_009178 Siat4c Sialyltransferase 4C (β-galactoside α-2,3-sialytransferase) 3.74 0.02 
    NM_009176 Siat6 Sialyltransferase 6 (N-acetyllacosaminide α-2,3-sialyltransferase) 2.71 0.01 
    NM_028189 B3gnt3 UDP-GlcNAc:βGal β-1,3-N-acetylglucosaminyltransferase 3 2.54 0.005 
    AK006263 Siat10 Sialyltransferase 10 (α-2,3-sialyltransferase VI) 2.29 0.05 
G-protein related     
    AK008273 Arhgdib Rho, GDP dissociation inhibitor (GDI) β 0.32 0.01 
    NM_010336 Edg2 Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 0.32 0.002 
    NM_008376 Imap38 Immunity-associated protein 0.28 0.0004 
Immune function     
    NM_009399 Tnfrsf11a Tumor necrosis factor receptor superfamily, member 11a 4.39 0.02 
    NM_008532 Tacstd1 Tumor-associated calcium signal transducer 1 3.48 0.01 
    NM_007657 Cd9 CD9 antigen 3.39 0.01 
    AJ006130 Ik IK cytokine 0.48 0.003 
    NM_011157 Prg Proteoglycan, secretory granule 0.46 0.003 
    NM_008510 Xcl1 Chemokine (C motif) ligand 1 0.41 0.01 
    NM_017372 Lyzs Lysozyme 0.30 0.03 
    NM_019391 Lsp1 Lymphocyte-specific 1 0.25 0.03 
    NM_013590 Lzp-s P lysozyme structural 0.25 0.04 
    NM_013706 Cd52 CD52 antigen 0.25 0.01 
Kinase/phosphatase     
    NM_026268 Dusp6 Dual-specificity phosphatase 6 2.47 0.05 
    NM_007394 Acvr1 Activin A receptor, type 1 2.19 0.04 
    NM_054097 Pip5k2c Phosphatidylinositol-4-phosphate 5-kinase type II 2.06 0.002 
    NM_008846 Pip5k1a Phosphatidylinositol-4-phosphate 5-kinase type Iα 2.03 0.02 
    AK011110 Riok3 RIO kinase 3 (yeast) 0.48 0.01 
    AK007215 Wdfy1 WD40 and FYVE domain containing 1 0.40 0.01 
Lipid related     
    NM_011868 Peci Peroxisomal 3, 2-enoyl-CoA isomerase 2.79 0.02 
    NM_008094 Gba Glucosidase, β acid 2.49 0.01 
    NM_010941 Nsdhl NAD(P)-dependent steroid dehydrogenase-like 2.28 0.05 
    NM_009415 Tpi Triosephosphate isomerase 2.13 0.02 
    NM_008149 Gpam Glycerol-3-phosphate acyltransferase, mitochondrial 0.46 0.01 
    NM_020573 Osbpl1a Oxysterol binding protein-like 1A 0.30 0.04 
Protein degradation     
    AF303829 Ube2v1 Ubiquitin-conjugating enzyme E2 variant 1 2.15 0.03 
    NM_019562 Uchl5 Ubiquitin carboxyl-terminal esterase L5 0.48 0.02 
    AF098949 Coq7 Demethyl-Q7 0.40 0.001 
    NM_020593 Fbxo3 F-box only protein 3 0.35 0.003 
Amino acid transport/metabolism     
    NM_008577 Slc3a2 Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 2.70 0.003 
    U68526 Bcat2 Branched chain aminotransferase 2, mitochondrial 2.04 0.04 
    NM_025314 Hars2 Histidyl tRNA synthetase 2 0.44 0.01 
Transport     
    U33012 Aqp4 Aquaporin 4 6.25 0.04 
    NM_017474 Clca3 Chloride channel calcium activated 3 6.22 0.001 
    NM_022411 Slc13a2 Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.38 0.02 
    NM_017391 Mrps6 Mitochondrial ribosomal protein S6 2.00 0.02 
    NM_015751 Abce1 ATP-binding cassette, subfamily E (OABP), member 1 0.50 0.02 
    AK005223 Ap1s2 Adaptor-related protein complex 1, 2 subunit 0.24 0.04 
    NM_021301 Slc15a2 Solute carrier family 15 (H+/peptide transporter), member 2 0.14 0.01 
