Response of NF-κB-inducible and p53-responsive genes to camptothecin
A. NF-κB-inducible genes . | . | . | B. p53-responsive genes . | . | . | ||||
---|---|---|---|---|---|---|---|---|---|
Gene symbol . | False discovery rate . | Fold Change . | Gene symbol . | False discovery rate . | Fold Change . | ||||
CCL20 | 1.39 × 10−3 | 17.9 | DTR | 6.95 × 10−8 | 8.0 | ||||
IL8 | 2.65 × 10−3 | 11.0 | DKK1 | 6.95 × 10−8 | 6.6 | ||||
PTX3 | 1.08 × 10−2 | 4.4 | ATF3 | 6.95 × 10−8 | 6.6 | ||||
CXCL1 | 2.75 × 10−3 | 3.8 | GADD45B | 2.37 × 10−6 | 6.1 | ||||
BDKRB1 | 5.28 × 10−3 | 3.1 | GADD45A | 1.85 × 10−6 | 5.0 | ||||
NFKB2 | 6.37 × 10−2 | 3.0 | ENC1 | 8.31 × 10−6 | 4.9 | ||||
NFKBIA | 1.47 × 10−4 | 3.0 | PMAIP1 | 7.40 × 10−7 | 4.8 | ||||
BIRC3 | 1.65 × 10−2 | 2.7 | IGFBP3 | 2.10 × 10−4 | 2.6 | ||||
IL6 | 7.63 × 10−5 | 2.7 | CDKN1A | 1.31 × 10−3 | 2.1 | ||||
BLR1 | 1.32 × 10−1 | 2.6 | BTG2 | 4.05 × 10−3 | 1.9 | ||||
IL1A | 2.36 × 10−2 | 2.3 | TAX1BP2 | 4.63 × 10−1 | 1.6 | ||||
WT1 | 2.47 × 10−1 | 2.2 | LRDD | 5.74 × 10−1 | 1.4 | ||||
IRF1 | 7.71 × 10−4 | 2.2 | BBC3 | 4.74 × 10−1 | 1.4 | ||||
MYB | 2.90 × 10−1 | 2.2 | PIG8 | 2.26 × 10−1 | 1.3 | ||||
TNFAIP3 | 1.21 × 10−3 | 2.2 | PCNA | 2.09 × 10−1 | 1.3 | ||||
SOD2 | 2.76 × 10−1 | 2.2 | TNFRSF10B | 1.95 × 10−1 | 1.3 | ||||
CCND1 | 4.69 × 10−3 | 2.1 | PTGES | 2.41 × 10−1 | 1.3 | ||||
TNF | 3.52 × 10−1 | 2.0 | PIGPC1 | 5.75 × 10−1 | 1.2 | ||||
HLA-E | 2.25 × 10−3 | 1.8 | GAMT | 8.11 × 10−1 | 1.1 | ||||
HLA-F | 1.09 × 10−2 | 1.7 | PIG4 (GSAA) | 8.98 × 10−1 | 1.1 | ||||
CSF1 | 2.98 × 10−2 | 1.7 | PIG11 | 9.98 × 10−1 | 1.0 | ||||
HLA-B | 2.18 × 10−2 | 1.6 | PIG7 | 9.08 × 10−1 | −1.0 | ||||
ICAM1 | 2.47 × 10−1 | 1.6 | PIG3 | 5.34 × 10−1 | −1.2 | ||||
VCAM1 | 4.63 × 10−1 | 1.5 | LGALS7 | 8.19 × 10−1 | −1.3 | ||||
HLA-G | 5.25 × 10−2 | 1.5 | PRODH | 6.24 × 10−1 | −1.5 | ||||
MMP1 | 6.59 × 10−1 | 1.5 | BAX | 2.41 × 10−1 | −1.6 | ||||
TAP1 | 9.42 × 10−2 | 1.5 | MGC21654 | 1.15 × 10−1 | −1.8 | ||||
HLA-C | 3.26 × 10−2 | 1.5 | PIG5 | 1.10 × 10−1 | −1.8 | ||||
