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Table 2

Genes regulated by wild-type cyclic AMP-responsive element binding (CREB) at hypoxia and by CREB300/310 at normoxia

The CREB-regulated genes are arranged according to the fold of change (≥2.1 with a P ≤0.0025) induced by CREB300/310 (m) at normoxia (N) relative to wild-type CREB (wt) at normoxia (N). The effect of hypoxia on wild-type CREB-mediated genes was determined by comparison of gene expression at hypoxia to normoxia (Hwt/Nwt).

AffylDAccession no.SymbolNameNmt/NwtHwt/Nwt
Up-regulated by CREB      
 92830_s_at X14678 Zfp36 Zinc finger protein 36 11.3 9.8 
 101857_at AB006036 Srpk2 Serine/arginine-rich protein-specific kinase 2 6.1 
 160618_at AA760613 Lgals8 Lectin, galactose binding, soluble 8 
 99350_at C76102 Sec63 SEC63 (S. cerevisiae5.7 5.7 
 103061_at Z49976 Gad1 Glutamic acid decarboxylase 1 4.9 2.3 
 103006_at AB012276 Atf5 Activating transcription factor 5 4.3 5.7 
 96869_at AW124839 Gabarap γ-aminobutyric acid receptor-associated protein 
 104669_at U73037 Irf7 IFN regulatory factor 7 3.5 2.1 
 102696_s_at A1747899 Pitpnb Phosphotidylinositol transfer protein, β 3.2 
 102737_at U35233 Edn1 Endothelin 1 3.2 2.6 
 103578_at AJ006972 Tom1 Target of myb1 homologue (chicken) 2.8 4.6 
 103957_at X57349 Trfr Transferring receptor 2.8 2.5 
 92777_at M32490 Cyr61 Cysteine rich protein 61 2.6 
 98104_at A1842889 Atp6f ATPase, H+ transporting, lysosomal (vacuolar proton pump) 2.6 2.3 
 101947_at AB028921 Nakap95-pending Neighbor of A-kinase anchoring protein 95 2.6 3.2 
 160119_at A1845538 Etv6 Ets variant gene 6 (TEL oncogene) 2.5 
 94918_at AI839392 C76919 Expressed sequence C76919 2.3 3.2 
 97859_at AA762325 Nkx6-2 NK6 transcription factor related, locus 2 (Drosophila) 2.3 2.5 
 96841_at AW046627  Serine threonine kinase pim3 2.3 2.3 
 104048_at AI848732 Cars Cysteinyl-tRNA synthetase 2.3 
 104598_at X61940 Ptpn16 Protein tyrosine phosphatase, nonreceptor type 16 2.3 2.5 
 102292_at U00937  Cluster Incl U00937:Mus musculus GADD45 protein (gadd45) gene 2.3 
 92603_at U13840 Atp6d ATPase, H+ transporting, lysosomal (vacuolar proton pump), 42 kDa 2.1 2.1 
 95057_at AI846938 Herpud1 Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.1 
 98048_at AF060490 Nssr Neural-salient serine/arginine-rich 2.1 3.2 
 101995_at U40930 Sqstm1 Sequestosome 1 2.1 3.5 
 102798_at U77630 Adm Adrenomedullin 2.1 3.5 
Down-regulated      
 96055_at X59520  Cluster Incl X59520:Cholecystokinin 2.1 
 96585_at AJ006691  Cluster Incl AJ006691:Mus musculus v2r gene 6.5 3.7 
 100030_at D44464 Upp Uridine phosphorylase 3.5 
 102389_s_at AI841303 Gap43 Growth associated protein 43 2.8 2.5 
 93550_at D88792 Csrp2 Cysteine-rich protein 2 2.6 
 161117_at AJ243963 Dkk2 Dickkopf2 2.6 12.1 
 95434_at AI851740 Arpc3 Actin related protein 2/3 complex, subunit 3 (21 kDa) 2.3 2.5 
 103556_at AI840158 AW260363 Expressed sequence AW260363 2.1 