Metabolism     
    NM_007409 Adh1 Alcohol dehydrogenase 1 (class I) 2.80 0.05 
    X03796 Aldo3 Aldolase 3, C isoform 2.28 0.02 
    U27014 Sdh1 Sorbitol dehydrogenase 1 2.05 0.01 
    NM_023113 Aspa Aspartoacylase (aminoacylase) 2 0.41 0.03 
Other     
    NM_053108 Glrx1 Glutaredoxin 1 (thioltransferase) (protein metabolism) 2.43 0.05 
    NM_021895 Actn4 Actinin α4 (actin and calcium binding) 2.43 0.001 
    NM_011503 Stxbp2 Syntaxin binding protein 2 (protein trafficking) 2.36 0.03 
    NM_011222 Pvt1 Plasmacytoma variant translocation 1 (B-cell malignancy) 2.35 0.02 
    NM_019649 Clptm1 Cleft lip and palate associated transmembrane protein 1 (cleft lip) 2.27 0.03 
    AA409743 Tagln2 Transgelin 2 (muscle development) 2.09 0.01 
    NM_007509 Atp6v1b2 ATPase, H+ transporting, V1 subunit B, isoform 2 (ATPase) 2.08 0.04 
    NM_009304 Syngr2 Synaptogyrin 2 (synaptic protein) 2.05 0.05 
    NM_011072 Pfn1 Profilin 1 (actin binding protein) 2.03 0.001 
    NM_016902 Nphp1 Nephronophthisis 1 (juvenile) homologue (human) (kidney disease) 0.50 0.02 
    NM_009311 Tac1 Tachykinin 1 (neural signaling) 0.50 0.03 
    NM_009441 Ttc3 Tetratricopeptide repeat domain 3 (pathogenesis) 0.48 0.04 
    NM_009804 Cat Catalase (antioxidant) 0.46 0.02 
    AK011899 Tbce Tubulin-specific chaperone (tubulin folding) 0.44 0.05 
    NM_008017 Smc2l1 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) (chromosomal protein) 0.43 0.04 
    NM_011169 Prlr Prolactin receptor (receptor) 0.40 0.003 
    NM_026352 Ppid Peptidylprolyl isomerase D (cyclophilin D) (protein folding) 0.39 0.01 
    D00208 S100a4 S100 calcium binding protein A4 (calcium binding) 0.39 0.003 
    NM_019939 Mpp6 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (cell polarity) 0.27 0.04 
Accession no.SymbolGene descriptionFold change, heterozygous/wild-typeP
Apoptosis     
    NM_010062 DNase2a DNase IIα 0.49 0.01 
    NM_011050 Pdcd4 Programmed cell death 4 0.39 0.01 
    NM_007465 Birc3 Baculoviral IAP repeat-containing 3 0.35 0.02 
Cell adhesion     
    NM_009675 Aoc3 Amine oxidase, copper-containing 3 2.11 0.05 
    NM_008483 Lamb2 Laminin, β2 0.43 0.03 
Cell cycle/cell proliferation     
    NM_013525 Gas5 Growth arrest–specific 5 2.35 0.005 
    AF236887 Atr Ataxia telangiectasia and Rad3 related 0.42 0.03 
    NM_011369 Shcbp1 Shc SH2-domain binding protein 1 0.39 0.02 
    NM_010784 Mdk Midkine 0.38 0.03 
Nucleotide metabolism and transport     
    AB020203 Ak3l Adenylate kinase 3α like 2.66 0.01 
    NM_053103 Lysal2 Lysosomal apyrase-like 2 2.00 0.01 
    NM_007398 Ada Adenosine deaminase 0.45 0.05 
    NM_016690 Hnrpdl Heterogeneous nuclear ribonucleoprotein D like 0.44 0.04 
DNA binding     
    NM_009561 Zfp61 Zinc finger protein 61 0.48 0.04 
    NM_020618 Smarce1 SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily E, member 1 0.45 0.04 
    NM_015781 Nap1l1 Nucleosome assembly protein 1 like 1 0.42 0.01 
    NM_021790 Solt SoxLZ/Sox6 leucine zipper binding protein in testis 0.37 0.04 