TNFRSF6 | 1.38 × 10−1 | 1.5 | APAF1 | 8.80 × 10−1 | −1.9 | ||||
IL12A | 5.06 × 10−1 | 1.4 | MDM2 | 2.91 × 10−1 | −3.0 | ||||
IL2RA | 6.26 × 10−1 | 1.4 | PTEN | 6.04 × 10−4 | −3.1 | ||||
PSMB9 | 3.91 × 10−1 | 1.4 | |||||||
TNFSF6 | 6.28 × 10−1 | 1.3 | |||||||
PSMD2 | 7.83 × 10−2 | 1.3 | |||||||
HLA-A | 2.42 × 10−1 | 1.3 | |||||||
NOS2A | 7.71 × 10−1 | 1.2 | |||||||
BIRC2 | 4.86 × 10−1 | 1.2 | |||||||
PTGS2 | 7.53 × 10−1 | 1.2 | |||||||
LAMB2 | 5.65 × 10−1 | 1.2 | |||||||
CDKN2A | 3.02 × 10−1 | 1.2 | |||||||
IL2 | 8.96 × 10−1 | 1.2 | |||||||
TRAF1 | 8.88 × 10−1 | 1.1 | |||||||
MYC | 7.20 × 10−1 | 1.1 | |||||||
MMP9 | 9.12 × 10−1 | 1.1 | |||||||
SELE | 9.65 × 10−1 | 1.1 | |||||||
MADCAM1 | 9.86 × 10−1 | 1.0 | |||||||
TP53 | 9.97 × 10−1 | −1.0 | |||||||
IFNB1 | 9.78 × 10−1 | −1.0 | |||||||
F3 | 7.82 × 10−1 | −1.1 | |||||||
CSF2 | 8.85 × 10−1 | −1.2 | |||||||
BIRC4 | 5.64 × 10−1 | −1.3 | |||||||
TRAF2 | 2.46 × 10−1 | −1.4 | |||||||
SERPINE1 | 2.72 × 10−1 | −1.5 | |||||||
NFKB1 | 3.92 × 10−2 | −1.6 | |||||||
BCL2A1 | 6.05 × 10−1 | −1.7 | |||||||
ABCB1 | 5.26 × 10−1 | −1.7 |
A. NF-κB-inducible genes . | . | . | B. p53-responsive genes . | . | . | ||||
---|---|---|---|---|---|---|---|---|---|
Gene symbol . | False discovery rate . | Fold Change . | Gene symbol . | False discovery rate . | Fold Change . | ||||
CCL20 | 1.39 × 10−3 | 17.9 | DTR | 6.95 × 10−8 | 8.0 | ||||
IL8 | 2.65 × 10−3 | 11.0 | DKK1 | 6.95 × 10−8 | 6.6 | ||||
PTX3 | 1.08 × 10−2 | 4.4 | ATF3 | 6.95 × 10−8 | 6.6 | ||||
CXCL1 | 2.75 × 10−3 | 3.8 | GADD45B | 2.37 × 10−6 | 6.1 | ||||
BDKRB1 | 5.28 × 10−3 | 3.1 | GADD45A | 1.85 × 10−6 | 5.0 | ||||
NFKB2 | 6.37 × 10−2 | 3.0 | ENC1 | 8.31 × 10−6 | 4.9 | ||||
NFKBIA | 1.47 × 10−4 | 3.0 | PMAIP1 | 7.40 × 10−7 | 4.8 | ||||
BIRC3 | 1.65 × 10−2 | 2.7 | IGFBP3 | 2.10 × 10−4 | 2.6 | ||||
IL6 | 7.63 × 10−5 | 2.7 | CDKN1A | 1.31 × 10−3 | 2.1 | ||||
BLR1 | 1.32 × 10−1 | 2.6 | BTG2 | 4.05 × 10−3 | 1.9 | ||||
IL1A | 2.36 × 10−2 | 2.3 | TAX1BP2 | 4.63 × 10−1 | 1.6 | ||||
WT1 | 2.47 × 10−1 | 2.2 | LRDD | 5.74 × 10−1 | 1.4 | ||||
