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Table 2

EC50 of DCB-3500, DCB-3501, DCB-3502, and DCB-3503 on the growth inhibition of KB cells and its drug-resistant cells

A. EC50a
Cell lineDCB-3500 (nm)DCB-3501 (nm)DCB-3502 (nm)DCB-3503 (nm)
KB 12 ± 3 106 ± 84 234 ± 91 28 ± 4 
KB-MDRb 14 ± 5 143 ± 82 282 ± 138 26 ± 8 
KB-7D 12 ± 7 225 ± 206 527 ± 80 45 ± 10 
KB-7D-Rev 11 ± 6 70 ± 57 289 ± 188 25 ± 10 
KB-Hu-R 25 ± 7 70 ± 42 218 ± 167 36 ± 6 
KB-Hu-Rev 16 ± 4 45 ± 4 127 ± 95 28 ± 16 
KB-100 20 ± 10 103 ± 33 179 ± 63 38 ± 1 
KB-100-Rev 10 ± 3 118 ± 31 247 ± 122 41 ± 9 
A. EC50a
Cell lineDCB-3500 (nm)DCB-3501 (nm)DCB-3502 (nm)DCB-3503 (nm)
KB 12 ± 3 106 ± 84 234 ± 91 28 ± 4 
KB-MDRb 14 ± 5 143 ± 82 282 ± 138 26 ± 8 
KB-7D 12 ± 7 225 ± 206 527 ± 80 45 ± 10 
KB-7D-Rev 11 ± 6 70 ± 57 289 ± 188 25 ± 10 
KB-Hu-R 25 ± 7 70 ± 42 218 ± 167 36 ± 6 
KB-Hu-Rev 16 ± 4 45 ± 4 127 ± 95 28 ± 16 
KB-100 20 ± 10 103 ± 33 179 ± 63 38 ± 1 
KB-100-Rev 10 ± 3 118 ± 31 247 ± 122 41 ± 9 
B. Description of resistant cell lines
Cell lineBiochemical changesResistant toReference
KB-MDR gp 170 ↑ VP-16, taxol, Adriamycin, vincristine  24  
KB-7D Topo II ↓, MRP ↑ VP-16, vincristine, Adriamycin 25,26 
KB-7D-Rev Topo II ↓ VP-16, Adriamycin 25,26 
KB-HU-R RR ↑, dCK ↓ Hydroxyurea, araC, gemcitabine  27  
KB-HU-Rev dCK ↓ araC, gemcitabine  27  
KB-100 Topo I ↓, XRCC 1 ↑ CPT, topotecan, SN-38 28,29 
KB-100-Rev Topo I ↓ CPT, topotecan, SN-38  28  
B. Description of resistant cell lines
Cell lineBiochemical changesResistant toReference
KB-MDR gp 170 ↑ VP-16, taxol, Adriamycin, vincristine  24  
KB-7D Topo II ↓, MRP ↑ VP-16, vincristine, Adriamycin 25,26 
KB-7D-Rev Topo II ↓ VP-16, Adriamycin 25,26 
KB-HU-R RR ↑, dCK ↓ Hydroxyurea, araC, gemcitabine  27  
KB-HU-Rev dCK ↓ araC, gemcitabine  27  
KB-100 Topo I ↓, XRCC 1 ↑ CPT, topotecan, SN-38 28,29 
KB-100-Rev Topo I ↓ CPT, topotecan, SN-38  28  
a

Values are means ± SD of three experiments, with each data point done in triplicate.

b

MDR, multidrug resistance; MRP, multidrug resistance protein; VP-16, etoposide; HU, hydroxyurea; RR, ribonucleotide reductase; dCK, deoxycytidine kinase; Topo II, topoisomerase II; Topo I, topoisomerase I; XRCC1, X-ray repair cross-complementing gene I protein; araC, arabinoside cytosine; CPT, camptothecin; SN-38, 7-ethyl-10-hydroxycamptothecin.

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