RNA binding     
    NM_024199 Cstf1 Cleavage stimulation factor, 3′ pre-RNA, subunit 1 2.05 0.01 
    AK008240 Snrpf Small nuclear ribonucleoprotein polypeptide 0.45 0.04 
Transcription/translation     
    AK011545 Basp1 Neuronal axonal membrane protein (Nap-22) 0.31 0.03 
    NM_009385 Titf1 Thyroid transcription factor 1 2.95 0.02 
    NM_011297 Rps24 Ribosomal protein S24 0.45 0.03 
    D83146 Six5 Sine oculis-related homeobox 5 homologue (Drosophila) 0.43 0.02 
    AK019500 Syncrip Synaptotagmin binding, cytoplasmic RNA interacting protein 0.39 0.01 
    S66855 Hoxb9 Homeobox B9 0.31 0.05 
Eicosanoid     
    NM_010160 Cugbp2 CUG triplet repeat, RNA binding protein 2 0.23 0.02 
    AF233645 Cyp4f15 Cytochrome P450, family 4, subfamily F, polypeptide 15 0.13 0.05 
Glycosylation     
    NM_009178 Siat4c Sialyltransferase 4C (β-galactoside α-2,3-sialytransferase) 3.74 0.02 
    NM_009176 Siat6 Sialyltransferase 6 (N-acetyllacosaminide α-2,3-sialyltransferase) 2.71 0.01 
    NM_028189 B3gnt3 UDP-GlcNAc:βGal β-1,3-N-acetylglucosaminyltransferase 3 2.54 0.005 
    AK006263 Siat10 Sialyltransferase 10 (α-2,3-sialyltransferase VI) 2.29 0.05 
G-protein related     
    AK008273 Arhgdib Rho, GDP dissociation inhibitor (GDI) β 0.32 0.01 
    NM_010336 Edg2 Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 0.32 0.002 
    NM_008376 Imap38 Immunity-associated protein 0.28 0.0004 
Immune function     
    NM_009399 Tnfrsf11a Tumor necrosis factor receptor superfamily, member 11a 4.39 0.02 
    NM_008532 Tacstd1 Tumor-associated calcium signal transducer 1 3.48 0.01 
    NM_007657 Cd9 CD9 antigen 3.39 0.01 
    AJ006130 Ik IK cytokine 0.48 0.003 
    NM_011157 Prg Proteoglycan, secretory granule 0.46 0.003 
    NM_008510 Xcl1 Chemokine (C motif) ligand 1 0.41 0.01 
    NM_017372 Lyzs Lysozyme 0.30 0.03 
    NM_019391 Lsp1 Lymphocyte-specific 1 0.25 0.03 
    NM_013590 Lzp-s P lysozyme structural 0.25 0.04 
    NM_013706 Cd52 CD52 antigen 0.25 0.01 
Kinase/phosphatase     
    NM_026268 Dusp6 Dual-specificity phosphatase 6 2.47 0.05 
    NM_007394 Acvr1 Activin A receptor, type 1 2.19 0.04 
    NM_054097 Pip5k2c Phosphatidylinositol-4-phosphate 5-kinase type II 2.06 0.002 
    NM_008846 Pip5k1a Phosphatidylinositol-4-phosphate 5-kinase type Iα 2.03 0.02 
    AK011110 Riok3 RIO kinase 3 (yeast) 0.48 0.01 
    AK007215 Wdfy1 WD40 and FYVE domain containing 1 0.40 0.01 
Lipid related     
    NM_011868 Peci Peroxisomal 3, 2-enoyl-CoA isomerase 2.79 0.02 
    NM_008094 Gba Glucosidase, β acid 2.49 0.01 
    NM_010941 Nsdhl NAD(P)-dependent steroid dehydrogenase-like 2.28 0.05 
    NM_009415 Tpi Triosephosphate isomerase 2.13 0.02 
    NM_008149 Gpam Glycerol-3-phosphate acyltransferase, mitochondrial 0.46 0.01 
    NM_020573 Osbpl1a Oxysterol binding protein-like 1A 0.30 0.04 
Protein degradation     
    AF303829 Ube2v1 Ubiquitin-conjugating enzyme E2 variant 1 2.15 0.03 
    NM_019562 Uchl5 Ubiquitin carboxyl-terminal esterase L5 0.48 0.02 
    AF098949 Coq7 Demethyl-Q7 0.40 0.001 
