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Table 1

Data for intestinal polyps in Apc¹³⁰⁹ mice treated with PPAR ligands^a

Polyp location	Pioglitazone (ppm)					Bezafibrate (ppm)
Polyp location		0 (10)^b	100 (8)	200 (9)	0 (6)	100 (6)	200 (8)
Proximal small intestine	9.5 ± 1.1^c,^d	5.8 ± 1.6	5.5 ± 1.1^e	10.3 ± 1.1	7.7 ± 1.2	7.5 ± 1.5
Middle small intestine	15.7 ± 1.1	11.4 ± 2.1	9.6 ± 1.8^f	15.0 ± 1.7	13.3 ± 1.2	11.3 ± 1.3
Distal small intestine	10.9 ± 1.2	7.0 ± 1.3^e	9.0 ± 1.8	11.7 ± 0.5	11.2 ± 0.7	9.0 ± 1.1
Colon	0.6 ± 0.2	0.5 ± 0.3	0.4 ± 0.2	0.7 ± 0.3	0.5 ± 0.3	0.5 ± 0.3
Total	36.7 ± 2.7	24.6 ± 4.4^e	24.5 ± 4.2^e	37.7 ± 2.9	32.7 ± 1.7	28.3 ± 2.7^e

Polyp location	Pioglitazone (ppm)					Bezafibrate (ppm)
Polyp location		0 (10)^b	100 (8)	200 (9)	0 (6)	100 (6)	200 (8)
Proximal small intestine	9.5 ± 1.1^c,^d	5.8 ± 1.6	5.5 ± 1.1^e	10.3 ± 1.1	7.7 ± 1.2	7.5 ± 1.5
Middle small intestine	15.7 ± 1.1	11.4 ± 2.1	9.6 ± 1.8^f	15.0 ± 1.7	13.3 ± 1.2	11.3 ± 1.3
Distal small intestine	10.9 ± 1.2	7.0 ± 1.3^e	9.0 ± 1.8	11.7 ± 0.5	11.2 ± 0.7	9.0 ± 1.1
Colon	0.6 ± 0.2	0.5 ± 0.3	0.4 ± 0.2	0.7 ± 0.3	0.5 ± 0.3	0.5 ± 0.3
Total	36.7 ± 2.7	24.6 ± 4.4^e	24.5 ± 4.2^e	37.7 ± 2.9	32.7 ± 1.7	28.3 ± 2.7^e

Mice were fed the basal diet or a diet containing 100 or 200 ppm of PPAR ligand for 6 weeks.

Numbers in parenthesis are the numbers of animals examined.

Number of polyps per mouse.

Data are means ± SE.

Versus the basal diet group: P < 0.05.

Versus the basal diet group: P < 0.01.