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Table 3.

Microvessel density, area of the vessels, and tumor infiltration after isolated perfusion with sham, IL-2, melphalan, or IL-2 plus melphalan

ShamIL-2MelphalanIL-2 + melphalan
No. vessels* 33 ± 9 64 ± 24 22 ± 2 29 ± 5 
Area of endothelium 6.8 ± 0.6 9.2 ± 1.3 5.9 ± 0.9 6.4 ± 0.8 
Area endothelium/vessel 0.30 ± 0.09 0.16 ± 0.04 0.28 ± 0.03 0.24 ± 0.02 
CD4§ 0.4 ± 0.2 2.4 ± 0.2 0.2 ± 0.2 0.1 ± 0.1 
CD8§ 51 ± 7 36 ± 10 67 ± 47 37 ± 10 
Granulocytes§ 60 ± 4 79 ± 4 48 ± 3 63 ± 4 
Macrophages§ 210 ± 7 222 ± 52 201 ± 20 189 ± 20 
ShamIL-2MelphalanIL-2 + melphalan
No. vessels* 33 ± 9 64 ± 24 22 ± 2 29 ± 5 
Area of endothelium 6.8 ± 0.6 9.2 ± 1.3 5.9 ± 0.9 6.4 ± 0.8 
Area endothelium/vessel 0.30 ± 0.09 0.16 ± 0.04 0.28 ± 0.03 0.24 ± 0.02 
CD4§ 0.4 ± 0.2 2.4 ± 0.2 0.2 ± 0.2 0.1 ± 0.1 
CD8§ 51 ± 7 36 ± 10 67 ± 47 37 ± 10 
Granulocytes§ 60 ± 4 79 ± 4 48 ± 3 63 ± 4 
Macrophages§ 210 ± 7 222 ± 52 201 ± 20 189 ± 20 

NOTE: Directly after ILP, the tumors were excised and frozen sections were stained for granulocytes, macrophages, and CD31-, CD4-, and CD8-positive cells. At least two animals per group and six fields of interest per tumor were evaluated. Average ± SE is shown.

*

No. vessels per field of interest.

% Total vessel area per field of interest.

Area per vessel.

§

Amount of positive cells per field of interest.

P = 0.05 compared with sham treatment.

P = 0.05 compared with melphalan treatment.

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