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Table 3

Principal toxic effects during bortezomib treatment in androgen-independent prostate cancer (17) 

Any grade toxicity All cycles Patients (%)Grade 3 toxicitya Cycle 1 Patients (%)
Parameter n = 53 n = 53 
Likely related to bortezomib   
Diarrhea 28 (53) 3 (6) 
Fatigue 27 (51) 1 (2) 
Constipation 25 (47) 1 (2) 
Nausea 22 (42) 
Vomiting 18 (34) 
Weakness 14 (26) 2 (4) 
Abdominal pain 13 (25) 
Appetite decreased 12 (23) 
Hypotension 10 (19) 3 (6) 
Dizziness 8 (15) 
Abdominal distension 7 (13) 
Hypertension 6 (11) 1 (2) 
Flatulence 6 (11) 
Neuropathy 4 (8) 1 (2) 
Likely unrelated to bortezomib   
Back pain 15 (28) 
Catheter related complication 15 (28) 
Bone pain 13 (25) 
Pyrexia 13 (25) 
Arthralgia 11 (21) 
Headache 11 (21) 
Urinary tract infection 11 (21) 
Dyspnea 9 (17) 
Anemia 8 (15) 
Cardiac murmur 8 (15) 
Hematuria 8 (15) 
Hypomagnesemia 7 (13) 
Edema lower limb 7 (13) 1 (2) (due to DVT) 
Pain in limb 7 (13) 
Nocturia 6 (11)  
Rigors 6 (11)  
Urinary frequency 6 (11)  
Any grade toxicity All cycles Patients (%)Grade 3 toxicitya Cycle 1 Patients (%)
Parameter n = 53 n = 53 
Likely related to bortezomib   
Diarrhea 28 (53) 3 (6) 
Fatigue 27 (51) 1 (2) 
Constipation 25 (47) 1 (2) 
Nausea 22 (42) 
Vomiting 18 (34) 
Weakness 14 (26) 2 (4) 
Abdominal pain 13 (25) 
Appetite decreased 12 (23) 
Hypotension 10 (19) 3 (6) 
Dizziness 8 (15) 
Abdominal distension 7 (13) 
Hypertension 6 (11) 1 (2) 
Flatulence 6 (11) 
Neuropathy 4 (8) 1 (2) 
Likely unrelated to bortezomib   
Back pain 15 (28) 
Catheter related complication 15 (28) 
Bone pain 13 (25) 
Pyrexia 13 (25) 
Arthralgia 11 (21) 
Headache 11 (21) 
Urinary tract infection 11 (21) 
Dyspnea 9 (17) 
Anemia 8 (15) 
Cardiac murmur 8 (15) 
Hematuria 8 (15) 
Hypomagnesemia 7 (13) 
Edema lower limb 7 (13) 1 (2) (due to DVT) 
Pain in limb 7 (13) 
Nocturia 6 (11)  
Rigors 6 (11)  
Urinary frequency 6 (11)  
a

No grade 4 toxicity was observed during the study.

DVT, Deep Vein Thrombosis.

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