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Table 3.

A multivariate Cox proportional hazards model for cyclin A2, cyclin D1, CCND1 status and treatment interaction

VariableRecurrence free survival
Overall survival
RR (95% CI)PRR (95% CI)P
D1 NF Low versus high 0.94 (0.62-1.44) 0.79 0.85 (0.54-1.34) 0.49 
    Treatment Tamoxifen versus control 0.67 (0.39-1.12) 0.13 0.67 (0.38-1.19) 0.17 
    Interaction variable Tamoxifen × D1 nf 0.88 (0.44-1.79) 0.74 1.12 (0.53-2.37) 0.76 
D1 NI Low/moderate versus high 0.80 (0.36-1.74) 0.57 0.96 (0.44-2-20) 0.92 
    Treatment Tamoxifen versus control 0.62 (0.42-0.88) 0.009 0.73 (0.49-1.08) 0.11 
    Interaction variable Tamoxifen × D1 ni 1.18 (0.40-3.50) 0.77 0.84 (0.27-2.58) 0.76 
A2 NF Low versus high 0.97 (0.58-1.62) 0.92 1.12 (0.65-1.93) 0.68 
    Treatment Tamoxifen versus control 0.48 (0.28-0.82) 0.007 0.68 (0.39-1.19) 0.18 
    Interaction variable Tamoxifen × A2 nf 1.78 (0.83-3.79) 0.14 1.25 (.57-2.75) 0.58 
CCND1 Amplified versus nonamplified 0.57 (0.27-1.22) 0.15 0.82 (0.30-1.79) 0.62 
    Treatment Tamoxifen versus control 0.39 (0.23-0.65) <0.001 0.41 (0.22-0.75) 0.004 
    Interaction variable Tamoxifen × CCND1 6.38 (2.29-17.78) <0.001 5.34 (1.84-15.51) 0.002 
VariableRecurrence free survival
Overall survival
RR (95% CI)PRR (95% CI)P
D1 NF Low versus high 0.94 (0.62-1.44) 0.79 0.85 (0.54-1.34) 0.49 
    Treatment Tamoxifen versus control 0.67 (0.39-1.12) 0.13 0.67 (0.38-1.19) 0.17 
    Interaction variable Tamoxifen × D1 nf 0.88 (0.44-1.79) 0.74 1.12 (0.53-2.37) 0.76 
D1 NI Low/moderate versus high 0.80 (0.36-1.74) 0.57 0.96 (0.44-2-20) 0.92 
    Treatment Tamoxifen versus control 0.62 (0.42-0.88) 0.009 0.73 (0.49-1.08) 0.11 
    Interaction variable Tamoxifen × D1 ni 1.18 (0.40-3.50) 0.77 0.84 (0.27-2.58) 0.76 
A2 NF Low versus high 0.97 (0.58-1.62) 0.92 1.12 (0.65-1.93) 0.68 
    Treatment Tamoxifen versus control 0.48 (0.28-0.82) 0.007 0.68 (0.39-1.19) 0.18 
    Interaction variable Tamoxifen × A2 nf 1.78 (0.83-3.79) 0.14 1.25 (.57-2.75) 0.58 
CCND1 Amplified versus nonamplified 0.57 (0.27-1.22) 0.15 0.82 (0.30-1.79) 0.62 
    Treatment Tamoxifen versus control 0.39 (0.23-0.65) <0.001 0.41 (0.22-0.75) 0.004 
    Interaction variable Tamoxifen × CCND1 6.38 (2.29-17.78) <0.001 5.34 (1.84-15.51) 0.002 

NOTE: Adjusted for age (continuous), tumor size (continuous), NHG (1 + 2 versus 3), and nodal status (0 versus 1).

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