 97934_at U73820 Galnt1 UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 2.1 2.3 
 160477_at AW046205 Ndufa4 NADH dehydrogenase (ubiquinone) 1 α subcomplex, 4 2.1 2.1 
 160655_at D85391 Cpd Carboxypeptidase D 2.1 2.3 
AffylDAccession no.SymbolNameNmt/NwtHwt/Nwt
Up-regulated by CREB      
 92830_s_at X14678 Zfp36 Zinc finger protein 36 11.3 9.8 
 101857_at AB006036 Srpk2 Serine/arginine-rich protein-specific kinase 2 6.1 
 160618_at AA760613 Lgals8 Lectin, galactose binding, soluble 8 
 99350_at C76102 Sec63 SEC63 (S. cerevisiae5.7 5.7 
 103061_at Z49976 Gad1 Glutamic acid decarboxylase 1 4.9 2.3 
 103006_at AB012276 Atf5 Activating transcription factor 5 4.3 5.7 
 96869_at AW124839 Gabarap γ-aminobutyric acid receptor-associated protein 
 104669_at U73037 Irf7 IFN regulatory factor 7 3.5 2.1 
 102696_s_at A1747899 Pitpnb Phosphotidylinositol transfer protein, β 3.2 
 102737_at U35233 Edn1 Endothelin 1 3.2 2.6 
 103578_at AJ006972 Tom1 Target of myb1 homologue (chicken) 2.8 4.6 
 103957_at X57349 Trfr Transferring receptor 2.8 2.5 
 92777_at M32490 Cyr61 Cysteine rich protein 61 2.6 
 98104_at A1842889 Atp6f ATPase, H+ transporting, lysosomal (vacuolar proton pump) 2.6 2.3 
 101947_at AB028921 Nakap95-pending Neighbor of A-kinase anchoring protein 95 2.6 3.2 
 160119_at A1845538 Etv6 Ets variant gene 6 (TEL oncogene) 2.5 
 94918_at AI839392 C76919 Expressed sequence C76919 2.3 3.2 
 97859_at AA762325 Nkx6-2 NK6 transcription factor related, locus 2 (Drosophila) 2.3 2.5 
 96841_at AW046627  Serine threonine kinase pim3 2.3 2.3 
 104048_at AI848732 Cars Cysteinyl-tRNA synthetase 2.3 
 104598_at X61940 Ptpn16 Protein tyrosine phosphatase, nonreceptor type 16 2.3 2.5 
 102292_at U00937  Cluster Incl U00937:Mus musculus GADD45 protein (gadd45) gene 2.3 
 92603_at U13840 Atp6d ATPase, H+ transporting, lysosomal (vacuolar proton pump), 42 kDa 2.1 2.1 
 95057_at AI846938 Herpud1 Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.1 
 98048_at AF060490 Nssr Neural-salient serine/arginine-rich 2.1 3.2 
 101995_at U40930 Sqstm1 Sequestosome 1 2.1 3.5 
 102798_at U77630 Adm Adrenomedullin 2.1 3.5 
Down-regulated      
 96055_at X59520  Cluster Incl X59520:Cholecystokinin 2.1 
 96585_at AJ006691  Cluster Incl AJ006691:Mus musculus v2r gene 6.5 3.7 
 100030_at D44464 Upp Uridine phosphorylase 3.5 
 102389_s_at AI841303 Gap43 Growth associated protein 43 2.8 2.5 
 93550_at D88792 Csrp2 Cysteine-rich protein 2 2.6 
 161117_at AJ243963 Dkk2 Dickkopf2 2.6 12.1 
 95434_at AI851740 Arpc3 Actin related protein 2/3 complex, subunit 3 (21 kDa) 2.3 2.5 
 103556_at AI840158 AW260363 Expressed sequence AW260363 2.1 
 97934_at U73820 Galnt1 UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 2.1 2.3 
 160477_at AW046205 Ndufa4 NADH dehydrogenase (ubiquinone) 1 α subcomplex, 4 2.1 2.1 
 160655_at D85391 Cpd Carboxypeptidase D 2.1 2.3 
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