    NM_020593 Fbxo3 F-box only protein 3 0.35 0.003 
Amino acid transport/metabolism     
    NM_008577 Slc3a2 Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 2.70 0.003 
    U68526 Bcat2 Branched chain aminotransferase 2, mitochondrial 2.04 0.04 
    NM_025314 Hars2 Histidyl tRNA synthetase 2 0.44 0.01 
Transport     
    U33012 Aqp4 Aquaporin 4 6.25 0.04 
    NM_017474 Clca3 Chloride channel calcium activated 3 6.22 0.001 
    NM_022411 Slc13a2 Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.38 0.02 
    NM_017391 Mrps6 Mitochondrial ribosomal protein S6 2.00 0.02 
    NM_015751 Abce1 ATP-binding cassette, subfamily E (OABP), member 1 0.50 0.02 
    AK005223 Ap1s2 Adaptor-related protein complex 1, 2 subunit 0.24 0.04 
    NM_021301 Slc15a2 Solute carrier family 15 (H+/peptide transporter), member 2 0.14 0.01 
Metabolism     
    NM_007409 Adh1 Alcohol dehydrogenase 1 (class I) 2.80 0.05 
    X03796 Aldo3 Aldolase 3, C isoform 2.28 0.02 
    U27014 Sdh1 Sorbitol dehydrogenase 1 2.05 0.01 
    NM_023113 Aspa Aspartoacylase (aminoacylase) 2 0.41 0.03 
Other     
    NM_053108 Glrx1 Glutaredoxin 1 (thioltransferase) (protein metabolism) 2.43 0.05 
    NM_021895 Actn4 Actinin α4 (actin and calcium binding) 2.43 0.001 
    NM_011503 Stxbp2 Syntaxin binding protein 2 (protein trafficking) 2.36 0.03 
    NM_011222 Pvt1 Plasmacytoma variant translocation 1 (B-cell malignancy) 2.35 0.02 
    NM_019649 Clptm1 Cleft lip and palate associated transmembrane protein 1 (cleft lip) 2.27 0.03 
    AA409743 Tagln2 Transgelin 2 (muscle development) 2.09 0.01 
    NM_007509 Atp6v1b2 ATPase, H+ transporting, V1 subunit B, isoform 2 (ATPase) 2.08 0.04 
    NM_009304 Syngr2 Synaptogyrin 2 (synaptic protein) 2.05 0.05 
    NM_011072 Pfn1 Profilin 1 (actin binding protein) 2.03 0.001 
    NM_016902 Nphp1 Nephronophthisis 1 (juvenile) homologue (human) (kidney disease) 0.50 0.02 
    NM_009311 Tac1 Tachykinin 1 (neural signaling) 0.50 0.03 
    NM_009441 Ttc3 Tetratricopeptide repeat domain 3 (pathogenesis) 0.48 0.04 
    NM_009804 Cat Catalase (antioxidant) 0.46 0.02 
    AK011899 Tbce Tubulin-specific chaperone (tubulin folding) 0.44 0.05 
    NM_008017 Smc2l1 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) (chromosomal protein) 0.43 0.04 
    NM_011169 Prlr Prolactin receptor (receptor) 0.40 0.003 
    NM_026352 Ppid Peptidylprolyl isomerase D (cyclophilin D) (protein folding) 0.39 0.01 
    D00208 S100a4 S100 calcium binding protein A4 (calcium binding) 0.39 0.003 
    NM_019939 Mpp6 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (cell polarity) 0.27 0.04 

NOTE: Genes were selected based on a significant (P < 0.05) and a minimum 2-fold change in expression. From each genotype, colonic mucosa from three noninjected (100-day-old baseline) mice was collected and processed for RNA isolation. Fold change is the normalized signal intensity of a given gene in Folbp1+/− (heterozygous) relative to Folbp1+/+ (wild-type) mice.

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