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Table 2

Risk of pancreatic cancer among unrelated family members and among individuals with a first-degree relative with pancreatic cancer in the familial (FPC) kindreds and sporadic (SPC) kindreds

Family statusaNo. of individualsPerson-years of follow-upObserved casesExpected casesbSIRc (95% CI)
FPC Kindreds 1993 5273 11 1.22 9.0 (4.5–16.1) 
SPC Kindreds 1964 5265 1.12 1.8 (0.22–6.42) 
Unrelated 369 1073 0.41 2.4 (0.06–13.5) 
Family statusaNo. of individualsPerson-years of follow-upObserved casesExpected casesbSIRc (95% CI)
FPC Kindreds 1993 5273 11 1.22 9.0 (4.5–16.1) 
SPC Kindreds 1964 5265 1.12 1.8 (0.22–6.42) 
Unrelated 369 1073 0.41 2.4 (0.06–13.5) 
a

FPC kindreds were defined as kindreds having at least one pair of first-degree relatives with pancreatic cancer, and SPC kindreds as families without such an affected pair.

b

Adjusted for age, sex, and race.

c

SIR, standardized incidence ratio; CI, confidence interval.

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