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Table 1

Biological features associated with proliferation and apoptosis in colon cancers characterized for dysregulation in the APC/β-catenin/T-cell factor pathway

Total casesSurvivin expressionaApoptotic indexb median value (range)Proliferation indexc median value (range)
Median value (range)% of positive cases
β-Catenin negatived (microsatellite instability positive) 10 70 (0–100) 80% 0.6 (0–1.2) 72.5 (50–100) 
β-Catenin positive (microsatellite instability negative) 61 50 (0–90) 74% 0.4 (0–18.7) 85.0 (50–100) 
Total casesSurvivin expressionaApoptotic indexb median value (range)Proliferation indexc median value (range)
Median value (range)% of positive cases
β-Catenin negatived (microsatellite instability positive) 10 70 (0–100) 80% 0.6 (0–1.2) 72.5 (50–100) 
β-Catenin positive (microsatellite instability negative) 61 50 (0–90) 74% 0.4 (0–18.7) 85.0 (50–100) 
a

Percentage of tumor cells with cytoplasmic immunostaining. Cut-off value for positive cases = 25% of positive cells.

b

Percentage of tumor cells with cytoplasmic immunostaining for M30.

c

Percentage of tumor cells with nuclear immunostaining for MIB-1.

d

β-Catenin protein expression was evaluated on formalin-fixed, paraffin-embedded samples by immunohistochemistry (mouse monoclonal anti-β-catenin antibody; Transduction Laboratories, Lexington, KY) for the presence of nuclear, cytoplasmic, and membranous accumulation in both tumor and normal surrounding tissues.

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