Biological features associated with proliferation and apoptosis in colon cancers characterized for dysregulation in the APC/β-catenin/T-cell factor pathway
| . | Total cases . | Survivin expressiona . | . | Apoptotic indexb median value (range) . | Proliferation indexc median value (range) . | |
|---|---|---|---|---|---|---|
| . | . | Median value (range) . | % of positive cases . | . | . | |
| β-Catenin negatived (microsatellite instability positive) | 10 | 70 (0–100) | 80% | 0.6 (0–1.2) | 72.5 (50–100) | |
| β-Catenin positive (microsatellite instability negative) | 61 | 50 (0–90) | 74% | 0.4 (0–18.7) | 85.0 (50–100) | |
| . | Total cases . | Survivin expressiona . | . | Apoptotic indexb median value (range) . | Proliferation indexc median value (range) . | |
|---|---|---|---|---|---|---|
| . | . | Median value (range) . | % of positive cases . | . | . | |
| β-Catenin negatived (microsatellite instability positive) | 10 | 70 (0–100) | 80% | 0.6 (0–1.2) | 72.5 (50–100) | |
| β-Catenin positive (microsatellite instability negative) | 61 | 50 (0–90) | 74% | 0.4 (0–18.7) | 85.0 (50–100) | |
Percentage of tumor cells with cytoplasmic immunostaining. Cut-off value for positive cases = 25% of positive cells.
Percentage of tumor cells with cytoplasmic immunostaining for M30.
Percentage of tumor cells with nuclear immunostaining for MIB-1.
β-Catenin protein expression was evaluated on formalin-fixed, paraffin-embedded samples by immunohistochemistry (mouse monoclonal anti-β-catenin antibody; Transduction Laboratories, Lexington, KY) for the presence of nuclear, cytoplasmic, and membranous accumulation in both tumor and normal surrounding tissues.