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Table 1.

Summary panel: BPA uncouples androgen-mediated AR transactivation from mitogenesis in prostate cancer cells

Transcription
Mitogenesis
DHT++
AR+, AD prostate cancer cells (LNCaP or LAPC-4) BPA, low dose ↑ ↑↑↑ ↑ No effect 
 BPA, high dose No effect ↑↑ ↓↓↓ ↓↓ 
AR+, AI prostate cancer cells (22Rv-1) BPA, low dose ↑ ↑↑ No effect No effect 
 BPA, high dose ↑↑ ↑↑ ↓ ↓ 
AR−/−, AI prostate cancer cells (PC-3, DU-145) BPA, low dose N/A N/A No effect No effect 
 BPA, high dose N/A N/A No effect No effect 
Transcription
Mitogenesis
DHT++
AR+, AD prostate cancer cells (LNCaP or LAPC-4) BPA, low dose ↑ ↑↑↑ ↑ No effect 
 BPA, high dose No effect ↑↑ ↓↓↓ ↓↓ 
AR+, AI prostate cancer cells (22Rv-1) BPA, low dose ↑ ↑↑ No effect No effect 
 BPA, high dose ↑↑ ↑↑ ↓ ↓ 
AR−/−, AI prostate cancer cells (PC-3, DU-145) BPA, low dose N/A N/A No effect No effect 
 BPA, high dose N/A N/A No effect No effect 

NOTE: Transcriptional activity score: ↑, partial activity; ↑↑, moderate activity; ↑↑↑, enhanced activity. Effect on mitogenesis: ↑, partial induction; ↓, partial inhibition; ↓↓, moderate inhibition; ↓↓↓, complete inhibition. Low dose: 10−9 and 10−8 mol/L as indicated in the text. High dose: 10−6 and 10−5 mol/L as indicated in the text. Abbreviations: AD, androgen dependent; AI, androgen independent, N/A, not applicable.

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