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Table 2.

Summary of avidity and isotype of anti-HER2 antibodies

Immunoglobulin levels (μg/mL)
% Avidity
HER2 lgGlgG1lgG2lgG3lgG4
9.26 0.00 0.00 1.84 0.38 1.3 
4.41 1.94 0.00 1.83 0.00 17.9 
8.40 4.66 1.96 0.85 0.38 9.6 
1.81 0.00 0.00 0.25 0.00 
1.90 0.00 0.00 1.34 0.00 
8.00 3.14 3.56 0.93 0.00 3.4 
2.00     
1.54 0.00 0.00 0.64 0.26 2.3 
2.50 0.00 2.49 0.93 0.15 2.1 
10 1.20     — 
11 1.2 0.88 
Immunoglobulin levels (μg/mL)
% Avidity
HER2 lgGlgG1lgG2lgG3lgG4
9.26 0.00 0.00 1.84 0.38 1.3 
4.41 1.94 0.00 1.83 0.00 17.9 
8.40 4.66 1.96 0.85 0.38 9.6 
1.81 0.00 0.00 0.25 0.00 
1.90 0.00 0.00 1.34 0.00 
8.00 3.14 3.56 0.93 0.00 3.4 
2.00     
1.54 0.00 0.00 0.64 0.26 2.3 
2.50 0.00 2.49 0.93 0.15 2.1 
10 1.20     — 
11 1.2 0.88 

NOTE: Levels of antibody, avidity, and isotype of serum antibodies from patients with anti-HER2 responses was determined as defined in Materials and Methods. Inadequate amounts of serum were available to fully characterize some samples.

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