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Table 1

Demographic characteristics and breast cancer risk factors by duration of NSAID exposure in the WHI Observational Study

Characteristic or breast cancer risk factoraDuration of NSAID exposure
0–11 mo1 to <5 yr>5 yrTotal
n%n%n%n%
Age at screening, yr         
50–59 18,999 72.0 3,207 12.2 4,176 15.8 26,382 32.7 
 60–69b 23,586 66.3 5,607 15.8 6,401 18.0 35,594 44.1 
 70–79b 11,517 61.4 3,433 18.3 3,815 20.3 18,765 23.2 
Race/ethnicity         
White 43,723 65.1 10,569 15.7 12,884 19.2 67,176 83.2 
 Blackb 4,834 74.3 893 13.7 775 11.9 6,502 8.1 
 Hispanicb 2,404 76.5 390 12.4 347 11.0 3,141 3.9 
 Native American 246 69.7 45 12.7 62 17.6 353 0.4 
 Asian/Pacific Islanderb 2,088 85.8 195 8.0 151 6.2 2,434 3.0 
 Unknownb 807 71.1 155 13.7 173 15.2 1,135 1.4 
Education         
≤HS diploma/GED 11,173 65.2 2,817 16.4 3,143 18.3 17,133 21.4 
 Some school after HS 19,159 65.7 4,568 15.7 5,418 18.6 29,145 36.4 
 College degree or higherb 23,321 69.0 4,763 14.1 5,725 16.9 33,809 42.2 
BMI (kg/m2        
<27 31,622 69.2 6,366 13.9 7,710 16.9 45,698 57.3 
 ≥27b 21,825 64.0 5,756 16.9 6,520 19.1 34,101 42.7 
HRT use (ever)         
No 22,340 70.3 4,514 14.2 4,915 15.5 31,769 39.3 
 Yesb 31,762 64.9 7,733 15.8 9,477 19.4 48,972 60.7 
Family history of breast cancer         
No 41,813 67.4 9,347 15.1 10,890 17.6 62,050 81.2 
 Yes 9,407 65.7 2,203 15.4 2,710 18.9 14,320 18.8 
Parous under age 30         
No 11,204 69.3 2,265 14.0 2,688 16.6 16,157 22.3 
 Yesb 37,228 66.0 8,759 15.5 10,406 18.5 56,393 77.7 
Episodes/wk of exercise (≥20 min)         
<2 27,105 65.8 6,420 15.6 7,649 18.6 41,174 51.6 
 ≥2b 26,266 68.1 5,706 14.8 6,623 17.2 38,595 48.4 
Total 54,102 67.0 12,247 15.2 14,292 17.8 80,741 100.0 
Characteristic or breast cancer risk factoraDuration of NSAID exposure
0–11 mo1 to <5 yr>5 yrTotal
n%n%n%n%
Age at screening, yr         
50–59 18,999 72.0 3,207 12.2 4,176 15.8 26,382 32.7 
 60–69b 23,586 66.3 5,607 15.8 6,401 18.0 35,594 44.1 
 70–79b 11,517 61.4 3,433 18.3 3,815 20.3 18,765 23.2 
Race/ethnicity         
White 43,723 65.1 10,569 15.7 12,884 19.2 67,176 83.2 
 Blackb 4,834 74.3 893 13.7 775 11.9 6,502 8.1 
 Hispanicb 2,404 76.5 390 12.4 347 11.0 3,141 3.9 
 Native American 246 69.7 45 12.7 62 17.6 353 0.4 
 Asian/Pacific Islanderb 2,088 85.8 195 8.0 151 6.2 2,434 3.0 
 Unknownb 807 71.1 155 13.7 173 15.2 1,135 1.4 
Education         
≤HS diploma/GED 11,173 65.2 2,817 16.4 3,143 18.3 17,133 21.4 
 Some school after HS 19,159 65.7 4,568 15.7 5,418 18.6 29,145 36.4 
 College degree or higherb 23,321 69.0 4,763 14.1 5,725 16.9 33,809 42.2 
BMI (kg/m2        
<27 31,622 69.2 6,366 13.9 7,710 16.9 45,698 57.3 
 ≥27b 21,825 64.0 5,756 16.9 6,520 19.1 34,101 42.7 
HRT use (ever)         
No 22,340 70.3 4,514 14.2 4,915 15.5 31,769 39.3 
 Yesb 31,762 64.9 7,733 15.8 9,477 19.4 48,972 60.7 
Family history of breast cancer         
No 41,813 67.4 9,347 15.1 10,890 17.6 62,050 81.2 
 Yes 9,407 65.7 2,203 15.4 2,710 18.9 14,320 18.8 
Parous under age 30         
No 11,204 69.3 2,265 14.0 2,688 16.6 16,157 22.3 
 Yesb 37,228 66.0 8,759 15.5 10,406 18.5 56,393 77.7 
Episodes/wk of exercise (≥20 min)         
<2 27,105 65.8 6,420 15.6 7,649 18.6 41,174 51.6 
 ≥2b 26,266 68.1 5,706 14.8 6,623 17.2 38,595 48.4 
Total 54,102 67.0 12,247 15.2 14,292 17.8 80,741 100.0 
a

NSAID exposure includes aspirin, ibuprofen, prescription NSAIDs, and the related analgesic, acetaminophen. Subgroup comparisons of the distribution of duration of NSAID exposure were assessed using χ2 tests. Each subgroup is compared with the underlined reference subgroup.

b

Subgroup comparisons with P < 0.0001.

c

HS, high school; GED, General Equivalency Diploma.

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