American Association for Cancer Research

Table 2

Summary of promoter region methylation status in normal and in ductal carcinoma in situ (DCIS) and invasive breast cancer tissue correlated with protein expression^a

	Upstream	Downstream	Expression status	Prevalence^b
Normal	U/M^c	U	+

DCIS	U	U	+	5/8
	M	U	+	2/8
	M	M	−	1/8

Invasive	U	M	−	2/12
	M	U	+	2/12
	M	M	−	7/12
	U	U	+	2/12

	Upstream	Downstream	Expression status	Prevalence^b
Normal	U/M^c	U	+

DCIS	U	U	+	5/8
	M	U	+	2/8
	M	M	−	1/8

Invasive	U	M	−	2/12
	M	U	+	2/12
	M	M	−	7/12
	U	U	+	2/12

The designation of a tumor as positive for methylation, M, means a distinct band for the methylated MSP product was observed as shown in figure 4.

Prevalence for composite changes (number of samples demonstrating specified characteristics/total number of samples).

U, unmethylated; M, methylated.

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