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Table 1

Growth inhibition and loss of clonogenicity of KB (human nasopharyngeal carcinoma) and HepG2 (hepatocyte carcinoma) cellsa

A. EC50b (growth inhibition)
Cell lineDCB-3500 (nm)DCB-3501 (nm)DCB-3502 (nm)DCB-3503 (nm)
KB 12 ± 3 106 ± 84 234 ± 91 28 ± 4 
HepG2 11 ± 4 110 ± 45 264 ± 115 35 ± 5 
A. EC50b (growth inhibition)
Cell lineDCB-3500 (nm)DCB-3501 (nm)DCB-3502 (nm)DCB-3503 (nm)
KB 12 ± 3 106 ± 84 234 ± 91 28 ± 4 
HepG2 11 ± 4 110 ± 45 264 ± 115 35 ± 5 
B. CC50c (colony-forming ability)
Cell lineDCB-3500 (μm)DCB-3501 (μm)DCB-3502 (μm)DCB-3503 (μm)
KB 0.83 ± 0.31 3.07 ± 1.17 6.29 ± 3.74 1.55 ± 0.47 
HepG2 0.04 ± 0.006 0.21 ± 0.13 0.45 ± 0.13 0.17 ± 0.08 
B. CC50c (colony-forming ability)
Cell lineDCB-3500 (μm)DCB-3501 (μm)DCB-3502 (μm)DCB-3503 (μm)
KB 0.83 ± 0.31 3.07 ± 1.17 6.29 ± 3.74 1.55 ± 0.47 
HepG2 0.04 ± 0.006 0.21 ± 0.13 0.45 ± 0.13 0.17 ± 0.08 
a

Values are means ± SD of three experiments, with each data point done in triplicate.

b

Statistical analyses (one-way ANOVA and two-way ANOVA) showed that there was a significant difference between drugs (P < 0.05) but no significant difference between cell lines (P = 0.14).

c

Statistical analyses (one-way ANOVA and two-way ANOVA) showed that there was a significant difference between drugs (P < 0.05), and there was an extremely significant difference between cell lines (P < 0.0001).

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