Summary panel: BPA uncouples androgen-mediated AR transactivation from mitogenesis in prostate cancer cells
| . | . | Transcription . | . | Mitogenesis . | . | ||
|---|---|---|---|---|---|---|---|
| . | DHT . | − . | + . | − . | + . | ||
| AR+, AD prostate cancer cells (LNCaP or LAPC-4) | BPA, low dose | ↑ | ↑↑↑ | ↑ | No effect | ||
| BPA, high dose | No effect | ↑↑ | ↓↓↓ | ↓↓ | |||
| AR+, AI prostate cancer cells (22Rv-1) | BPA, low dose | ↑ | ↑↑ | No effect | No effect | ||
| BPA, high dose | ↑↑ | ↑↑ | ↓ | ↓ | |||
| AR−/−, AI prostate cancer cells (PC-3, DU-145) | BPA, low dose | N/A | N/A | No effect | No effect | ||
| BPA, high dose | N/A | N/A | No effect | No effect | |||
| . | . | Transcription . | . | Mitogenesis . | . | ||
|---|---|---|---|---|---|---|---|
| . | DHT . | − . | + . | − . | + . | ||
| AR+, AD prostate cancer cells (LNCaP or LAPC-4) | BPA, low dose | ↑ | ↑↑↑ | ↑ | No effect | ||
| BPA, high dose | No effect | ↑↑ | ↓↓↓ | ↓↓ | |||
| AR+, AI prostate cancer cells (22Rv-1) | BPA, low dose | ↑ | ↑↑ | No effect | No effect | ||
| BPA, high dose | ↑↑ | ↑↑ | ↓ | ↓ | |||
| AR−/−, AI prostate cancer cells (PC-3, DU-145) | BPA, low dose | N/A | N/A | No effect | No effect | ||
| BPA, high dose | N/A | N/A | No effect | No effect | |||
NOTE: Transcriptional activity score: ↑, partial activity; ↑↑, moderate activity; ↑↑↑, enhanced activity. Effect on mitogenesis: ↑, partial induction; ↓, partial inhibition; ↓↓, moderate inhibition; ↓↓↓, complete inhibition. Low dose: 10−9 and 10−8 mol/L as indicated in the text. High dose: 10−6 and 10−5 mol/L as indicated in the text. Abbreviations: AD, androgen dependent; AI, androgen independent, N/A, not applicable.