IRF1 | 7.71 × 10−4 | 2.2 | BBC3 | 4.74 × 10−1 | 1.4 | ||||
MYB | 2.90 × 10−1 | 2.2 | PIG8 | 2.26 × 10−1 | 1.3 | ||||
TNFAIP3 | 1.21 × 10−3 | 2.2 | PCNA | 2.09 × 10−1 | 1.3 | ||||
SOD2 | 2.76 × 10−1 | 2.2 | TNFRSF10B | 1.95 × 10−1 | 1.3 | ||||
CCND1 | 4.69 × 10−3 | 2.1 | PTGES | 2.41 × 10−1 | 1.3 | ||||
TNF | 3.52 × 10−1 | 2.0 | PIGPC1 | 5.75 × 10−1 | 1.2 | ||||
HLA-E | 2.25 × 10−3 | 1.8 | GAMT | 8.11 × 10−1 | 1.1 | ||||
HLA-F | 1.09 × 10−2 | 1.7 | PIG4 (GSAA) | 8.98 × 10−1 | 1.1 | ||||
CSF1 | 2.98 × 10−2 | 1.7 | PIG11 | 9.98 × 10−1 | 1.0 | ||||
HLA-B | 2.18 × 10−2 | 1.6 | PIG7 | 9.08 × 10−1 | −1.0 | ||||
ICAM1 | 2.47 × 10−1 | 1.6 | PIG3 | 5.34 × 10−1 | −1.2 | ||||
VCAM1 | 4.63 × 10−1 | 1.5 | LGALS7 | 8.19 × 10−1 | −1.3 | ||||
HLA-G | 5.25 × 10−2 | 1.5 | PRODH | 6.24 × 10−1 | −1.5 | ||||
MMP1 | 6.59 × 10−1 | 1.5 | BAX | 2.41 × 10−1 | −1.6 | ||||
TAP1 | 9.42 × 10−2 | 1.5 | MGC21654 | 1.15 × 10−1 | −1.8 | ||||
HLA-C | 3.26 × 10−2 | 1.5 | PIG5 | 1.10 × 10−1 | −1.8 | ||||
TNFRSF6 | 1.38 × 10−1 | 1.5 | APAF1 | 8.80 × 10−1 | −1.9 | ||||
IL12A | 5.06 × 10−1 | 1.4 | MDM2 | 2.91 × 10−1 | −3.0 | ||||
IL2RA | 6.26 × 10−1 | 1.4 | PTEN | 6.04 × 10−4 | −3.1 | ||||
PSMB9 | 3.91 × 10−1 | 1.4 | |||||||
TNFSF6 | 6.28 × 10−1 | 1.3 | |||||||
PSMD2 | 7.83 × 10−2 | 1.3 | |||||||
HLA-A | 2.42 × 10−1 | 1.3 | |||||||
NOS2A | 7.71 × 10−1 | 1.2 | |||||||
BIRC2 | 4.86 × 10−1 | 1.2 | |||||||
PTGS2 | 7.53 × 10−1 | 1.2 | |||||||
LAMB2 | 5.65 × 10−1 | 1.2 | |||||||
CDKN2A | 3.02 × 10−1 | 1.2 | |||||||
IL2 | 8.96 × 10−1 | 1.2 | |||||||
TRAF1 | 8.88 × 10−1 | 1.1 | |||||||
MYC | 7.20 × 10−1 | 1.1 | |||||||
MMP9 | 9.12 × 10−1 | 1.1 | |||||||
SELE | 9.65 × 10−1 | 1.1 | |||||||
MADCAM1 | 9.86 × 10−1 | 1.0 | |||||||
TP53 | 9.97 × 10−1 | −1.0 | |||||||
IFNB1 | 9.78 × 10−1 | −1.0 | |||||||
F3 | 7.82 × 10−1 | −1.1 | |||||||
CSF2 | 8.85 × 10−1 | −1.2 | |||||||
BIRC4 | 5.64 × 10−1 | −1.3 | |||||||
TRAF2 | 2.46 × 10−1 | −1.4 | |||||||
SERPINE1 | 2.72 × 10−1 | −1.5 | |||||||
NFKB1 | 3.92 × 10−2 | −1.6 | |||||||
BCL2A1 | 6.05 × 10−1 | −1.7 | |||||||
ABCB1 | 5.26 × 10−1 | −1.7 |